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Biomedical subjects

Y Harada

Publications and source records attributed to Y Harada.

At least 865 records · Page 48Linked to original sources
PubMed1977

Comparison of the mode of immunopotentiating action of BCG and wax D. I. Effect on the immune response to SRBC.

The immunopotentiating action of BCG and wax D was comparatively evaluated as the immune response to sheep red blood cells (SRBC) in mice. The immunopotentiation of BCG varied with the interval between its priming and subsequent antigen injection. BCG increased delayed type hypersensitivity (DTH) at early stage but enhanced antibody formation at later stage. DTH reached its maximum about 5 weeks after BCG inoculation. In contrast, wax D increased antibody formation at early stage but increased DTH at later stage. Freund complete adjuvant (FCA) containing wax D stimulated much antibody formation rather than induction of DTH in mice. Cord factor and even Drakeol 6VR could induce DTH at early stage of prior inoculation.

Adjuvants, Immunologic↗
PubMed1977

Comparison of the mode of immunopotentiating action of BCG and wax D. II. Effect on the methylcholanthrene carcinogenesis.

The effects of BCG and wax D on methylcholanthrene (MCA) carcinogenesis in mice were studied. BCG given 8 weeks after MCA administration conferred a significant protection against carcinogenesis. When given either on the same day as MCA injection or 4 weeks after MCA, BCG slightly increased tumor incidence. Wax D provided a marked protection against tumor development when given 4 weeks after MCA. An enhanced tumor development was obtained, when wax D was administered either on the day of MCA injection or 8 weeks after MCA. These results indicated that the effects of BCG and wax D on MCA carcinogenesis varied with the timing of administration. When BCG and wax D increased the level of delayed type hypersensitivity (DTH) at the initiating time of tumor development, a protection against carcinogenesis was obtained. On the other hand, BCG and wax D enhanced tumor development, when it increased antibody formation at the time of initiation of tumor development.

Animals↗
PubMed1976

Responses of Midbrain raphe neurons to local temperature.

The effect of heating and cooling in the midbrain on the unit activities of midbrain raphe neurons in the rat was observed. Out of 24 raphe units studied, 14 units responded to a rise in midbrain temperature with an increased rate of firing. The remaining 10 units did not respond to temperature changes between 34 and 41 degrees C. The result is consistent with the idea that the heat-induced increase in brain serotonin turnover is mediated by an increased firing rate of midbrain raphe neurons.

Animals↗
PubMed1976

Midbrain neuronal responses to local and spinal cord temperatures.

Water-perfused thermodes were implanted over the lumbothoracic spinal cord and unilaterally in the midbrain of urethan-anesthetized rabbits. Single-unit activities were recorded with steel microelectrodes from the thermosensitive neurons in the midbrain reticular formation (MRF), and the effects of heating and cooling of the spinal cord were studied. Of 38 cold-sensitive MRF neurons studied, 7 units decreased their firing rate upon elevation of spinal cord temperature (Tsc) and 3 units showed the opposite type of response to Tsc. The remaining 28 cold units were not affected by the changes in Tsc between 30 and 43 degrees C. Of 17 warm units, 3 units increased and one unit decreased the firing rate during spinal cord heating. These results suggest that the temperature signal arising from thermosensitive structures in the spinal cord may be transmitted to some of the locally thermosensitive neurons in the MRF.

Animals↗
PubMed1976

Scanning electron microscopy of the endolymphatic sac epithelium.

In this study, scanning electron micrographs of the dog endolymphatic sac surface epithelium are presented. According to our morphological findings, three portions were recognized, the proximal, intermediate and distal part. The intermediate or 'rugose' portion was found the most differentiated where two types of cells were identified. These cells were seen to have many of the criteria for fluid absorption and phagocytosis. In man, alteration in the ability of these cells may lead to endolymphatic hydrops.

Animals↗
PubMed1976

Rhinoscleroma: a scanning electron-microscopic study.

Nasal biopsies from 6 patients with rhinoscleroma were studied by scanning electron microscopy. Numerous bacilli of different sizes were found on the epithelial surface. Few bacilli with thin spiral terminal cilia were seen over the surface of large protruding non-epithelial cells. These cells appeared to be the Mikulicz cells migrating from the tunica propria to the epithelial surface through small ulcerations. In the tunica propria, Mikulicz cells containing numerous bacilli were observed. In 4 patients, round bodies and long tubular structures were found on the epithelial surface. These bodies were suggested to be fungi, yet their exact nature and their relation to Klebsiella rhinoscleromatitis bacilli need further investigation.

Adult↗