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Biomedical subjects

Y Hosobuchi

Publications and source records attributed to Y Hosobuchi.

At least 73 records · Page 4Linked to original sources
PubMed1978

Treatment of intracavernous extensions of pituitary adenomas.

Two cases of pituitary adenomas invading the cavernous sinus are presented. The technique of radical extirpation of intracavernous tumor is described. Clinical, radiologic and pathologic features diagnostic of invasive adenomas are discussed, as well as alternative treatments. Craniotomy for radical resection is recommended as primary treatment for tumors which can be identified preoperatively as invasive tumors.

Adenoma↗
PubMed1977

Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone.

Relief of intractable pain was produced in six human patients by stimulation of electrodes permanently implanted in the periventricular and periaqueductal gray matter. The level of stimulation sufficient to induce pain relief seems not to alter the acute pain threshold. Indiscriminate repetitive stimulation produced tolerance to both stimulation-produced pain relief and the analgesic action of narcotic medication; this process could be reversed by abstinence from stimulation. Stimulation-produced relief of pain was reversed by naloxone in five out of six patients. These results suggest that satisfactory alleviation of persistent pain in humans may be obtained by electronic stimulation.

Adult↗
PubMed1977

Opiate antagonist, naloxone, strongly reduces analgesia induced by stimulation of a raphe nucleus (centralis inferior).

The analgesic effects obtained in the cat by central inferior raphe nucleus stimulation are greatly reduced by the administration of a specific opiate antagonist, naloxone. In 12 of 16 cats analgesia, tested by pinches applied on the 4 limbs or the tail, was totally abolished. Analgesia tested by considering the increase of the threshold of the jaw opening reflex was reduced to 44% of the initial value. These results emphasize the relation existing between morphine analgesia and analgesia induced by central stimulation. To try to explain the effects of naloxone, one may suppose that central stimulation releases an endogenous morphine-like substance such as enkephalin.

Analgesia↗
PubMed1977

beta-Endorphin: behavioral and analgesic activity in cats.

beta-Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, beta-endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.

Analgesics↗
PubMed1977

beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats.

Tolerance to beta-endorphin developed acutely in cats if the administration of the peptide was repeated within the first 24 hr. The tolerance was reversed immediately by systemic administration of the serotonin precursor, 5-hydroxytryptophan. It was further shown that 5-hydroxytryptophan potentiates the analgesic effect of the subliminal dose of beta-endorphin.

5-Hydroxytryptophan↗
PubMed1976

Midbrain corectopia.

Intermittent corectopia was recently observed in a patient with bilateral, rostral midbrain infarction. Results from neuropathologic examination disclosed isolated but intact Edinger-Westphal nuclei. An explanation of midbrain corectopia centered on segmental innervation of the pupil by the Edinger-Westphal nucleus. In the presence of a paralyzed dilator muscle, select, central inhibition of sphincter tone resulted in an oval and eccentric pupil.

Adult↗
PubMed1975

Electrothrombosis of carotid-cavernous fistula.

The author describes a technique for directly closing a carotid cavernous fistula with electrothrombosis while preserving the intracranial arterial circulation. Copper wires are introduced through the superior ophthalmic vein or a frontotemporal craniotomy, and thus directly into the portion of the sinus into which the fistula drains; if posterior, into the posterior segment of Parkinson's triangle, if inferior, into the pterygoid plexus, and if anterior, through the sphenoparietal sinus and/or middle cerebral vein to the anterior-inferior portion of the sinus. A direct current is applied until a thrombus is confirmed angiographically and the wires are left in place. Four patients treated by this method are presented.

Adolescent↗
PubMed1975

Phantom limb pain. Treatment with dorsal column stimulation.

Good to excellent relief of phantom pain is reported in 5 of 6 patients by the use of dorsal column stimulation. Follow-up periods are 7 to 25 months. One failure occurred despite excellent pain relief; this patient could not tolerate application of the DCS apparatus to his chest wall. The authors review the physiology involved and some less successful series reported by others.

Adult↗
PubMed1975

Experience with dorsal column stimulation for relief of chronic intractable pain: 1968-1973.

Dorsal column stimulators (DCS) have been implanted in 130 patients with various chronic pain syndromes at the University of California, San Francisco, between 1969 and 1973. Preoperative psychiatric evaluation and percutaneous dorsal column stimulation testing were of value in rejecting those patients most likely to have unsatisfactory long-term results with DCS. Best results occurred in patients with phantom limb or peripheral nerve pain and worst results in patients with paraplegic pain, documented arachnoiditis, pancreatitis and arthritis. The need is stressed for careful preoperative selection and for close, prolonged postoperative care in a situation permitting access to multidisciplinary facilities for patient care.

Adult↗