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Biomedical subjects

Y H Hsu

Publications and source records attributed to Y H Hsu.

At least 91 records · Page 5Linked to original sources
PubMed1989

Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. II. Physico-chemical properties and structure determination.

The structure of a new antitumor antibiotic, myrocin C, from a strain of Myrothecium verrucaria was characterized as a pentacyclic pimarane diterpene composed of a gamma-lactol group and a unique cyclopropane ring on the basis of its physico-chemical properties and spectroscopic data as well as a single-crystal X-ray diffraction analysis of its monoacetyl derivative.

Antibiotics, Antineoplastic↗
PubMed1984

Immunogold for detection of antigen on nitrocellulose paper.

The application of immunogold for the detection of antigen-antibody complexes on nitrocellulose paper is described. Tobacco mosaic virus (TMV) protein, either purified or in leaf extract, was bound to the nitrocellulose paper and then exposed to rabbit anti-TMV serum. The antigen-antibody complexes were detected by gold-labeled goat anti-rabbit immunoglobulin G. The gold-labeled antibody is directly visible because of its pink color. This method can detect 1-5 pg of TMV protein, either in purified form or in the unpurified plant extract, with high specificity.

Animals↗
PubMed1982

Carcinoma of the pancreas: diagnosis and treatment.

We made a retrospective analysis of the hospital record of 65 cases of carcinoma of the pancreas occurring over a 16-year period at Bayley Seton Hospital, Staten Island, New York. The male sex predominated; the average age was 62.5 years. About 72% of the tumors were located at the head of the pancreas. The patients were divided into four groups: (1) those treated by pancreatoduodenectomy (Whipple resection) (14 cases), (2) those treated by bypass operations (21 cases), (3) those managed by exploration for biopsy only (12 cases), and (4) those in whom the carcinoma of the pancreas was found only at autopsy (18 cases). The operative mortality in the Whipple group was 7%; in the bypass group, 14%; and in the exploratory biopsy group, 36%. The mean survival in the Whipple group was 27.2 months with one survival more than ten years; in the bypass group, 6.5 months; and in the biopsy group, 2.6 months. Autopsy studies showed a high rate of regional and distant node metastasis, as well as nonnodal metastasis to other organs. Most of the patients died of carcinomatosis. The operative technics and the surgical literature are discussed.

Adenocarcinoma↗
PubMed1978

Extracardiac rhabdomyoma: a rare entity.

Extracardiac rhabdomyomas are rare benign lesions of striated muscle origin. A review of the world literature revealed about 27 acceptable cases of benign, adult-type rhabdomyoma with a distinct male predominance. In most of the reported cases, the tumor was located in the head and neck region, usually submucosal or deeper. The case reported here is unusual because the tumor was subcutaneously located in the neck. The tumor was fairly well circumscribed, multilobulated, and easily shelled out. Light microscopy showed large round to elongated cells with granular, highly eosinophilic cytoplasm, often with peripheral vacuolation. Cross striations were infrequent. The nuclei were often peripheral and had prominent nucleoli. Electron microscopic studies confirmed the tumor's myogenic origin. Myofibrils with Z band material, abundant mitochondria, and glycogen particles were observed.

Diagnosis, Differential↗
PubMedDate not supplied

Pyogenic granuloma--an uncommon complication of nasal packing.

Nasal packing is a very common procedure in the otolaryngologic service for nasal bleeding and postoperative hemostasis. However, a pyogenic granuloma complicated from nasal packing has not been reported in the literature. A 50-year-old man underwent nasal packing by use of vaseline gauze due to nasal bleeding. Two weeks later, a dark brown nasal tumor was found in his nasal cavity. He underwent partial turbinectomy for removal of the tumor. The pathology demonstrated a pyogenic granuloma. It is the first case of a confirmed pyogenic granuloma complicated from nasal packing in the literature. To prevent complications and decrease the discomfort, we strongly recommend the use of inflatable balloons or nontraumatic materials for nasal packing.

