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Biomedical subjects

Y Ichikawa

Publications and source records attributed to Y Ichikawa.

At least 757 records · Page 42Linked to original sources
PubMed1983

[A case of vesical endometriosis].

Endometriosis of the bladder is an uncommon disease, but is common in gynecology. A 34-year-old woman visited us to be explored for the cause of microscopic hematuria and proteinuria, but gross hematuria had never been observed. Cystoscopic examination revealed a great number of pea size, hemispheric cysts on the trigone and the posterior wall of the bladder. Histopathological examination of the specimen taken by TU-biopsy showed vesical endometriosis. Danazol (17 alpha-Pregna-2, 4-dien-20-yno[2,3-d] isoxazol-17-ol) was given to induce menostasia and thereafter endoscopic findings and subjective symptoms were improved. Seventy-five cases of vesical endometriosis in the Japanese were reviewed.

Adult↗
PubMed1983

Effects of cholecalciferol (vitamin D3)-binding proteins and anti-cytochrome b5 immunoglobulin on cholecalciferol 25-hydroxylase activities of rabbit liver microsomes and mitochondria.

The effects of cholecalciferol (vitamin D3)-binding proteins and anti-cytochrome b5 immunoglobulin were studied on vitamin D3 25-hydroxylase activities of microsomes and mitochondria under various experimental conditions. The vitamin D3-binding protein in serum as well as in the liver postmicrosomal supernatant (cellular vitamin D3-binding protein), but not serum albumin and ovalbumin, stimulated vitamin D3 25-hydroxylase activities of microsomes and mitochondria. The optimum pH range was from 7.3 to 8.0. Anti-cytochrome b5 immunoglobulin did not affect microsomal vitamin D3 25-hydroxylase activity.

Animals↗
PubMed1982

The role of the sugar regions of components of the cytochrome P-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria.

Cytochrome P-450scc from bovine adrenocortical mitochondria was found to be a glycoprotein, similar to NADPH-adrenodoxin reductase. The role of sugar moieties of components of the cytochrome P-450-linked mixed-function oxidase system was investigated. The NADPH-ferricyanide reductase activity of NADPH-adrenodoxin reductase was not affected by neuraminidase treatment, but NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase and adrenodoxin was lost. Cytochrome P-450scc treated with neuraminidase could not be reduced by NADPH-adrenodoxin reductase and adrenodoxin, and the side-chain cleavage activity of cholesterol by the cytochrome P-450-linked mixed-function oxidase system was lost by neuraminidase treatment of cytochrome P-450scc or NADPH-adrenodoxin reductase or both. These results indicate that the sugar moieties of the components of the cytochrome P-450-linked mixed-function oxidase system are necessary for binding and attaching of the components and electron transport.

Adrenal Cortex↗
PubMed1982

Predictability of renal allograft prognosis during rejection crisis by ultrasonic Doppler flow technique.

Using the ultrasonic Doppler technique, renal blood flow was measured in 67 patients who underwent living related renal transplantation from January, 1976 to December, 1979. In 58 of 67 cases, 81 acute and 9 chronic rejection episodes occurred. In the initial stage of acute rejection, there are no particular changes in the pattern of systolic blood flow and by contrast marked changes of diastolic flow. The disappearance of the diastolic phase is indicative of an advanced stage of rejection, the reappearance indicative of recovery from rejection, and persistent loss accompanied by changes of systolic flow indicative of an unfavorable prognosis of rejection. In chronic rejection, there are rapid changes of neither systolic nor diastolic flow though the acceleration time in the systolic phase lengthens gradually. The ultrasonic Doppler flow technique for blood flowmetry of a transplanted kidney is a useful means of knowing the prognosis of rejection and provides an index for corticosteroid bolus therapy.

Adolescent↗
PubMed1982

Spasmolytic agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine derivatives.

N-[(Benzoyloxy)alkyl]-1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines and evaluated for their spasmolytic. Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine). The biological data have indicated some structure-activity relationships. Among these compounds, N-ethyl-N-[6-(3,4-dimethoxybenzoyl)oxy]hexyl]-1,2,3,4-tetrahydro-6-methoxy-2- napththylamine hydrochloride (63) was found to be the most active spasmolytic agent.

Animals↗