[Incidence of numbness and pain of the hand, back, lumbar region and feet].
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Back Pain↗
Biomedical subjects
Y Harada
Publications and source records attributed to Y Harada.
The elementary process in the actomyosin energy transduction system.
The sliding distance of an actin filament induced by a myosin head during one ATP hydrolysis cycle was determined by measuring minimum length of actin filaments moving on myosin-coated glass surface as fast as long ones and the ATPase rate during sliding. The results indicate that the sliding distance is greater than 100nm, suggesting that the mechanical reaction can occur many times during one chemical (ATP hydrolysis) cycle.
Actins↗
[Experimental studies of healing process on compound blocks of hydroxyapatite (HAP) particles and tricalcium phosphate (TCP) powder implantation in rabbit mandible--comparison of HAP/TCP ratios and plastic methods].
Bone substitutes consisting in 2 mold-poured compound blocks of HAP:TCP (mixing ratio 1:1) and HAP:TCP (mixing ratio 3:1) and one compound block (mixing ratio 1:1) prepared in a rubber press were implanted in defective areas in rabbit mandibles. The conditions under which the implants were made were identical in all cases. Histological studies and contact microradiography performed on ossification of the surfaces and surroundings of each block, ossification maturation, and the absorptive process of TCP and the extent to which it was replaced by new bone produced the following results. 1. At one week after surgery, new bone had grown along the surfaces of the blocks. It remained in tight contact with the block surfaces as it matured. These findings make it clear that the blocks are superior in terms of biocompatibility and osteoconduction. 2. In the course of time, in the 2 mold-poured compound blocks, the hydrated parts of alpha-TCP, which was a binder, were absorbed and replaced by new bone. At forty eight weeks after surgery, new bone had grown into the pores of the HAP particles to form a bone-HAP composite. 3. Even as late as forty eight weeks after surgery, some of the hydrated parts of alpha-TCP remained unabsorbed; and mold-poured compound blocks (mixing ratio 1:1) retained their shapes. On the other hand, in the mold-poured compound blocks (mixing ratio 3:1), the hydrated parts of alpha-TCP were almost absorbed and replaced by new bone in forty eight weeks after surgery. Amounts of the binder alpha-TCP present appeared to cause differences in biological reactions. 4. In the case of compound blocks of HAP:TCP (mixing ratio 1:1) formed in a rubber press, the binder was beta-TCP. Because of its high sintering properties and great density, absorption and ossification were gradual; and the blocks retained their complete original forms even in forty eight weeks after surgery. 5. Past reports have claimed that beta-TCP is absorbed in the initial stage. But, as is clear from experiments with compound blocks formed by means of a rubber press, even when the binder is beta-TCP in all cases, absorption speed differs depending on the mold used. 6. These results indicate that compound blocks of HAP and TCP used as artificial substitute bone materials have excellent properties of biocompatibility, osteoconduction, and plasticity. In addition, however, they make it clear that, owing to differences in absorption of the binder, ossification speed, and dynamic properties from block to block, it is essential to use the mold that properly suits conditions prevailing in the defective area.
Animals↗
[Radioreceptor binding assay of Ca antagonist].
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Animals↗
[Physicochemical characteristics of new reinforcement ceramic implant].
Investigation of the physicochemical characteristics of reinforcement ceramic implant materials which have needle crystal produced the following results. 1. Simple diopside and hydroxyapatite with diopside have enough dynamic intensity of both the implant in point of bending intensity and the breaking toughness. 2. Simple diopside and hydroxyapatite with diopside go well as biomechanics because of their Young's modulus being close to the surrounding bone. 3. Diopside in pseudo-body fluid developed hydroxyapatite on surface like bioglass, and this resulted in high possibility of direct bond with bone. 4. The results of this study indicate that the diopside and hydroxyapatite with diopside have enough dynamic intensity and are bioactive dental implant materials.
Ceramics↗
[Thermal analgesia following intrathecal capsaicin administration in rats--detailed measurements of thermal analgesia over the lower body by a thermal probe].
