Severe renal impairment and massive proteinuria are rare in pheochromocytoma. We report the case of a patient with pheochromocytoma who repeatedly developed episodes of acute renal deterioration and transient, massive proteinuria. Each episodes followed hypotensive periods, two of which seemed to be induced by administration of metoclopramide. The pathogenetic mechanisms of acute renal deterioration and proteinuria are discussed.

Acute Kidney Injury↗

PubMed1985

[A case of acute respiratory failure due to nitrous fumes and hydrogen fluoride].

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Acute Disease↗

PubMed1984

Tripeptides acting on opioid receptors in rat colon.

The tripeptides SD-34 and SD-25 induced atropine-, guanethidine-, antihistaminics-resistant but naloxone-sensitive contractions of isolated rat distal colon. They appeared to act on an opioid receptor, probably of the mu subtype, distinct from those for methionine enkephalin and morphine, because the pA2 values of naloxone for the peptides were similar to those for mu-agonists but different from those for methionine enkephalin and morphine, and because the peptides caused contractions of colon that had been desensitized to morphine. Mr 2266, a supposed kappa-antagonist, inhibited the actions of the peptides, ethylketocyclazocine and dynorphin at concentrations much lower than those inhibiting the actions of methionine enkephalin and morphine. Thus these peptides seem to act on the mu- and/or kappa-receptors. The actions of the tripeptides were inhibited by methysergide and methylergometrine, but not by the 5-HT2 antagonist ketanserin, and were not affected by 5-HT or substance P autodesensitization . Thus their actions do not seem to involve 5-HT, histamine, ACh or substance P. It seems likely that the tripeptides, through opioid receptors, directly activate the muscle, or remove some inhibitory modulation of myogenic activity, thus causing contractions.

Animals↗

PubMed1984

Effects of long-term prazosin therapy on lipoprotein metabolism in hypertensive patients.

Prazosin administration caused a significant and continuous antihypertensive effect when given as a single agent for 12 months. The daily dose was stabilized after three months at 6.0 mg per day. After 12 months of prazosin treatment, high-density lipoprotein cholesterol increased by 17 percent (p less than 0.005) and the cholesterol ratio increased by 19 percent (p less than 0.05), but total cholesterol was not significantly changed. There were no statistically significant changes in triglycerides, plasma renin activity, and plasma aldosterone concentration following treatment when compared with baseline levels. Prazosin monotherapy is concluded to have favorable effects on serum lipids and can be considered suitable for long-term antihypertensive therapy.

Adult↗

PubMed1984

Complement sensitivity of erythroid and myeloid precursors in paroxysmal in nocturnal hemoglobinuria.

To test the hypothesis that paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder, the growth of BFU-e and CFU-gm and the complement sensitivity of cultured cells from BFU-e and CFU-gm colonies, as well as of unipotential progenitor cells (CFU-gm and BFU-e), were examined in five PNH patients. BFU-e growth was reduced in the three patients examined, and poor CFU-gm growth was noted in three of the five patients. Compared to normals, BFU-e and CFU-gm colonies in all patients demonstrated an increased susceptibility to the lytic action of complement when the release of 59Fe and myeloperoxidase was measured as specific markers for monitoring membrane damage. Compared to the growth of normal bone marrow cells, CFU-gm growth was significantly inhibited by pretreatment of bone marrow mononuclear cells with monoclonal OKIal antibody and complement. These findings support the proposition that a membrane defect predisposing blood cells to complement-mediated lysis may occur at the level of unipotential progenitor cells.

Colony-Forming Units Assay↗

PubMed1984

Papaverine enhances the effect of adenosine in guinea-pig atria.

