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Biomedical subjects

Y Isobe

Publications and source records attributed to Y Isobe.

At least 199 records · Page 11Linked to original sources
PubMed1976

Inflammatory myopathy, IgA deficiency, and intestinal malabsorption.

Two IgA-deficient children with inflammatory myopathy and intestinal malabsorption were evaluated. The myopathy was characterized by weakness of facial and proximal limb muscles, increased serum concentrations of lactic dehydrogenase and creatine phosphokinase, and histologic evidence of inflammation and degeneration of muscle fibers. Features of the intestinal abnormality were blunted villi, interstitial inflammation, and reduction in IgA-containing plasma cells and IgA content of epithelial cells. The myopathy and malabsorption improved with corticosteroid treatment. Circulating antibodies to striated muscle could not be demonstrated in either patient, but one had antibodies to milk and chicken serum proteins. We speculate that IgA deficiency may predispose to the development of inflammatory myopathy.

Autoantibodies↗
PubMed1976

Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa.

To define mechanisms involved in the transport of immunoglobulins into intestinal fluids, we localized IgM, IgA, IgG, and secretory component (SC) in human intestinal mucosa by the peroxidase-labeled antibody technique. At the light microscopic level, immunocytes containing IgA, IgM, or IgG were found in the lamina propria. IgA, IgM, and SC were prominent in the epithelium of gland crypts; IgG was limited to a few cells at tips of villi. At the electron-microscopic level, SC was localized to perinuclear spaces, endoplasmic reticulum, saccules associated with Golgi complexes, cytoplasmic vesicles, and lateral and basal plasma membranes of columnar epithelial cells. IgA and IgM, but not IgG, also were localized to plasma membranes and cytoplasmic vesicles of these cells. Neither the immunoglobulins nor SC was found within other types of epithelial cells (Paneth, goblet, endocrine). The findings provide evidence that (1) the site of SC synthesis in intestinal epithelium is secretory columnar cells, principally those in gland crypts; (2) the polymeric immunoglobulins IgM and IgA are translocated through such SC-containing cells by a process that involves formation of cytoplasmic vesicles; (3) IgM and IgA could combine with SC during transcellular transport (likely sites are lateral or basal plasma membranes or supranuclear cytoplasm); (4) the monomeric immunoglobulin IgG does not share the transepithelial cell route involved in IgM and IgA transport.

Biological Transport↗
PubMed1975

Prediction of survival time of rats in severe heat.

The response pattern of the rectal temperature of unanesthetized rats exposed to an acute heat in a room of 42.5 degrees C, rh 40% was analyzed in relation to survival time (S), equilibrium rectal temperature (Te), rise in Te from the initial temperature (Delta Te), and the slope of the changes in rectal temperature during the equilibrium period (Gt). A very wide fluctuation of the survival time (from 46.8 to 250.0 min) was observed between individual rats. For prediction of the survival time, following formula was obtained: log(S) = K1 - K2 times log (Te) - K3 times log (Delta Te) + k4 times 10- minus Gt. K1-4 are constants which differ according to sex. The predicted survival time showed highly constant results in individual rats when measured by repeated exposures. The predicted time coincided well with the survival time actually measured, the difference between the two (measured minus predicted) being 2.2 plus or minus 21.7 min (mean plus or minus SD) IN 77 RATS. There was also a significant correlation between the survival time predicted for acute heat exposure and the actual survival time of individual rats when they were exposed to a chronic heat by daily elevation of the rearing room temperature by 1.0 degrees C.

Adaptation, Physiological↗