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Biomedical subjects

Y Higuchi

Publications and source records attributed to Y Higuchi.

At least 253 records · Page 14Linked to original sources
PubMed1986

Renal oncocytoma.

Up to date only five cases of renal oncocytomas have been reported in Japan. We describe two cases of renal oncocytomas. Case 1: A 63-year-old woman, who had no urological symptoms, was pointed out of a cystic mass in the left kidney by chance. A resected kidney had a cystic tumor, which was well encapsulated and measured 6 X 7 X 8 cm. The tumor was unilocular and thick-walled cyst filled with bloody fluid. Histologically, the tumor was composed of oncocytes with eosinophilic granular cytoplasms that were packed with mitochondria. Case 2: A 70-year-old women died of malignant lymphoma and an autopsy was performed. The tumor was found in the right kidney by chance and measured 1 cm in diameter. The cut-surface of the tumor was uniform and tan-brown in color. Histologically, the tumor was composed of cells same as Case 1. We discuss the incidence of this tumor and the morphological characteristics of our cases.

Adenoma↗
PubMed1986

Cytotoxic and antitumor activity of a soluble fraction of Streptococcus pyogenes against S180 sarcoma cells.

A fraction (60F) having cytotoxic and antitumor activities was obtained from cell-free extract of group A Streptococcus pyogenes by precipitating with 50% to 60% saturated ammonium sulfate. 60F showed cytotoxic activity inhibiting the uptake of 3H-thymidine by S180 sarcoma cells and enhancing 51Cr-release from 51Cr-labeled cells. 60F showed also antitumor activity, depressing tumor growth and prolonging lives of mice bearing S180 sarcoma cells.

Adjuvants, Immunologic↗
PubMed1986

[An evaluation of carcinoembryonic antigen (CEA), beta 2-microglobulin (BMG), and immunosuppressive acidic protein (IAP) in the serum of primary lung cancer patients].

The correlation between histological type and serum CEA, BMG, and IAP was studied in 98 patients with primary lung cancer. In particular, the results showed that the positive ratio in squamous cell carcinoma was increased by measuring serum BMG or IAP simultaneously with serum CEA more than by measuring serum CEA alone. Also, when these values were compared with histological type, adenocarcinoma showed an elevation of the serum CEA level, whereas squamous cell carcinoma showed an elevation of the serum BMG or IAP level. It was suggested that serum CEA, BMG and IAP levels were closely correlated with the histological type in primary lung cancer.

Adenocarcinoma↗
PubMed1986

[Clinical evaluation of serum beta 2-microglobulin in squamous cell carcinoma of the lung].

The clinical usefulness of measuring serum beta 2-microglobulin (BMG) and squamous cell carcinoma-related antigen (SCC-Ag) was studied, and it was found that both were elevated in patients with squamous cell carcinoma of the lung. In squamous cell carcinoma, serum BMG was high in patients who were more than 65 years old, whereas it was not raised in those with other histological types or with benign respiratory diseases. This increase in BMG, however, was thought to correlate with the clinical stage rather than with aging. The rise of BMG was suggested, similar to the rise of SCC Ag, to be specific to squamous cell carcinoma of the lung.

Antigens, Neoplasm↗
PubMed1986

[Sigmoid septum causing left ventricular outflow tract obstruction: a case report].

A 67-year-old man with a sigmoid septum causing the left ventricular outflow obstruction by inotropic stimulation was reported. This patient was admitted to the Hospital of the University of Tsukuba because of chest pain. Phonocardiography revealed a systolic ejection murmur which was intensified by amyl nitrite inhalation. A carotid pulse tracing showed a mid-systolic dip and a secondary slow wave during amyl nitrite inhalation. M-mode echocardiography demonstrated neither systolic anterior motion of the mitral valve (SAM) nor mid-systolic closure of the aortic valve at rest. Two-dimensional echocardiography revealed a basal interventricular septum markedly protruding into the left ventricle (sigmoid septum). The remainder of the septum and the left ventricular free wall were not hypertrophied, and no enlargement of the left ventricular cavity was observed. During exercise tests, blood pressure dropped significantly. Cardiac catheterization showed a pressure gradient within the left ventricle with isoproterenol infusion and post-extrasystolic potentiation. These findings suggest that left ventricular outflow tract obstruction could occur in a patient with sigmoid septum by inotropic stimulation, producing a fall of blood pressure during exercise.

Aged↗
PubMed1986

[Effect of low density lipoprotein on intracellular cholesterol and progesterone production by monolayer cultured human luteal cells].

The purpose of the present study was to define the effect of low density lipoprotein (LDL) on progesterone (P) synthesis and on intracellular cholesterol content using monolayer cultured human luteal cells. When cultured in TC199 containing 10% lipoprotein poor serum (LPPS), P production decreased as culture time passed. In the presence of hCG, it also decreased, but slowly. In the presence of LDL, P production was kept at a higher level. Intracellular cholesterol content in luteal cells was measured by gas chromatography. The cholesterol content of luteal cells in a 4 day LPPS culture was higher than that in a 10 day LPPS culture. The cholesterol content in a 10 day LPPS culture with LDL was higher than that in a 10 day LPPS culture. The cholesterol content in a 10 day LPPS culture with hCG had a tendency to be lower than that in a 10 day LPPS culture, but there was no statistical difference (p less than 0.1). It was concluded that LDL was utilized in supplying intracellular cholesterol to luteal cells as a substrate for P synthesis. And in a state of LDL depletion in the medium, the luteal cells produced a small amount of P utilizing intracellular cholesterol. It was estimated from the results of the present study that hCG enhanced utilization of intracellular cholesterol.

