[Magnetic resonance imaging of iron storage diseases].
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Biomedical subjects
Publications and source records attributed to Y Itai.
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Computed tomography (CT) was performed after 65 transcatheter arterial embolizations (TAE) in 50 patients with hepatocellular carcinoma. Nonenhanced high-density areas were seen in the tumors within 3 days in 17/25 cases (though they soon disappeared) and low-density areas within 2 weeks in 62/65. Gas bubbles were seen in these areas within 2 weeks in 60% of embolizations. Within 3 to 6 months after the first TAE, enhanced lesions developed around or inside the low-density areas in 15/22 patients. Complications appearing within 2 weeks included non-enhanced low-density areas in the liver and spleen, gallbladder thickening, swelling of the head of the pancreas, contrast retention in the kidneys and gallbladder, ascites, and pleural effusion.
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Fifteen patients with primary intrahepatic biliary malignancy (cholangiocarcinoma in 13, biliary cystadenocarcinoma in two) were examined by computed tomography (CT). The CT features were classified into three types: (A) a well-defined round cystic mass with internal papillary projections, (B) a localized intrahepatic biliary dilatation without a definite mass lesion, and (C) miscellaneous low-density masses. Intrahepatic biliary dilatation was noted in all cases of Types A and B and half of those of Type C; dilatation of extrahepatic bile ducts occurred in 4/4, 1/3, and 0/8, respectively. CT patterns, such as a well-defined round cystic mass with papillary projections or dilatation of intra- and extrahepatic ducts, give important clues leading to a correct diagnosis of primary intrahepatic biliary malignancy.
Accuracy and limitations of computed tomography (CT) and sonography in the detection and diagnosis of cavernous hemangioma of the liver were analyzed in 39 cases. In 35 of 38 lesions examined by CT before and after bolus contrast enhancement, findings were dense contrast enhancement spreading in all directions on subsequent scans and/or density (other than capsule or septa) higher than normal hepatic parenchyma after 2 min. Lesions smaller than 1 cm were not detected. Misregistration in sequential scans prevented diagnosis of three of nine lesions smaller than 2 cm. Sonography revealed various patterns of mass, but in the smaller lesions, an extremely hyperechoic pattern was dominant. The contributions of CT and sonography depend on the size of the lesions.
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Computed tomographic (CT) and ultrasonographic (US) images of 17 patients with septate cystic lesions in the upper abdomen were reviewed. US was superior to CT in detecting septation and its presence suggested that the 'cyst' was neoplastic in nine. CT plays a complementary role in differentiating cystic lesions.
Pancreatic cysts were diagnosed on computed tomography (CT) in 6 (8%) of 73 histologically proven pancreatic carcinomas. In three of a total of seven cases studied, the initial CT diagnosis was pancreatitis. The CT features of cysts secondary to pancreatic carcinoma were identical to those of pseudocysts in pancreatitis. All cases had masses of varying sizes suggestive of carcinoma or pancreatitis. Even in retrospect, two cases were difficult to differentiate from pancreatitis with pseudocysts. Our results indicate that whenever pancreatic cysts are encountered in patients of cancer age without a history of pancreatitis, further examinations including percutaneous aspiration biopsies should be performed to exclude malignancy.
The plan radiographs and computed tomography (CT) scans of 12 children with abdominal neuroblastoma were reviewed to evaluate the incidence and shape of calcification in the tumor. Calcifications were detected in 7 cases by plain radiographs and in 10 by CT. Small dotted and thin ring calcifications were better shown by CT. Ring calcification does not appear to be as rare as has been reported. It is emphasized that all ring calcifications in the vicinity of adrenal glands are not benign.
Thirteen patients with resectable pancreatic carcinoma were examined by computed tomography (CT). Nine had a mass, 2 had dilatation of the main pancreatic duct, 1 appeared to have ductal dilatation, and 1 had no sign of abnormality. Resectable carcinoma was diagnosed retrospectively in 8 cases, based on the following criteria: a mass with a distinct contour, frequently containing a tiny or irregular low-density area and accompanied by dilatation of the caudal portion of the main pancreatic duct without involvement of the large vessels, liver, or lymph nodes. Including unresectable cancer, chronic pancreatitis, and obstructive jaundice from causes other than cancer, the false-positive rate was less than 6%. However, a small cancer without change in pancreatic contour is difficult to detect with CT.
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Ten cases of cystadenoma or cystadenocarcinoma of the pancreas were examined by computed tomography (CT). All but one showed characteristic findings consisting of both cystic and solid components. Innumerable small cysts producing a honeycomb appearance were noticed in serous cystadenomas. A well-defined multilocular cystic mass containing thin, straight, and/or curvilinear septa or a unilocular cystic tumor with a papillary projection and locally thickened wall was present in mucinous cystadenomas. The CT findings in cystadenocarcinomas varied depending on the relative size of the cystic and solid portions and the grade of malignancy. CT was useful in detecting and diagnosing cystic neoplasms of the pancreas and differentiating benign serous cystadenomas from potentially malignant cystadenomas in typical cases. However, aspiration biopsy is recommended when findings are equivocal.
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