This study was undertaken to examine the thermal pain thresholds over a wide area of the lower body surface following the intrathecal administration of capsaicin in rats. Thermal nociceptive thresholds measured under light halothane anesthesia were determined as skin twitch or escape response latencies to the heat stimulation (52.0 degrees C) by a thermal probe. Capsaicin (50 micrograms in 10 microliters) was injected through a chronically implanted catheter whose tip was near the lumbar enlargement of the spinal cord. The hot-plate test (52.0 degrees C) was also performed in all rats tested. Increase in thermal pain thresholds were consistently observed in the low back and abdominal region, while the hind paws did not always respond with prolonged skin twitch or escape latencies. Intensities of thermal analgesia at the sole of hind paws measured by hot-plate test correlated well with those by thermal probe test. In conclusion, intrathecal capsaicin definitely produced thermal analgesia, but its intensity was considerably variable in the hind paws. These results are in keeping with our previous finding that there was much variability in the effect of capsaicin assessed by the hot-plate test, indicating a possibility that capsaicin does not spread uniformly in the CSF because of its water insolubility or difficulty in penetrating to the large nerve roots innervating the hind paws.
Analgesics↗
[Experimental study on the changes in circulatory kinetics due to an increase of intraabdominal pressure: the effective monitoring of the pressure of inferior vena cava].
We examined the change in circulatory kinetics due to an increase in intraabdominal pressure by adding pressure quantitatively to the abdominal wall by means of the manchette technique by using mongrel dogs, and obtained the following results: 1) By adding to the pressure to the abdominal wall, the pressure of inferior vena cava at the confluence of right and left common iliac veins showed a significantly higher value (p less than 0.05) than those at other 4 areas of the vena cava from just above the diaphragm to the above confluence. 2) All the dogs in the group with 20mmHg pressure survived for 24 hours, while those in the group with 40mmHg pressure died in all after survival between 13.8 +/- 2.05 hours. 3) The pressures of the inferior vena cava at the confluence of right and left common iliac veins with 20 and 40mmHg showed no significant difference immediately after the pressurization, but thereafter showed a increasing tendency in the group with 40mmHg (p less than 0.05). This increase in the pressure of the inferior vena cava lead to peripheral circulatory insufficiency. 4) The measurement of the pressure of the inferior vena cava at the confluence of right and left iliac veins in case of increased intraabdominal pressure seems to be an effective index for the risk of intraabdominal pressure.
Abdomen↗
[Preoperative diagnosis of a case of biliobiliary fistula].
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Biliary Fistula↗
[Approach to mechanism of muscle contraction by molecular micromanipulation].
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Actin Cytoskeleton↗
Modification of 5-methylcytosine in DNA and its relation to mutagenesis.
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5-Methylcytosine↗
[Gaze-evoked eyelid closure. Report of two cases].
Various types of associated movements of eyeballs with other cranial muscles have been described in the literature. Only a few observations, however, have been reported on the relation of ocular movements and facial muscles innervated by the facial nerve, especially the orbicularis oculi muscles. We report two cases presenting gaze-evoked involuntary contraction of the orbicularis oculi muscle and unilateral eyelid closure. Case 1 was a 38-year-old housewife who was admitted to our hospital because of gait disturbance and sensory deficits below the neck. She had a 5-year history of left facial palsy, disturbed horizontal eye movements, retrobulbar optic neuritis, spastic paraparesis and bladder and rectal disturbances, some of which had relapsed a few times. Neurological abnormalities were summarized as follows: bilateral pale discs, right Horner's sign, horizontal nystagmus, left facial nerve palsy of peripheral type, spastic paraparesis with left-sided predominance, sensory disturbances below the third cervical segment, truncal and limb ataxia, and bladder and rectal disturbances. Gaze-linked synchronized contraction of the left facial muscles was observed and on the left lateral gaze marked spasm of the left orbicularis oculi muscle with occasional lid closure was evoked. Case 2 was a 72-year-old female with cerebellar hemorrhage. Neurological abnormal findings included mild disorientation, meningeal irritation signs, horizontal nystagmus on lateral gaze, reduced response of reflex eye movement to the left, minimal weakness of the left facial muscles, ataxic dysarthria, mild left hemiparesis and hemisensory deficits with face, truncal and limb ataxia. She could move eyeballs to any direction but with effort to the left.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗
[Surgical treatment of the prosthetic valves in reoperation].
