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Biomedical subjects

Y Hatayama

Publications and source records attributed to Y Hatayama.

29 records · Page 2Linked to original sources
PubMed1988

[Therapy of advanced neuroblastoma by the protocol of the Welfare Ministry used by the Sawaguchi Group].

Five patients with advanced neuroblastoma were treated with the protocol of the Welfare Ministry used by the Sawaguchi group. This protocol consists of cyclophosphamide (CPM), vincristine (VCR), 4'-O-tetrahydropyranyladriamycin (THP-ADM) and cisplatinum (CDDP). Two patients treated with this protocol as the first therapy obtained partial remission. Two patients who had obtained complete remission before the treatment with this protocol remained in complete remission after the treatment. One patient who had shown poor response to the therapy given before treatment with this protocol also showed poor response to the protocol. The most significant side effect with this protocol was myelosuppression, the severity of which was closely related to the dose of THP-ADM. Damage to the liver, kidney and heart was not very significant. We advocate that patients with advanced neuroblastoma can obtain complete remission with the aid of surgery and radiotherapy, etc., if they are treated with the present protocol as the first therapy.

Adrenal Gland Neoplasms↗
PubMed1987

[The possibility of surgery for aged patients with gastric cancer].

The possibility of surgery for aged patients with gastric cancer has been studied. Of 484 cases who underwent a gastrectomy, patients 70 years of age or over amounted to 86 (20%). The postoperative mortality rate for these aged patients was 3% and the postoperative mortality rate with hospital deaths added from other causes than operative deaths was 7%. The postoperative mortality rate of aged patients who underwent total or proximal subtotal gastrectomy improved during the period between 1975-1983 compared with the period between 1967-1974. In the second period, there were no deaths among aged patients who underwent an R3-operation and/or a combine operation. This fact shows that operative procedures have become safer for aged patients.

Adult↗
PubMed1984

[A study of multiple primary cancers of the stomach and other organs].

The incidence of associated synchronous or heterochronous malignant tumors in this series was 3.3% (21/633). These patients were found more in multiple cancer than single cancer of the stomach. A relatively high incidence of associated cancer of other organs was found with cancer of the large bowel and of the cervix in heterochronous cancer and cancer of the esophagus in synchronous tumors. The cumulative corrected 10-year survival rate of 15 cases of heterochronous tumors was 85.7%. On the other hand, six patients with synchronous tumor had more advanced cancer of other organs than gastric cancer, and four of them died due to cancer of other organs within two years. Both primaries should be found at the early stage and treated with curative surgery and/or radiotherapy.

Colonic Neoplasms↗
PubMed1984

Effects of surgical treatment and adjuvant chemotherapy studied by the depth of penetration in gastric cancer patients undergoing curative gastrectomy.

This report concerns 133 of 377 patients with gastric cancer who underwent curative gastric resection at the First Department of Surgery, Shinshu University Hospital, between January 1, 1967, and December 31, 1975. The effects of surgical treatment and adjuvant chemotherapy were investigated for every depth of penetration into the gastric walls. The 5-year survival rate was 41.7% among patients subjected to gastrectomy and 61.7% among those treated by curative gastrectomy. The 5-year survival rate decreased along with increased depth of invasion. Following surgical treatment, the 5-year survival rate was higher in the patients who underwent absolute curative resection than in those who were subjected to relatively curative resection. Extended radical gastrectomy is needed for patients with the depth of invasion through the muscularis propria. It is necessary to complement chemotherapy for patients with lymph node metastasis who are subjected to relative curative gastrectomy. In the patients with serosal invasion, papillary and tubular adenocarcinoma decreased and poorly differentiated adenocarcinoma increased substantially. The patients with poorly differentiated adenocarcinoma had a poorer prognosis than did those with tubular adenocarcinoma. Some ideas for the treatment of poorly differentiated adenocarcinoma are earnestly hoped for.

Adenocarcinoma↗
PubMed1984

[Clinico-pathological study and surgical treatment of cancer of the greater curvature of the stomach].

We retrospectively studied the clinicopathological features and surgical treatment of patients with cancer of the great curvature seen between 1967--1977. The incidence of cancer of the greater curvature in gastrectomized patients was 11% (31/281): this was the least frequent of four locations. Curatively resected patients, the five-year survival rate of those with cancer of the greater curvature was 50%, significantly lower than in patients with cancer of the anterior and posterior wall. Factors influencing the survival rate were age, size of the tumor, stage of the cancer, the presence of poorly differentiated adenocarcinoma, and relative curative resection. To improve the results of surgical treatment, early diagnosis and extended lymph node dissection are essential.

Adenocarcinoma↗
PubMed1979

Surgical treatment of the radiation injured bowel.

Over the last 10 years, 9 patients treated by surgical procedure for radiation injuries of the bowel were studied with the following conclusions: The damage to the small intestine caused by external irradiation leads to adhesion of the bowel, perforation and postoperative anastomotic dehiscence if the irradiated bowel is used in the anastomosis. Surgical treatment for the small intestine is resection of the damaged loop. In order to determine the extent of the resection it is important that during the operation fibrosis and obstruction of vessels in the submucosa and subserosa is examined by biopsy. On the other hand, rectal ulcer and/or rectovaginal fistula is chiefly caused by intracavitary application plus external irradiation. For these lesion Hartmann operation or colostomy is performed, and the postoperative course is uneventful.

Adult↗