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Biomedical subjects

Y Iinuma

Publications and source records attributed to Y Iinuma.

71 records · Page 4Linked to original sources
PubMed1992

Intestinal myoelectric activity and contractile motility in dogs with a reversed jejunal segment after extensive small bowel resection.

To evaluate the functioning and effectiveness of a reversed jejunal segment after extensive small bowel resection, we continuously measured the postoperative bowel motility (using bipolar electrodes and/or contractile strain gage force transducers) in interdigestive and postprandial conscious dogs at 2 to 5 weeks after surgery. The fasting duodenal migrating myoelectric (or motor) complex (MMC) occurred at markedly longer intervals in dogs with a 20-cm reversed jejunal segment created after 75% to 80% extensive small bowel resection (group 3) than in dogs that received extensive resection alone (group 2) or dogs that underwent construction of a reversed jejunal segment without bowel resection (group 1). The MMC arising from the duodenum was often interrupted at the jejunum above the proximal anastomosis and did not migrate smoothly to the reversed segment or terminal ileum in group 3. In addition, brief small discordant contractions were frequent in the reversed segment and the jejunum above the proximal anastomosis in group 3. The duration of the postprandial period without duodenal MMC activity was significantly prolonged in groups 2 and 3. These results suggest that the transit time and passage of intestinal contents were delayed and that the periodical MMC was disturbed in group 3. The delay of transit time was due to prolongation of the interval between duodenal MMCs, the interruption of MMC propagation at the jejunum above the proximal anastomosis, the dominance of MMCs that followed the inherent anatomical continuity of the bowel, and discordant movements across the proximal anastomosis. Functional obstruction could be a potential problem in a 20-cm reversed jejunal segment inserted after extensive small bowel resection.

Anastomosis, Surgical↗
PubMed1992

Isolation of Yersinia enterocolitica serovar O8 from free-living small rodents in Japan.

Yersinia species were isolated from 65 of 223 free-living small mammals trapped in 10 regions on Honshu Island in Japan. Of the 65 strains isolated, 1 was Yersinia enterocolitica serovar O3, 8 were Y. enterocolitica O5, 6 were Y. enterocolitica O8, 3 were Y. enterocolitica O9, and 1 was Yersinia pseudotuberculosis 4b. Of the six Y. enterocolitica O8 strains, five were positive for autoagglutination, Ca2+ dependence, and the 45-MDa virulence plasmid and showed high pathogenicity for mice.

Animals↗
PubMed1991

Flow cytometric DNA analysis of neuroblastoma: prognostic significance of DNA ploidy in unfavorable group.

Flow cytometric DNA content analyses were performed on samples of 54 patients with neuroblastoma. DNA aneuploidy was detected in 55.6% of the 54 patients. A high incidence of DNA aneuploidy was observed in patients with prognostically favorable variables such as age (less than 1 year), clinical stage (I, II, or IVs), and primary site (extraadrenal sites). DNA aneuploidy was predominant in surviving patients, even in those with unfavorable variables. In patients 1 year old or more, the survival rate among those with DNA aneuploidy was 58.8% compared with 28.6% in patients with diploidy. Likewise, in patients with advanced stage (III or IV) neuroblastoma, the survival rate among those with DNA aneuploidy was 63.2% compared with 30.4% in patients with DNA diploidy. It is concluded that DNA content analysis is of value in predicting the prognosis of patients with neuroblastoma.

Adrenal Gland Neoplasms↗
PubMed1989

[Strongyloidiasis following long-term corticosteroid therapy].

A 64-year-old man who was born and raised in Fukuoka Prefecture was admitted because of dyspnea. The chest X-ray film showed multiple pulmonary cysts. Corticosteroid therapy was given because of repeated episodes of dyspnea and wheezing. He complained of epigastric pain 20 months after administration of corticosteroid therapy. Gastro-endoscopic examination showed inflammatory changes of the gastric mucosa and the biopsy specimens revealed the filariform larvae of Strongyloides stercoralis. Furthermore, the larvae were frequently detected in both sputum specimens and stools. Pyrvinium pamoate was initially administered and was switched to thiabendazole because of the presence of hyperinfection. Although two cycles of thiabendazole treatment were given, the larvae were not eradicated. This case report suggests that long term corticosteroid therapy caused the hyperinfection syndrome of Strongyloides stercoralis in a patient who was auto-infected with this nematode.

Adrenal Cortex Hormones↗
PubMed1988

A case report of intrahepatic biliary atresia showing an unusual liver histology.

The extrahepatic biliary tract of a male infant, including both the left and right hepatic ducts, was proven to be patent up until his time of death, however, histologic examination of the liver revealed severe fibrosis of the portal areas with ductular proliferation, scattered bile thrombi, and subsequent biliary cirrhosis. In this case, since the obstructive lesion occurred at the secondary branching of the bilateral hepatic duct and because fewer changes were present in the interlobular bile ducts, it seemed possible to consider that the liver histology revealed findings similar to those of extrahepatic biliary atresia.

Bile Ducts, Intrahepatic↗
PubMed1981

The effect of gastric inhibitory polypeptide (GIP) on gastric acid secretion in dogs.

