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Biomedical subjects

Y Ishigami

Publications and source records attributed to Y Ishigami.

22 records · Page 2Linked to original sources
PubMed1989

[Development and clinical application of ICG clearance meter].

We have developed a finger-piece method that can indicates an accurate concentration of ICG based on the two wavelength spectrophotometry. Seventy-eight subjects were evaluated by this new method. The ICG clearance curve obtained from ICG clearance meter showed a rapid increase 20 or 40 seconds after the bolus injection. The curve decreased gradually, and increased again at 60 or 70 seconds. Plasma disappearance rate (PDR) by this method (XK ICG) was calculated by the at least square method from 600 data obtained from 5 to 15 minutes after the injection. There was a significant correlation between conventional PDR (KICG) and new method (XK ICG) also. We assume that this method have a possibility to discover new aspect of pharmacokinetics of ICG.

Adolescent↗
PubMed1987

Structure and function of red cell cytoskeleton.

Red cell shape changed reversibly depending on the ATP level, but the volume did not change. The surface area of both lipid bilayer and cytoskeleton network changed depending on the ATP level. Mild trypsin treatment of ghosts dissipated only ankyrin band and abolished the shape-and viscosity-change induced by CPZ and ATP+warming. Triton shells losing permeability barrier shrunk on addition of small concentrations of Ca2+ and swelled again on further addition of MgATP. The shells dissociated in 0.1mM MgATP and reassociated in 0.15M KC1. The nucleotide specificity was high. From diameters of cells, ghosts and shells at different pH and others, we propose that the erythrocyte shape is primarily decided by the cytoskeleton, the role of the lipid bilayer is complementary and thirdly the shape is modified by the relative volume of the cytoplasma.

Cytoplasm↗