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Biomedical subjects

Y Ikuta

Publications and source records attributed to Y Ikuta.

At least 181 records · Page 10Linked to original sources
PubMed1985

The duration of denervation and regeneration in nerve grafting. Quantitative histological assessment in the rat.

The common peroneal nerves of 15 male rats were severed and the rats were divided into four groups: immediate grafting (I group); grafting delayed one month (IM group); grafting delayed for three months (3M group) and 5 healthy rats were used as controls (control group). All the rats were sacrificed 5 months after grafting. Three morphological indices of the myelinated axons were evaluated, the mean number per unit area, their mean diameter and the axon packing density. The sites examined were, the proximal stump of the recipient nerve, the grafted nerve and the distal stump of the recipient nerve. When repair was carried out late there was atrophy of the axons within the proximal stump, indicating that delay affected axon regeneration as well as resulting in reduced activity in the distal stump. The "3M" group showed poor regeneration in comparison to the "I" group. However, in the "IM" group, the regeneration rate was similar to that of the "IM" group. Our results indicate that early secondary grafting should be considered when circumstances exist which make primary repair undesirable.

Animals↗
PubMed1985

Postoperative results of looped nylon suture used in injuries of the digital flexor tendons.

Primary or delayed suture was performed on 174 patients involving 234 digits with flexor tendon injury on the day of injury to a maximum of 486 days after injury during the past eight years from 1974. In the treatment a 4-0 or 5-0 looped nylon suture was used. Follow-up study was made on 121 patients involving 164 digits in whom at least six months had elapsed since the operation. The evaluation showed the results in 53.0% excellent, 15.3% good, 18.9% fair and 12.8% poor. Discussion is made of a number of factors which have effects upon the results of treatment of flexor tendon injury of the hand.

Adolescent↗
PubMed1985

Relationship between the number of digital nerves sutured and sensory recovery in replanted fingers.

The relationship between the number of digital nerves sutured and sensory recovery was investigated in 50 fingers of 33 patients, with follow-up of more than five years after replantation of the amputated fingers. Items of investigation were measurements of two-point discrimination (2PD) values and the threshold of touch sense. In cases of repair at the proximal phalanx, good sensory recovery was observed only with bilateral nerve repair. At the middle phalanx, the influence of the location of repair on sensory recovery was greater than that of the number of digital nerves sutured. Sensory recovery was better in those cases with repairs at a more distal location. Modes of sensory recovery were also studied.

Amputation, Traumatic↗
PubMed1985

Vascularized free flap transfer in the upper limb.

Free tissue transfer is quite an important and attractive procedure for reconstruction of an injured limb, especially an upper limb. A simple skin flap can be transferred to close an open wound of the limb, but a sensory flap or a special flap such as a nail-skin, tendon-skin, or muscle-skin flap is a much better donor for reconstructing the function of the upper limb. The muscle or muscle-skin transfer procedure should be highly valued as a means of restoration of motor function in those patients in whom all other measures have totally failed in the past. Sensory flap transfer from the foot is also highly valued as a method for reconstructing sensory and cosmetic problems of the hand and fingers.

Adult↗
PubMed1985

[UFT concentration in serum and tissues of patients with gynecologic malignant tumors following oral administration].

Oral UFT was given to patients with genital carcinoma prior to surgery. 5-FU, FT and uracil levels in the tumor site were then measured in the surgical specimens obtained. Simultaneous estimates of tissues and plasma 5-FU indicated that the amount of drug in the tumor site (0.227 +/- 0.117 micrograms/g wet weight) had a 6.3-fold increase in concentration compared with that in normal tissues (0.036 +/- 0.019 micrograms/g wet weight) and was approximately 13.4 times that of the peripheral circulation (0.017 +/- 0.007 micrograms/ml). The rate of increase in concentration of tissue 5-FU rose especially in carcinoma of the cervix (0.394 +/- 0.215 micrograms/g), corpus uteri (0.116 +/- 0.042 micrograms/g) and ovary (0.171 +/- 0.047 micrograms/g). In the case of carcinoma of the cervix, the concentration of 5-FU in the tumor site was found to be about 14.1 times higher in invasive carcinoma than in carcinoma in situ. 5-FU concentration in the tumor site showed a still higher level compared with normal tissue after the drug was administered, suggesting an accumulation of 5-FU within the tumor.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

A simple and rapid microdiffusion method for blood ammonia using a reflectance meter and a reagent plate, and its clinical evaluation for liver diseases.

