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Biomedical subjects

Y Harada

Publications and source records attributed to Y Harada.

At least 613 records · Page 34Linked to original sources
PubMed1988

[Nonpenetrating brachiocephalic arterial injury].

The injury of brachiocephalic artery is uncommon in the blunt trauma and sometimes it was accompanied by other organ damages. We reported a case and reviewed 47 cases in literature. A 28-year-old woman was transferred to our hospital with the blunt chest trauma and the cerebral infarction due to the traffic accident. The cineangiogram showed complete obstruction at the middle portion of brachiocephalic artery and the subclavian steal-carotid recovery phenomenon. Thirty days after trauma, the operation was performed under the monitoring of right superficial temporal arterial pressure. The vessel with intimal defect was plugged by a clot and it was replaced with a Gore-Tex graft during simple occlusion of the right carotid, subclavian and brachiocephalic arteries without any monitoring pressure change. The postoperative course was uneventful and the symptom improved. The review decided that the main cause of the injury is traffic accidents and the cineangiogram is important to find the arterial damage and the monitoring of superficial temporal arterial pressure is helpful to avoid the brain ischemia during operation.

Accidents, Traffic↗
PubMed1988

Long-term results of the clinical use of an expanded polytetrafluoroethylene surgical membrane as a pericardial substitute.

We report our long-term experience with the clinical use of an expanded polytetrafluoroethylene surgical membrane as a pericardial substitute in 61 children with congenital heart disease. Twenty-three of these children underwent reoperation successfully, and advantages of the membrane in resternotomy and dissection of the pericardial space were recognized. We have so far experienced no major complications from the use of an expanded polytetrafluoroethylene surgical membrane. We conclude that the clinical use of an expanded polytetrafluoroethylene surgical membrane as a pericardial substitute is valuable in children with congenital heart disease who are expected to undergo reoperation in the near future.

Child↗
PubMed1988

[A valved conduit replacement for a calcified homograft 12 years following a Rastelli operation: a case report].

A 25 year-old male with transposition of great arteries, ventricular septal defect and pulmonary stenosis successfully underwent Rastelli procedure with aortic homograft in 1969. After the procedure he grew up and became an engineer without any complaints. However, gradually his homograft degenerated with calcification and the pressure gradient between pulmonary artery and right ventricle increased to 77 mmHg in systolic phase. Twelve years after the conduit repair, we operated upon and enlarged the ventricular septal defect, repaired the residual interventricular shunt, removed his homograft and, replaced it with the Hancock valved conduit from the right ventricular outflow tract through cardiopulmonary bypass. On postoperative cardiac catheterization, the pressure gradient decreased, and the patient returned to his work.

Adult↗
PubMed1988

[Aortic valve replacement in children associated with enlargement of aortic annulus].

Between February, 1983 and August, 1987, twelve children, aged from 2 years to 16 years, underwent aortic valve replacement associated with enlargement of aortic annulus successfully. According to the form of the left ventricular outflow tract obstruction, enlargement of aortic annulus was performed by Konno procedure in eight cases, by Nicks procedure in three cases and by Manouguian procedure in one case. In Manouguian procedure, mitral valve replacement associated with enlargement of mitral annulus was carried out simultaneously. In Konno and Manouguian procedures, the diameter of aortic annulus was enlarged from 180% to 200% compared with the original annular size, whereas in Nicks procedure, the diameter was enlarged around up to 110%. St. Jude Medical valve, of which size ranged from 21mm to 25mm, was employed in these procedures. All these children survived operation, and the post-operative follow up period ranged from 1 month to 55 months. There was one late death eleven months after Konno procedure because of respiratory failure resulting from pulmonary hypertension which persisted postoperatively. The remaining eleven children are surviving well after procedure. These results suggest that aortic valve replacement associated with enlargement of aortic annulus is an acceptable procedure in children with small aortic annulus or sub-aortic stenosis.

Adolescent↗
PubMed1988

[Hoarseness after removing a cervical schwannoma--a case report].

A 54-year-old man complained of asymptomatic lump in the right parotid gland region. The lump was well movable and had no fixation to the adjacent tissue. The lump was surgically extirpated and histological sections of the lump revealed benign schwannoma. In view of postoperative evidence of hoarseness, it was thought the tumor might be arose from the cervical vagal nerve. The hoarseness has been observed for one year after operation without any improvement. A statistic study on the hoarseness after removing the cervical tumor was done by sending out questionnaires to the members of the council of the Japan Surgical Society. Of 270, 180 replies were obtained and 67.2% of the members answered that they did not have any knowledge about the hoarseness after removing the cervical tumor.