Surgical treatment and problems in patients required reoperation for malfunctioning prosthetic valves are reviewed in our institute. The cinefluoroscopy and pulse doppler echocardiography were helpful for diagnosis of artificial valve dysfunction. In recent two decades valve replacement were performed in 382 cases and number of re-implanted valve were 469. Among them the cases of reoperation were 21 and reimplanted valves were 25 (5.6%); 4.7% in aortic, 5.0% in mitral, 6.7% in tricuspid position. Three cases of those patients had three operations. Main causes of reoperation were primary tissue failure in Carpentier-Edwards porcine xenograft (6 cases, 23%) and cloth wear in Starr-Edwards ball valve (9 cases, 38%) and thrombosis in St. Jude Medical bi-leaflet valve (3 cases, 15%). In most cases St. Jude Medical valve were chosen for the alternative prosthetic valve in reoperation. We applied IABP support to seven patients for severe low cardiac output syndrome after the operation and overall mortality was 24% in reoperation. It concluded that St. Jude Medical valve may be most reliable because of low incidence of postoperative complication in our institute.
Adult↗
[A case of jugular foramen meningioma in a child].
The common tumors originating in the jugular foramen are chemodectoma and schwannoma. Jugular foramen meningioma is extremely rare. Review of the literature revealed only seven reported cases of this tumor. The authors present a child case of jugular foramen meningioma with intra and extracranial extension. A 9-year-old boy was admitted to the Department of Neurosurgery, Hiroshima University School of Medicine on March 20, 1985. Since the age of 3, the patient had hoarseness and was found to tilt his neck when he shouted. Since the age of 6, he was found to nod when he swallowed. At the age of 8, he developed swallowing difficulties. On admission, his general condition was unremarkable except for his lean build (126 cm in height and 23 kg in weight). An elastic hard and immobile mass was palpable in the left upper neck deep in the atrophic sternocleidomastoid muscle. Neurological examination revealed involvement of the ninth, tenth, eleventh, and twelfth cranial nerves. A plain skull roentgenogram and laminogram revealed hyperostosis around the left jugular foramen, and narrowing of the canal. CT with contrast enhancement revealed a high density mass in the left cerebellopontine angle extending through the jugular foramen to the left parapharyngeal space. Cerebral angiography did not show any abnormal findings except for complete blockage of the left sigmoid sinus. On April 4, 1985, subtotal removal of the intracranial tumor was performed using suboccipital craniotomy. Then, on July 3, 1985, the left parapharyngeal tumor was excised through a cervicofacial incision. Finally the residual tumor in the jugular foramen was excised using suboccipital approach on August 18, 1986.(ABSTRACT TRUNCATED AT 250 WORDS)
Brain Neoplasms↗
[2 cases of intermittent hydronephrosis--usefulness of ultrasonography].
Case 1: An 8-year-old boy consulted our clinic complaining of left flank colicky pain. He had a past history of the same episode. Ultrasonographic study was promptly performed. Left hydronephrosis was detected. At operation, left aberrant renal vessel was resected, and he has been free of pain. Case 2: A 65-year-old woman consulted our clinic because of abdominal pain and fever, who occasionally had the same episode. The existence and disappearance of the right hydronephrosis could be observed by emergency ultrasonography and following ultrasonic study, and the stenosis of the right lower ureter caused of cystitis cystica and glandularis was pointed out by retrograde ureterography. Diuresis ultrasonography by furosemide was performed to evaluate urinary tract stricture. In case 1, an incomplete obstruction pattern was obtained after operation, and in case 2, a complete obstruction pattern was shown. The emergency ultrasonography and diuresis ultrasonography were useful for the diagnosis and observation of intermittent hydronephrosis.
Aged↗
[A case of testicular tumor presenting as acute scrotum].
A case of teratoma of the testis presenting as sudden spontaneous hemorrhage without previous injury is described. A 25-year-old male was admitted with right scrotal pain and swelling. Though acute epididymitis or testicular torsion could not be neglected on physical examination, tumor-like echogram was obtained. High orchiectomy was performed subsequently. Macroscopically, testicular tumor with subcapsular hematoma was evident. Histopathological diagnosis was mature teratoma (pT1, No, Mo). The patient, after combined chemotherapy including cisplatin, vinblastine and peplomycin, is alive well without metastases for 15 months after operation.