Adult↗
PubMed1985

Relation between 201Tl to 67Ga uptake ratio and histological type in primary lung cancer.

Quantitative 201Tl and 67Ga scans were performed on 44 patients with primary lung cancer to ascertain the differences in 201Tl and 67Ga uptake by tumors; especially the crude uptake ratio (CUR) of 201Tl to 67Ga was evaluated in relation to histological type. Adenocarcinomas showed a CUR of 2.00 +/- 1.55, the greatest value among all histological types. Epidermoid carcinomas and oat cell carcinomas had CURs of 0.47 +/- 0.30 and 0.37 +/- 0.05, respectively, both showing significantly lower values than adenocarcinomas (P less than 0.01). On the other hand, adenosquamous carcinomas indicated a CUR of 0.91 +/- 0.15, an intermediate value between adenocarcinomas and epidermoid carcinomas (P less than 0.05). These results indicated that 201Tl and 67Ga uptake by lung cancer was closely correlated with histological type, and also suggested that 201Tl and 67Ga scans enabled various histogeneses of lung cancer to be visualized.

Adenocarcinoma↗
PubMed1985

Influence of arterial occlusion on hematocrit and plasma protein concentration of femoral venous blood in rabbit.

The changes of venous outflow (Qv), hematocrit (Hct), total plasma protein (Tp), electrolytes, crystalloid osmolality, PO2, PCO2, and pH were simultaneously measured in hindlimb preparation of anesthetized rabbits during 5 min occlusion of the femoral artery and the abdominal aorta and during the reactive hyperemia. During the occlusion of the femoral artery, Qv decreased to 66.4% at the end of the occlusion. Hct and Tp decreased slightly and then tended to progressively increase. PO2 showed an increasing trend following an initial decrease. During the occlusion of the aorta, Qv showed a continuous drop to 38.0%, while Hct and Tp declined to 95.4 and 93.8%, respectively. Qv, Hct, and Tp showed increase after the release of the occlusion of the femoral artery and the aorta. Crystalloid osmolality and K+ were observed to rise slightly. From these results it was suggested (1) that the increase of Hct and Tp which represents the hemoconcentration occurred during the reactive hyperemia and during the occlusion of the femoral artery, while the hemodilution occurred during the aortic occlusion, and (2) that the gradual increase of Hct and Tp during the occlusion of the femoral artery would be caused by the collateral blood flow.

Animals↗
PubMed1985

Separation of hemolytic substances from anticancer preparations of hemolytic streptococci.

Preparations 60F and 50F isolated from the cell-free extract of anticancer hemolytic streptococci possessed not only anticancer activity but hemolytic activity. Thus, the experiment to separate hemolytic substances from 60F and 50F were carried out. Three kinds of fractions were obtained from 60F or 50F by dissolving them in ammonium sulfate solutions of various concentrations. These fractions were named 60F-I, 60F-II and 60F-III, and 50F-I, 50F-II and 50F-III, respectively. 60F-I and 50F-I possessed neither anticancer activity nor hemolytic activity. 60F-II and 50F-II possessed only anticancer activity, and 60F-III and 50F-III possessed only hemolytic activity. Thus, hemolytic substances were separated from 60F and 50F, and it was demonstrated that the anticancer activity of hemolytic streptococci was not due to their hemolysins or hemolytic activity.

Ammonium Sulfate↗
PubMed1985

[Induction of ovulation with subcutaneous pulsatile administration of human menopausal gonadotropin].

Induction of ovulation with subcutaneous pulsatile (every 90 min.) administration of HMG (Pergonal) 75 or 150 IU/day using a portable pump (Nipro SP-3I) was performed in 3 PCO patients (6 cycles), 4 first grade amenorrhea (Am-I) patients (7 cycles) and 4 Am-II patients (4 cycles). All patients ovulated except one cycle of Am-I patients and one PCO woman conceived. In regard to the duration of administration and the total dose of HMG until ovulation, the administration of 150 IU/day (M +/- SD=15.2 +/- 5.0 days, 2280 +/- 774 IU) is superior to 75 IU/day (39.5 +/- 11.4 days, 3900 +/- 1357 IU), and there was no significant difference between this method and the daily intramuscular injection of HMG. The group treated with HCG in the luteal phase revealed a longer luteal phase (14.0 +/- 2.3 days) than the nontreated group (12.6 +/- 1.5 days). Ovarian hyperstimulation was observed in one case and subsided spontaneously after admission. There were no other side effects. In conclusion, this method has the following advantages: A high ovulation rate, comparable with daily intramuscular administration. It is a less painful procedure than daily intramuscular injection. It is possible for the patient to lead normal life, insertion and removal being easily done by herself.

Adult↗
PubMed1985

[Experience in local hyperthermia with using Therma Tech 2000. First report].

Studies of the effects of hyperthermia on neoplastic tumors have been developed on the basis of biology. At the some time, machines for the clinical application of hyperthermia have been slowly improved. The Therma Tech 2,000, however, unlike most other pieces of hyperthermia equipment, generates RF energy at 13.56MHz. In the present study, rabbits bearing VX2 tumors were given hyperthermia treatment and measurements of their temperatures were taken.

Animals↗