Cranial Nerve Diseases↗
PubMed1988

[Clinical evaluation of sultamicillin fine granules in lower respiratory tract infection].

Sultamicillin (SBTPC) fine granules were given to 15 patients with respiratory tract infections at a dose of 375 mg 3 times a day. The results were excellent in 4 patients, good in 8, fair in 1 and poor in 2 with an efficacy rate of 80% which is comparable to that of SBTPC tablet (Unasyn tablet). One patient complained of difficulty in swallowing the drug probably due to its fine granular nature. No side effects nor abnormal laboratory test values due to this drug were observed in any of the patients enrolled in this study. From the above results, SBTPC fine granules seem to be useful in the treatment of pediatric and elderly patients who sometimes have difficulties in taking tablets.

Administration, Oral↗
PubMed1988

[A case of rupture of a posterior pancreaticoduodenal artery aneurysm].

A 75 year old man complaining of right upper abdominal pain was admitted to our hospital. He became shocked with hypotension and cold sweat, and immediately underwent operation. Laparotomy revealed massive hemorrhage in the retroperitoneal region, particularly in the right upper space. It was derived from the rupture of the posterior pancreaticoduodenal artery aneurysm. The arterial trunk was ligated above and below the aneurysm and the aneurysmectomy was carried out. The patient recovered and was discharged from the hospital 56 days after operation. There was no other visceral artery aneurysm and the etiology of this aneurysm was unknown. Four cases of pancreaticoduodenal artery aneurysm have been reported in Japan and three of them were operated, but this is the first surgically resected case for the rupture of pancreaticoduodenal artery aneurysm with success.

Aged↗
PubMed1988

[Clinical study on the effect of adjuvant immunochemotherapy using OK-432 and 5-FU in pharyngeal and laryngeal cancers].

A randomized controlled trial was carried out on 38 pharyngeal and 59 laryngeal previously untreated cancers to evaluate the effects of adjuvant immunochemotherapy using 5-FU with and without OK-432. After each fundamental therapy, 5-FU was given orally at a dose of 200-300 mg/day for more than a year. OK-432 was intracutaneously administered at a dose of 5KE once a week for more than a year. Three-year survival rates and disease-free intervals were estimated for the two groups. In cases of pharyngeal cancer, the 3-year survival rate was 58% in both groups and the disease-free interval rates for up to 3 years after the fundamental therapy was 49% in the OK-432 + 5-FU group and 52% in the 5-FU group. These results showed no statistically significant difference. In laryngeal cancers, the 3-year survival rate was 96% in the OK-432 + 5-FU group and 82% in the 5-FU group. These results also showed no statistically significant difference. The disease-free interval rates were 87% in the OK-432 + 5-FU group and 64% in the 5-FU group, revealing a statistically significant difference (p less than 0.1). This suggests that OK-432 is more effective in producing a higher survival rate in cases of laryngeal cancer.

Administration, Oral↗
PubMed1988

[Carcinoid tumor of the ileum with intestinal tuberculosis--report of a case].

A 65-year-old woman visited our hospital, complaining dizziness and abdominal pain. Positive fecal occur blood and an iron-deficiency anemia were found. An investigation of the GI tract was performed, and enteroclysis revealed three stenotic lesions in the ileum, the most distal one having an irregular edge. A superior mesenteric angiogram showed tumor stain and encasement in the ileal region. On laparotomy, a large tumor and multiple stenosis were found in the ileum. Histological examination of the resected specimen confirmed the diagnosis of a carcinoid tumor and healed tuberculosis of the ileum.

Aged↗
PubMed1988

Minimum structural unit required for energy transduction in muscle.

The sliding of actin filaments was directly measured along single-headed myosin filaments on which the density of the heads was widely varied, using video-fluorescence microscopy. The results showed that the double-headed structure of myosin is not essential for inducing the sliding movement of actin filaments. The minimum number of myosin heads required for supporting movement of actin filaments at a maximum velocity of 5 micron/s at 23 degrees C was estimated to be 4, at most 16. This led to the conclusion that the sliding distance of actin filaments induced during a single ATP hydrolysis cycle is probably 160 nm or more, at least 40 nm under unloaded conditions.

Actin Cytoskeleton↗