Papaverine, while enhancing the force of contraction of guinea-pig atria, remarkably and dose-dependently enhanced the negative inotropic response of the atria to adenosine. It also enhanced the actions of ATP and other adenine nucleotides, but not those of 2-chloroadenosine and ACh. At similar concentrations, papaverine inhibited the uptake of adenosine by the atrial tissue during incubation with adenosine. Adenosine in the medium was degraded to inactive inosine during incubation with the atrial tissue, and papaverine reduced its degradation. The enhancing effect of papaverine on the action of adenosine on guinea-pig atria was like those of dipyridamole, 6-(2-hydroxy-5-nitrobenzyl)thioguanosine and cinepazide. The effect seemed to be due mainly to inhibition of adenosine uptake into the tissue. Inhibition of adenosine degradation may also have contributed to the action of papaverine, but this action was probably much less important than inhibition of adenosine uptake.

Adenine Nucleotides↗

PubMed1984

Immunohistochemical localization of neurofilament protein in neuronal degenerations.

The immunohistochemical localization of human neurofilament proteins was studied in a variety of neuronal changes by the peroxidase-antiperoxidase method using antisera raised against each of the subunit proteins of human neurofilament. Torpedoes of the cerebellum, axonal spheroids of amyotrophic lateral sclerosis as well as of infantile neuroaxonal dystrophy, and neurofibrillary changes in a case of Pick's disease were consistently immunostained. Occasionally, a positive immunoreactivity was also observed in Lewy bodies, in neurofibrillary tangles of progressive supranuclear palsy, and in neuritic processes of senile plaques. Neurofibrillary tangles of Alzheimer type and Pick's bodies, however, did not react with the antisera. These data indicate that the human neurofilament does not share major antigenic determinants of its subunit protein with either Alzheimer's neurofibrillary tangles or Pick's bodies.

Alzheimer Disease↗

PubMed1984

Pancreatic arteriovenous malformation presenting as interesting findings on endoscopic retrograde pancreatography.

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Arteriovenous Malformations↗

PubMed1984

Relaxant effects of mercury and mercury uptake in the smooth muscle of guinea-pig taenia coli.

Hg2+ (0.005-0.5 mM) induced a concentration-dependent reduction on high-K+-induced contraction of taenia coli. The K+-induced increase in 45Ca uptake was significantly reduced in the presence of Hg2+ (0.05-0.5 mM). The contractions of the glycerinated taenia coli were inhibited by an increase in Hg2+ concentration. Mercury uptake increased along the duration of Hg2+ incubation. When muscles were rinsed with a medium containing 5 mM EDTA after 0.5 mM Hg2+ treatment for 90 min about 30% of the original level of tissue mercury was retained. Possible mechanism for the tension inhibitory action of Hg2+ include: (1) that Hg2+ bound to cell membrane initially interferes with the permeability of Ca2+ and that (2) the cellular mercury fraction that is not eliminated by EDTA subsequently correlates with the tension inhibitory action.

Animals↗

PubMed1984

Cooling-induced contraction in ileal longitudinal smooth muscle of guinea-pig.

The ileal longitudinal smooth muscle developed a transient contraction on cooling from 37 degrees C to 1 degree C in normal Ca2+ (2.5 mM) medium. The transient contraction was not inhibited by pretreatment with the Ca2+ antagonist, D-600 (1 X 10(-6)M). The contractions were sustained by cooling to 1 degree C in the presence of added Ca2+ greater than 10 mM. After the pretreatment with D-600, when the muscle incubated in normal medium with added 20 mM Ca2+ had been cooled to 1 degree C, a phasic response was only seen. However, D-600 did not inhibit the sustained contraction at 1 degree C after incubation in the presence of added 20 mM Ca2+. It is suggested that the transient and sustained contraction at 1 degree C is maintained by Ca2+ release from a cellular site, probably the cell membrane and it requires more calcium for the sustained tension.

2,4-Dinitrophenol↗

PubMed1984

Tension maintenance, calcium content and energy production of the taenia of the guinea-pig caecum under hypoxia.