A simple and rapid procedure using 20 microliters of whole blood is described for estimating blood ammonia by means of a reflectance meter using a reagent plate, which operates by the principle of microdiffusion. The most suitable condition for microdiffusion was at 37 degrees C for 15 min, in which the standard curve was linear, and reproducibility and recovery were sastisfactory. Blood ammonia levels by this method correlate significantly with the values by an ion exchange method in 72 patients with liver disease (r = + 0.970, y = 1.13x - 11). The method has a distinct advantage in sensitivity, simplicity, and rapidity for blood ammonia determination.

Ammonia↗
PubMed1984

Microvascular double clamp type A-II.

The features of a new double microvascular clamp are described. The device can be used to anastomose vessels ranging from 0.5 to 5.0 mm, without inflicting injury on the vessel wall.

Humans↗
PubMed1984

Reconstruction of the heel pad by flexor digitorum brevis musculocutaneous flap transfer.

We strongly believe that rotational transfer of a musculocutaneous island flap composed of the flexor digitorum brevis muscle is the best procedure currently available for covering and reconstructing the weight-bearing area of the heel and its posterior area from the histologic and functional points of view. Further, since it requires only one operation, we are confident that it is the ideal method.

Adult↗
PubMed1980

Free muscle transfer.

Eight cases of free muscle transfer with the use of microsurgical technique are reported, comprising five patients with Volkmann's contracture of the forearm, two with poliomyelitis, and one with an old brachial plexus injury. Operation was successful in the six patients with traumatic injuries, but proved unsuccessful in the two with poliomyelitis. Generally, the vessels and nerves of the recipient site were anastomosed with their counterparts in the grafted muscle. In one patient with an old brachial plexus paralysis in whom nerves in the recipient site could not be used, muscle graft an intercostal nerve transfer procedures were employed. In six cases, only muscle was transferred, and in two cases, the muscle together with an overlying skin flap was removed to reduce tension of the skin at the recipient site.

Adult↗
PubMed1979

Free muscle graft as applied to brachial plexus injury-case report and experimental study.

Active flexion of the elbow was restored in a case with complete brachial plexus injury of ten years' standing, by using free gracilis muscle graft with restoration of its vascular pedicle and the 3rd and 4th intercostal nerves for reinnervation of the graft. Experimental studies on the anterior tibial muscle of rats showed that the major bulk of the proximal part of the muscle by preservation of neuro-vascular bundle survived and was histologically viable, whereas, the major bulk of the distal part of the muscle replaced as a free graft necrosed and was replaced by fibrosis. A free graft with its intact circulation and neural supply could therefore provide a good proportion of viable muscle bulk for functional restoration in properly selected cases.

Animals↗
PubMed1978

Vascular pedicle fibular transplantation as treatment for bone tumor.

In 4 cases of bone tumor in which extensive bone defects resulted from removal of the tumorous focus, vascular pedicle free fibular transplantation was performed using microsurgical techniques together with filling the defects with iliac bone. Early bone union was achieved. Atrophy and fracture were avoided. Early postoperative physical therapy was possible. The vessels selected in the recipient site are dependent upon the location of the graft bed, but the anastomosed site of the vessels should be kept outside of the graft bed. It is important to plan the operation so as to avoid motion at the site of callus formation and tension at the anastomosis site.

Adult↗
PubMed1978

Method of bone fixation in reattachment of amputations in the upper extremities.

The object of secure bone fixation in the reattachment of amputated fingers is early motion. The use of specially designed screws and Kirschner wires is essential for this objective. This becomes even more important in the reattachment of fingers than the upper arm or forearm. If there should be non-union of the bone, an autologous bone graft should be applied as a secondary procedure.

Adolescent↗