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Biomedical subjects

Y Hashimoto

Publications and source records attributed to Y Hashimoto.

At least 739 records · Page 41Linked to original sources
PubMed1995

[A case of injured unerupted permanent tooth in a child].

Children with trauma visit frequently the department of oral and maxillofacial surgery. The treatment for injured permanent teeth is different from that for injured deciduous teeth. We have experienced a case of a 9-year-old boy with an injured unerupted immature permanent tooth with tooth crown fracture. When the tooth erupted gradually, fractured pieces were removed three times, and indirect pulp capping was performed. Three years after the injury eruption was almost completed and pulp was alive, even though the dental roentgenograph showed obliteration of the crown pulp cavity.

Child↗
PubMed1995

[Spinal intradural arachnoid cyst associated with enlarged filum terminale].

This is a report of a spinal intradural arachnoid cyst associated with an enlarged filum terminale. A 9-year-old female was admitted to our hospital complaining of lumbosacral pain. Neurological examination revealed no abnormal findings. CT scan showed a round shaped mass lesion in the right dorsolateral side of the spinal canal between the level of L1 to S1/2. The mass lesion disclosed isodensity and was not enhanced. A small low density mass lesion was visualized in the dural sac at the same level. MRI showed the mass lesion with low signal intensity on the T1-weighted image, and high signal intensity on the T2. The small mass lesion in the dural sac was demonstrated with low signal intensity on the T1 and T2-weighted image. In addition to this finding, Chiari malformation type I was disclosed. It was suspected that this mass lesion was extradural arachnoid cyst associated with an enlarged filum terminale. Osteoplastic laminotomy between L3 to S1/2 was performed, and an arachnoid cyst was found in the intradural space. It compressed the cauda equina and enlarged tough filum terminale. The cyst was removed subtotally, and the filum terminale was cut off. Postoperative course was uneventful and the lumbosacral pain disappeared. It was thought that this pain might be derived from the intradural arachnoid cyst, or the enlarged filum terminale.(ABSTRACT TRUNCATED AT 250 WORDS)

Arachnoid Cysts↗
PubMed1995

[A case of systemic lupus erythematosus associated with cerebral infarction and cerebral hemorrhage].

This is a report of cerebral infarction and cerebral hemorrhage derived from systemic lupus erythematosus. A 49-year-old male was admitted to our hospital due to dysarthria and supranuclear facial palsy. He had been suffering from SLE and medicated incompletely since 9 years prior to admission. A CT scan showed a small infarction in the left parietal area. An angiography revealed a tapering stenosis of the left carotid siphon and an occlusion of the left vertebral artery at the cisternal portion. On the 13 days after the admission, he complained of a high fever and right hemiparesis. The CT scan disclosed newly multiple small infarctions in the left parietal area. The angiography showed the progressing of the tapering stenosis at the left carotid siphon, and demonstrated the narrowing of the left superior temporal artery and ophthalmic artery in addition to the disappearance of a left posterior communicating artery. High dose of steroid was given to him, but cerebral hemorrhage and huge left cerebral infarction were complicated. On the 26 days after the admission, his general condition was worsened and died. It was considered that the cerebral infarction and hemorrhage might be derived from the vasculitis of SLE.

Cerebral Angiography↗
PubMed1995

NAD synthesis from nicotinic acid by the hepatocytes prepared from diabetic rats.

Hepatocytes were prepared from rats 3 and 7 days after a single injection of streptozotocin (50 mg/kg) or alloxan (40 mg/kg). Using the hepatocytes, NAD-and total pyridine nucleotide-syntheses from [carboxyl-14C]-nicotinic acid were investigated. The NAD content of streptozotocin- or alloxan-treated hepatocytes was not significantly different from that of the control hepatocytes. Syntheses of NAD and total pyridine nucleotides from nicotinic acid were significantly elevated 3 days after streptozotocin-injection but only total pyridine nucleotide synthesis was significantly higher 7 days after streptozotocin. Only total pyridine nucleotide synthesis was elevated 3 days after alloxan. Differences in the effects of the two diabetogenic agents and the physiological meaning of an increased NAD synthesis from nicotinic acid in the liver of diabetic animals were discussed.

3-Hydroxybutyric Acid↗
PubMed1995

[A case of the brainstem tactile hallucinosis due to pontine hemorrhage].

