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Biomedical subjects

Y J Cho

Publications and source records attributed to Y J Cho.

79 records · Page 5Linked to original sources
PubMed1983

Effects of dietary trans-fat on biliary and fecal steroid excretion and serum lipoproteins in rats.

Rats were fed cholesterol-free or cholesterol-enriched diets containing olive oil or partially hydrogenated corn oil at the 10% level for ca. 30 days (c-18:1, 77.0% in the former diet and c-18:1,24.7% and t-18:1,42.5% in the latter). The linoleic acid content of these fat diets was made equivalent (1.7 energy %). After feeding cholesterol-free diets, trans fat compared to cis fat showed (a) no untoward effects on growth parameters, (b) a reduction of serum cholesterol levels without influencing concentrations of serum apolipoproteins A-1, B and E, (c) no effects on the bile flow and the concentration of biliary cholesterol and bile acids, (d) an increasing trend of fecal excretion of neutral and acidic steroids, both in terms of mg/day and mg/g feces, and (e) rather equivocal change in the composition of fecal, but not biliary steroids. Similar response patterns were also observed when cholesterol-enriched diets were fed except for a decrease in serum apo B and an ineffectiveness to increase fecal acidic steroids. Together with the results obtained from experiments simultaneously performed with safflower oil and completely hydrogenated corn oil, it seems that the steroid metabolism can be specifically modified by the geometry of dietary fats.

Animals↗
PubMed1978

IgE antibody production to exoenzymes and common antigen (OEP) of Pseudomonas aeruginosa in mice.

IgE antibody production to exoenzymes and common antigen (OEP) of P. aeruginosa was studied in mice that were injected with the antigens incorporated into water-in-oil-in-water (w/o/w) emulsion or Al(OH)3 gel. OEP and protease toxoid (PT) elicited IgE antibody response but elastase toxoid (ET) did not. Capacity of the OEP to produce IgE antibody was reduced remarkably by it's protease treatment, which suggested that the capacity lies in the protein portion of OEP. The w/o/w emulsion was less effective than Al(OH)3 gel in adjuvanticity to elicit IgE antibody response, but the emulsion enhanced the IgM and/or IgG antibody response to PT and maintained a constant level for a long period. These findings may suggest that IgE antibody response to some components of P. aeruginosa could be induced in man. High serum level of IgE was observed in some cases of cystic fibrosis caused by P. aeruginosa infection, although the IgE antibody activity has not yet been determined.

Animals↗
PubMed1977

Citation characteristics of periodical literature in veterinary science.

The usage of periodical literature in veterinary science was measured by means of citation analysis. Eighty-two percent of the citations in the source of this study, Advances in Veterinary Science and Comparative Medicine (1970-1974), were from periodicals, and 70 of the 743 periodical titles cited (9.4%) contributed 66% of the total periodical citations. Periodical literature cited in the source of the study appeared to have a half-life of 6.1 years, and to double its size approximately every 20 years. The aging patterns of the periodical literature seemed to vary with the publishing age of the periodical, i.e., the literature in the periodicals which have been in publication for more than 40 years showed a more gradual aging pattern than did that in the newer periodicals.

Periodicals as Topic↗
PubMedDate not supplied

Extraction and simultaneous elution and derivatization of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol using Toxi-Lab SPEC prior to GC/MS analysis of urine.

A new sample preparation procedure is described for the extraction and simultaneous elution and derivation of urine for analysis of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THC-COOH) by gas chromatography/ion trap mass spectrometry (GC/MS). Urine samples are extracted for THC-COOH and d6-THC-COOH internal standard onto a hydrophobic membrane. Extracts are simultaneously eluted and derivatized with MSTFA while on the membrane to produce the corresponding trimethylsilane derivative. Using results of blank urine, the limits of detection and quantitation were 1.1 and 2.5 ng/mL, respectively. The linearity of the assay was 250 ng/mL. The within-run and day-to-day precision ranged 3-5%. Compared with a solid-phase column extraction procedure, the overall time for sample preparation was decreased from 3 h down to 1. The SPEC extraction procedure with trimethyl derivatization produces a cleaner total ion chromatogram than the solid-phase column extraction system (minicolumn) and does not require the use of any organic solvents.

Dronabinol↗