When potassium (45.4 mM) was applied to isolated taenia of guinea-pig caecum, the muscle developed a rapid phasic and sustained tonic tension during aerobic conditions bubbled with 95% O2:5% CO2. Under hypoxic conditions bubbled with 95% N2:5% CO2, the taenia lost its ability to respond to high potassium with sustained tonic contraction, although it still showed rapid phasic contraction. Raising the glucose concentration from 5.5 to 55.5 mM in the presence of high potassium during hypoxia caused development of a sustained contraction which was 50% that of the muscle in aerobic conditions. In the presence of high potassium, the ATP content of the taenia decreased in hypoxia, but increased with increasing glucose concentration. When the taenia was exposed to hypoxic conditions, the amount of lactate released from the muscle increased. Raising the glucose concentration caused a further increase in lactate release in the presence of high potassium under hypoxia. Good correlations (gamma greater than 0.9) were observed between tension development, the ATP content and lactate release of the taenia in the presence of high potassium under hypoxia when the glucose concentration was varied between 5.5 and 55.5 mM. The total calcium content was increased by the presence of high potassium under aerobic conditions and the increase was abolished when the muscle was exposed to hypoxic conditions. Under hypoxia the total calcium content was not increased by raising the glucose concentration in the presence of high potassium. The cellular calcium content of the taenia, determined by the lanthanum method, was increased in the presence of high potassium under aerobic and hypoxic conditions, but the content was smaller in hypoxic conditions than in aerobic conditions. Under hypoxic conditions, raising the glucose concentration in the presence of high potassium did not affect the cellular calcium content. These results suggest that under hypoxic conditions the potassium-induced sustained contraction of the taenia is increased by raising the glucose concentration owing to increased ATP production through the glycolytic pathway, but not through mechanisms increasing the intracellular Ca concentration.

Adenosine Triphosphate↗

PubMed1984

Ejection timing as a major determinant of left ventricular relaxation rate in isolated perfused canine heart.

In the present study, we attempted to test the hypothesis that ejection timing rather than peak left ventricular pressure is a primary determinant of ventricular relaxation rate. In cross-circulated isolated canine hearts instantaneous left ventricular volume was controlled by a servo-pump system. To eliminate the effects of end-systolic and end-diastolic volumes and ejection velocity on left ventricular relaxation rate, these parameters were clamped, and only the ejection timing (onset and end of ejection) was altered, keeping the duration of ejection unchanged. Left ventricular relaxation rate was assessed by time constants of left ventricular pressure decline during the isovolumic relaxation phase calculated by both a semilogarithmic method, assuming that the asymptote is zero, and a best exponential fitting method. In 25 runs, a pair of contractions with ejection timings which differed by 53.1 +/- 2.1 (SE) msec were imposed, while end-systolic and end-diastolic left ventricular volumes and ejection duration were unchanged. All pairs of contractions demonstrated early ejection resulted in significantly (P less than 0.001) slowed relaxation as indicated by a prolongation of the time constants of isovolumic left ventricular pressure decay (delta 4.2 +/- 0.7, sec and delta 15.4 +/- 2.1 msec by semilogarithmic plot and the best exponential fit respectively), although peak left ventricular pressures (104.6 +/- 2.4 mm Hg) were even lower than those (116.6 +/- 2.8 mm Hg) in contractions with later ejection timing. Furthermore, in seven experiments, the heart was allowed to eject at five different timings; onset and end of ejection were progressively delayed in steps of 20 or 30 msec.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1984

The inhibitory effect of circulating lymphocytes on granulopoiesis in human cyclic neutropenia in vitro.

The effect of peripheral mononuclear cells (MNCs), lymphocytes and sera of a patient with typical cyclic neutropenia (CN) upon the normal colony forming unit in culture (CFU-C) growth was examined. MNCs and lymphocytes obtained during the recovery phase of the cycles inhibited CFU-C growth. In contrast, these cells obtained during the neutropenic phase revealed no suppressive effect. Serum inhibitors of granulopoiesis were not detected at any time during the cycle. These findings suggest that MNCs, especially lymphocytes, may be one of the contributory factors for the development of CN in this case.

Adult↗