A 53-year-old man with hypertension was admitted to our hospital, for somnolence, horizontal gaze palsy, right hemiparesis and right sensory disturbance. Brain CT scan revealed a high density area from the left lower pontine tegmentum to the left tegmentum of the lower midbrain. As he became alert, he reported visual hallucination. Two weeks after onset of stroke, he complained tactile hallucination on his right half body with sensory disturbance. After disappearance of the visual hallucination, the tactile hallucination had been persisted. This is the first report of peduncular hallucinosis with long-persisted tactile hallucination due to brainstem bleeding. Tactile hallucination was suggested to be associated with sensory disturbance and extensive destruction of the brain stem tegmentum.

Cerebral Hemorrhage↗
PubMed1995

[Two cases of isolated ambient cistern hematoma after head injury].

This is a report of two cases of isolated ambient cistern hematoma after head injury. Isolated small hematomas in the ambient cistern after head injury are considered indirect evidence of brain stem injury. In such cases the initial neurological signs are often severe, but the ultimate prognosis is almost always good or excellent. Our patients showed hardly any neurological signs, and their head trauma was not very severe. Isolated ambient hematomas are the result of injury to small vessels or of mild contusions of the brain stem produced by the edge of the tentorium. In case 2, MRI revealed small, high signal intensity near the hematoma, and this sign was interpreted as evidence of mild brain stem injury. We think our patients had very mild brain injuries which were unaccompanied by diffuse axonal injury.

Brain Stem↗
PubMed1995

[Medical education in clinical anesthesia].

We use an angiofiberscope (AFS), an echocardiography (ECG) and a transesophageal echocardiography (TEE) as useful and productive tools for medical education perioperatively. We employed these monitors in the training of 5th-year medical students on general anesthesia in the operating room. A special intratracheal tube with small lumen (3 mm in diameter) for AFS (2.2 mm in diameter), was used for monitoring airway. Medical students are interested in and concentrate their attention on the monitor screen which has a continuous image from AFS. ECG was used routinely to evaluate preoperative cardiac function, while TEE was used during operation. These monitors play very useful role in medical education for students.

Anesthesiology↗
PubMed1995

[A case of adult pure yolk sac tumor of the testis achieving pathological complete response by chemotherapy].

We report a case of pure yolk sac tumor of the left testis in a 22-year-old male. He consulted a physician with left back pain and induration of his left scrotal content in December, 1992. Intravenous pyelography (IVP) revealed left hydronephrosis. Computerized tomography (CT) revealed para-aortic lymph node swelling and lung metastases. Left high inguinal orchiectomy was performed. Histopathological diagnosis was pure yolk sac tumor. After two courses of "COMPE" chemotherapy consisting of cisplatin, vincristine, methotrexate, peplomycin and etoposide, two courses of "high dose "COMPE" chemotherapy and three courses of "high dose COME" chemotherapy without peplomycin, he achieved a partial response (the regression rate of the pulmonary metastases and the retroperitoneal lymph node metastasis were 100% and 96.0% on CT, respectively) and the residual masses in the retroperitoneum were removed. Necrosis and xanthogranulomatous fibrosis were found in the resected material. The patient showed no evidence of disease two years after chemotherapy.

Adult↗
PubMed1995

Activators of protein kinase C but not of phospholipase C modulate adenylate cyclase-responses of normal pig epidermis.

It has been reported that keratinocytes possess phospholipase C (PLC)-mediated signal transduction system(s), that can be triggered by histamine, bradykinin, thrombin, platelet-activating factor (PAF), and epidermal growth factor (EGF)/transforming growth factor-alpha (TGF-alpha). Since the activation of PLC results in release of 1,2-diacylglycerol (DAG), the physiologic activator of protein kinase C (PKC) that modulates the epidermal adenylate cyclase, we investigated the effects of these PLC activating chemicals on the adenylate cyclase responses of dispase-separated normal pig epidermis. Among these chemicals and factors only histamine decreased the successive histamine-induced cyclic AMP accumulation and increased forskolin-, and cholera toxin-induced AMP accumulations. These effects were similar to those of PKC activators. However, in contrast to the PKC-activator-induced partial and receptor-non-specific desensitization, the histamine-induced desensitization was completely-inducible and specific to the histamine receptor system, and was not affected by the PKC inhibitor, H-7. Similar modulation of the epidermal adenylate cyclase was induced by other adenylate cyclase stimulators (epinephrine, adenosine and prostaglandin E2), but not by bradykinin, thrombin, PAF, or EGF. The combined addition of bradykinin, thrombin, PAF and EGF to the culture medium had no effect on the adenylate cyclase responses, either. Thus no evidence for receptor-agonist dependent PLC-induced modulation of the adenylate cyclase was obtained in the normal pig epidermis. Although keratinocytes might contain PLC-mediated signal transduction systems, that are triggered by histamine, bradykinin, thrombin, PAF, and EGF/TGF-alpha, none of the activators singly or in combination appear to activate PKC sufficiently for the modulation of adenylate cyclase responses of the normal pig epidermis.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗
PubMed1995

[A case of central retinal artery occlusion followed by cerebral infarction due to internal carotid artery disease].