Inhibitory effects of gastric inhibitory polypeptide (GIP) on tetragastrin-stimulated gastric acid secretion were studied in five dogs prepared with both Heidenhain fundic pouches and simple gastric fistulae. In the first series of experiments graded doses of GIP, doubling from 0.25 to 2.0 microgram/kg-hr, were given intravenously with a background infusion of 4.0 microgram/kg-hr tetragastrin. In the second experiments graded doses of tetragastrin, doubling from 1.0 to 8.0 microgram/kg-hr, were given intravenously with an additional infusion of 0.5 microgram/kg-hr of GIP. GIP inhibited dose-dependently gastric acid secretion from Heidenhain pouches, but not from simple fistulae. Lineweaver-Burk and Dowd-Riggs transformations of dose-response data obtained with tetragastrin alone and tetragastrin plus GIP showed similar D50 (the dose required for half-maximal response). This indicates that GIP acts as a noncompetitive inhibitor of tetragastrin on acid secretion from the denervated stomach. GIP, however, had no inhibitory effects on acid secretion from the innervated stomach. The cause of this paradoxical effect of GIP remains unknown.

Animals↗
PubMed1981

Follow-up study of chronic pancreatitis.

The general profile of pain in the evolution of pancreatitis was analysed in relation to exocrine and endocrine pancreatic function in 127 patients with primary chronic pancreatitis followed up over 3 years. Pain decreased or disappeared in 67.8% and 55.9% of calcifying pancreatitis, respectively. While pancreatic exocrine function remained abnormal in spite of an improvement of pain in 72% of 18 patients with calcifying pancreatitis, it improved with the amelioration of pain in 64% of 25 patients with non-calcifying pancreatitis during the follow-up period. Alcohol abstinence seems most important for pain relief in patients with non-calcifying pancreatitis but not calcifying pancreatitis. Changes in glucose tolerance test were not related with those in pain. In calcifying pancreatitis, 69.2% of patients with calcifying pancreatitis were diabetic or became so, while 66.7% of patients with non-calcifying pancreatitis remained non-diabetic during the observation period.

Adult↗
PubMed1980

A simple and specific determination of trypsin in human duodenal juice.

A simple and specific method for the estimation of trypsin in human duodenal juice was described. The procedures are as follows: add 10 ul of undiluted sample, measure 2.0 ml of substrate solution of benzoylarginine p-nitroanilide (BAPNA) 0.5 mg/ml in a Tris buffer, incubate at 37 degrees C for 10 minutes, then terminate tryptic activity with 2.0 ml of 30% v/v acetic acid, and read absorbance at 410 nm by a spectrophotometer. Coexistence of bile pigments, chymotrypsin or elastase did not interfere the estimation of tryptic activity in duodenal juice. Reproducibility (both within- and between-assay variances less than 8%), recovery (mean of 100%) and stability of the enzyme activity after 3 weeks at -20 degrees C with glycerol (96% of the initial activity) were sufficient for clinical use. The amidase activity of trypsin estimated with BAPNA as substrate correlated well both to the esterase activity measured with p-toluenesulfonyl-L-arginine methyl ester (TAME) as substrate and to the immunoreactivity determined by radioimmunoassay in human duodenal juice. Good correlation between total outputs of amylase and trypsin were observed in 29 patients undergoing pancreozymin secretin test. The present assay technique will provide simple and reliable means of measuring trypsin in duodenal fluid and of mutual checks of the secretory capacity of pancreatic enzymes and will increase diagnostic accuracy of pancreozymin secretin test.

Amylases↗
PubMed1978

Pancreatic excretion test and barrier hypothesis in progression of chronic pancreatitis.

Simultaneous data of the pancreozymin-secretin test and the pancreatic excretion test with 5,5-dimethyl-2,4-oxazolidinedione DMO) were reported for 50 patients with chronic pancreatitis. The pancreozymin-secretin test was abnormal in 90% of the patients, while the pancreatic DMO excretion test showed abnormality in 100% of the patients. The dynamic process of pancreatic excretory dysfunction is discussed. Over 60% of patients with low to moderate grade chronic pancreatitis showed a discordant pattern of decreased DMO output with normal bicarbonate concentration or normal volume flow. Approximately 96% of patients with advanced grade chronic pancreatitis had a excretory pattern of decreased DMO output with low bicarbonate concentration and decreased volume flow. These findings may further develop a barrier hypothesis in chronic pancreatitis. In the early stage of chronic pancreatitis, when functional capacity of the duct is preserved fairly well, the extraductal barrier to the rapid DMO diffusion into the ducts (diffusion barrier) may be primarily responsible for impaired pancreatic DMO excretion. With progression of chronic pancreatitis, the intraductal barrier (outflow barrier) may become pronounced and precipitate pancreatic excretory dysfunction for DMO. The concept of pancreatic barriers may well serve to systematize major histologic alterations observed in chronic pancreatitis.

Adult↗
PubMed1977

A bleeding Meckel's diverticulum diagnosed by arteriography.

A case of Meckel's bleeding diverticulum diagnosed by emergent arteriography is presented. Arteriography revealed an extravasation of contrast medium into the distal ileum and an abnormal ileal artery which passed to the antimesenteric border of the ileum. The diverticulum was demonstrated by double contrast study of the small intestine. The merits of emergent arteriography and other examinations for diagnosing Meckel's diverticulum are discussed.

Adolescent↗