Thyroxine lowers the seizure threshold in experimental animals and humans. We report juvenile myoclonic epilepsy (JME) in two female patients with Graves' disease who had exophthalmos at age 11 (patient 1) and age 12 years (patient 2) but remained untreated until onset of seizures at ages 15 and 13 years, respectively. Seizures were not controlled well despite administration of antiepileptic drugs (AEDs) during the periods of excess serum thyroid hormones in Graves disease. When the serum levels of T3 were reduced to < 220 ng/dl with antithyroid drug treatment, both clinical seizures and paroxysmal EEG abnormalities disappeared despite discontinuation of AEDs and sleep deprivation. JME was noted only during periods of excess thyroid hormone and low compliance with antithyroid drug treatment. The excessively high level of thyroid hormones may have been a factor in precipitating the onset of JME.

Adolescent↗

PubMedDate not supplied

Video-polygraphic analysis of myoclonic seizures in juvenile myoclonic epilepsy.

We studied myoclonic seizures (MS) in 5 patients with juvenile myoclonic epilepsy (JME) using video polygraphic recordings to investigate the clinical characteristics of MS in this epileptic syndrome. The total number of MS analyzed was 302 (range 27-125, mean 60) seizures per patient. MS occurred either singly or repetitively (37 vs. 63%) and corresponded to generalized bilaterally synchronous single or multispike-and-wave complexes at 3-5 Hz. Video analysis of the myoclonic jerks demonstrated that either distal or proximal muscle involvement predominated. In the former, there was mild bilateral flexion and some external rotation of the forearms. In the latter, flexion of both arms at the elbow, flexion and abduction of the thighs, and extension of the back was observed. Asymmetry of MS was noted in 4 of 5 patients. Facial involvement of MS occurred infrequently in 2 patients. When the patients kept both arms outstretched, the arms dropped or there was sudden interruption of ongoing electromyographic (EMG) potentials immediately after myoclonic jerks (postmyoclonic inhibition) in all patients. One should inquire about these clinical characteristics of MS in JME when taking a thorough history in patients with primary generalized tonic-clonic seizures (GTC).

Adolescent↗

PubMedDate not supplied

[Sudden death in childhood bronchial asthma: report of one case].

Sudden death from childhood bronchial asthma is very rare in Taiwan. This is a case report of an eight-year-old boy who had been a victim of bronchial asthma since age five. He attained school regularly. Two days before death, he suffered from dyspnea, but the symptoms were relieved by oral drugs of beta 2-agonist and aminophylline. The drugs usually administered when he had attacks. Unfortunately he jumped and fell when he watched TV with his family at about 5 o'clock in the afternoon. He was cyanotic with apnea. He expired in spite of cardiopulmonary resuscitation for three hours in our hospital.

Asthma↗

PubMedDate not supplied

[Pulmonary plasma cell granuloma: report of one case].

Pulmonary plasma cell granuloma is very rare in pediatric field. Most of them are asymptomatic, and are usually found to have lung tumor accidentally by chest X-ray examination. The granuloma is characterized by the proliferation of plasma cells along with other mesenchymal elements. We report a case of 10-year-old boy who suffered from dry cough, pale face and body weight loss for a long time. Chest X-ray and CT scan revealed a lung tumor which was proved to be plasma cell granuloma after wedge biopsy. He was regularly followed up at OPD with stationary status. He may receive surgical resection in future.

Child↗