Reported is a 68-year-old male with left central retinal artery occlusion (CRAO) followed by cerebral infarction due to left internal carotid artery disease. He was referred to our hospital diagnosed as having left CRAO. In view of severe stenosis of ipsilateral internal carotid artery by ultrasound duplex scan, carotid endarterectomy (CEA) was indicated. While waiting for the operation, he suffered from monoparesis in his right lower limb despite the administration of antiplatelet agents. Brain MRI showed cerebral infarction in the left frontal cortex. It was suggested that artery-to-artery embolism from the lesion of the internal carotid artery might be the common mechanism of CRAO and cerebral infarction in this case. According to theses results, CEA should be considered in patients with severe stenosis of the internal carotid artery before it is too late.

Aged↗
PubMed1995

[A case of transient ischemic attacks preceded by postprandial hypotension].

A 78-year-old man with a history of total gastrectomy, myocardial infarction and hypertension was admitted to our hospital because of frequent transient attacks of consciousness disturbance, aphasia and right hemiparesis after meals. His attacks occurred one to three times a day, 30 to 60 minutes after meals and lasted 120 to 180 minutes. At the time of the attacks his blood pressure decreased, but his pulse rate did not change. Cerebral angiography demonstrated atherosclerotic occlusion of the left internal carotid artery. There was no myocardial uptake of 123I-metaiodobenzylguanidine (MIBG). These results suggest that our patient had an autonomic dysfunction. Duplex carotid ultrasonography revealed that the blood flow velocity fell about 30% at the time of the attacks. His autonomic dysfunction and major artery occlusion may have produced a hemodynamic TIA following postprandial hypotension.

Aged↗
PubMed1995

[A case of recanalized basilar artery following basilar artery occlusion due to spontaneous dissection].

An 85-year-old man who did not have any previous history of heart disease was admitted to our hospital with the chief complaints of disturbance of consciousness, tetraparesis, and bilateral Babinski signs. On admission, intravenous digital subtraction angiography (DSA) showed bilatral vertebral arteries without filling the basilar artery. On the second hospital day, MRI showed a septum in the basilar artery, and no infarctions were noted in the brain stem. He gradually improved with heparin therapy. On the tenth hospital day, intravenous DSA disclosed filling of the basilar artery. On the sixteenth hospital day, conventional cerebral angiography revealed filling of the basilar artery from the left vertebral artery, and string sign and linear shadow (intimal flap) was noted in the basilar artery. He was diagnosed to have the basilar artery dissection. The patient became ambulatory and was discharged independently. This is very rare case of the basilar artery dissection with a good prognosis.

Aged↗
PubMed1995

[A case of internal carotid artery occlusion with recurrent amaurosis fugax].

Reported is the case of a 61-year-old man with a 2-year history of recurrent amaurosis fugax in the left eye attributable to left internal carotid artery occlusion. Cerebral angiography showed occlusion of origin of the left internal carotid artery, collateral pathway from the left external carotid artery to the left internal carotid artery through the left ophthalmic artery, 25% stenosis of the right internal carotid artery, and collateral pathway to left internal carotid arterial system through the Willis ring. We concluded that emboli through the left external carotid artery from the site of left internal carotid artery occlusion might cause amaurosis fugax in this case, because of the findings described below. 1. sudden onset and rapid recovery of visual loss. 2. ipsilateral occlusion of the internal carotid artery and retrograde filling of the ophthalmic artery by cerebral angiography. 3. the diminishment of attacks of amaurosis fugax by the administration of antiplatelet drug.

Blindness↗
PubMed1995

Synthesis of oligopeptides as polynucleotide analogs.

Several dipeptides which have a nucleic acid base in their side chains were designed as water-soluble nucleotide analogs. Amino acids having a uracil or adenine moiety in the gamma-position were synthesized and were connected with another amino acid (spacer) to afford dipeptides. The oligopeptides were prepared from the dipeptides as monomer units. Although all the oligopeptides having uracil moieties examined were water-soluble as expected, these exhibited no hypochromic effect with poly A or poly dA. Contrary, the oligopeptides with adenines exhibited large hypochromicity (ca. 30%) base-specifically with poly dT or poly U.

Molecular Structure↗