Epistaxis↗
PubMedDate not supplied

Extreme hypergastrinemia caused by atrophic gastritis and Helicobacter pylori infection--a case report.

We present a case with extremely high serum gastrin induced by atrophic gastritis and Helicobacter pylori infection. The patient, a 95-year-old male, was diagnosed with idiopathic chronic diarrhea. During diagnostic work-up, his fasting serum gastrin was up to 2078 pg/mL. The secretin test was negative for gastrinoma. Octreotide scan showed no suspicious lesion except for diffuse faint uptake over the gastric antrum on the 48-hour-delay film. Gastric acidity test revealed achlorhydria. On histology examination, atrophic gastritis with Helicobacter pylori infection was found in the gastric body, but the antral mucus was normal with a slight increase in gastrin-secreting cells. To our knowledge, such extremely high serum gastrin induced by atrophic gastritis and Helicobacter pylori infection has never been reported before.

Aged↗
PubMedDate not supplied

Idiopathic dilated cardiomyopathy complicated with brain embolism: report of one case.

Idiopathic dilated cardiomyopathy complicated with brain cardioembolism is rarely documented by both 2-dimensional echocardiography and cranial computed tomography in pediatric patients. A 2-year-old girl developed hemiparalysis 15 months after diagnosis of idiopathic dilated cardiomyopathy. The 2-dimensional echocardiograms of left ventricular thrombi, computed tomographic findings of brain embolism, clinical course, treatment and outcome are presented. Previous reports of idiopathic dilated cardiomyopathy in children are reviewed.

Cardiomyopathy, Dilated↗
PubMedDate not supplied

[Wilson disease presenting as fulminant hepatic failure, acute hemolytic anemia and renal failure: report of one case].

Wilson disease presenting as fulminant hepatic failure, severe hemolysis and renal failure is rare in the literature. A ten-year-old boy--complaining of abdominal pain, jaundice, tea-colored urine, and anemia was admitted to this hospital; examination showed Kayser-Fleischer rings, anemia associated with hemolysis, mildly elevated serum transaminases, extremely elevated bilirubin levels, low serum ceruloplasmin level, slightly elevated serum copper, excessive 24-hour urine copper excretion, and severe renal function insufficiencies. Under the impression of Wilson disease with fulminant hepatic failure, the patient was treated by oral D-penicillamine 1 gm per day, intravenous zinc sulphate (about 8 mg per day elemental zinc), and given other supportive treatment. Unfortunately, the patient died of hepatic failure complicated with septic shock 21 days after the onset of symptoms. Autopsy found liver copper content was 586.92 ug/gm dry weight and kidney copper content: 300.19 ug/gm dry weight, abnormally high as compared with normal tissue. A review of the literature led to conclusion that the best treatment for Wilson fulminant hepatic failure is liver transplantation.

Acute Disease↗
PubMedDate not supplied

A fatal case of viral pneumonia in a child infected with adenovirus type 3.

This report describes the clinical, roentgenologic, pathologic, and virologic findings in a 2 years and ten months old girl who died from a severe pneumonia. Initially, the patient presented with fever and cough for 2 days. Physically, the patient appeared lethargic, and breathing sounds revealed diffuse rales and wheezing. Hemogram showed mild leukocytosis and lymphocyte predominant. Chest X ray revealed diffuse interstitial infiltration of the right upper lung, left upper and left lower lung field. Bacteria infection was first impressed. Although treated with several antibiotics (ampicillin, cefuroxime, amikacin, penicillin, cephazolin, imipenem and vancomycin) in three different hospitals, the patient's condition went downhill and the patient died 2 weeks later. Finally, adenoviurs type 3 was isolated from sputum specimen taken before death and necropsy lung tissue. The lung pathology showed diffuse necrotizing inflammation with fibrinopurulent exudate, and eosinophilic intranuclear inclusion bodies were also noted in the alveolar cells. These data proved the diagnosis of adenovirus pneumonia. This case adds to the evidence that adenovirus type 3 infection during childhood may cause fatal disease.

Adenovirus Infections, Human↗