Acute Disease↗
[Intrathecal clonidine--how does it work in spinal fentanyl analgesia in rats?].
The effects of intrathecal clonidine on spinal fentanyl analgesia were studied by the hot-plate test (52.0 degrees C) in rats. Clonidine (5 micrograms) and/or fentanyl (5 micrograms) were administered alone or combined in volume of 10 microliters through a chronically-implanted polyethylene catheter (PE-10) whose tip was near the lumbar enlargement of the spinal cord. Injections were done repeatedly every two or three days to determine the time course of thermal analgesia. Results were as follows; 1) Intrathecal clonidine (n = 5) produced no thermal analgesia. 2) Intrathecal fentanyl (n = 10) produced a profound thermal analgesia which was attenuated markedly by the repeated injections in six rats before the 9th injection. 3) Two out of six fentanyl tolerated rats responded with remarkable increases in thermal thresholds following the intrathecal clonidine with fentanyl. 4) Rats which were administered with both clonidine and fentanyl from the 1st injection (n = 9) responded with a extended prolongation of the escape latency, compared with the rats which received fentanyl only. In this group, the tolerance developed in only three animals by the 9th injection. In conclusion, combined intrathecal administration of clonidine with fentanyl potentiated the analgesic effect of fentanyl and then definitely suppressed the tolerance formation even if a small dose of clonidine which produces no analgesic effect was used. These results suggest that intrathecal or epidural administration of clonidine with narcotics might be useful in managing intractable pain.
Adaptation, Physiological↗
[Experimental study on the optimal size of the tricuspid valve annular area on annuloplasty].
The optimal size of tricuspid valve annular area (TVAA) by annuloplasty for tricuspid regurgitation remains controversial. Recently, we developed a new measuring system which permits to do real-time measurement of tricuspid valve annular area in anesthetized dogs. Using this system, we studied the optimal size of TVAA by annuloplasty. After the right atrial incision, a metal thread which functions as a sense loop of the electromagnetic fields was stitched along the tricuspid valve annulus (visible juncture of the valve leaflets and the cardiac wall). The drive coil assembly was placed perpendicular to the extension of the long axis of the heart and was directed toward the tricuspid valve region. During control conditions, the maximum TVAA appeared at the onset of ventricular systole. The minimum TVAA appeared during the early ventricular diastolic phase which included the ventricular isovolumic relaxation phase. The maximum TVAA varied in five dogs between 2.2 cm2 and 3.1 cm2, the minimum TVAA also varied between 1.8 cm2 and 2.5 cm2: During regular sinus rhythm, a decrease of TVAA during one cardiac cycle ranged between 11.9% and 22.4% of the maximum size. When TVAA was not decreased by annuloplasty to the minimum area which was observed during cardiac cycle in the control state, the cardiac output and the right atrial pressure remained unchanged, because the ventricular filling was not obstructed. On the other hand, when TVAA was decreased smaller than this minimum area, the cardiac output decreased and the right atrial pressure rose.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
[An experimental study of the use of fresh aortic valve homograft for the usage of the vena caval valve. Part 1. The evaluation of hemodynamics and cineangiographic study].
The purpose of this study is to develop a vena caval valve using the fresh aortic valve homograft. A preliminary study was performed in six dogs by interposing a cryopreserved aortic valve homograft with sinus Valsalva into SVC. After making the tricuspid regurgitation, the aortic valve homograft was closed by the regurgitant flow in the systolic phase and opened by the venous return in the diastolic phase. The preliminary study showed that the cryopreserved aortic valve homograft with sinus Valsalva was useful as a vena caval valve immediately after the implantation. Fresh aortic valve homografts were implanted in 11 dogs in the same manner. Eighteen pressure studies and cine-angiographies were performed in six dogs on 8 to 165 days after the implantation. Pressure studies showed minimal/small pressure gradients across the implanted homografts. However, cineangiography revealed appearance of regurgitation through the implanted homograft three months later. Thromboembolism was not happened in all dogs at all. Therefore, we concluded that the fresh aortic homograft with sinus Valsalva might be clinically feasible for use as a vena caval valve.
Animals↗