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Biomedical subjects

Y Gutierrez

Publications and source records attributed to Y Gutierrez.

31 records · Page 2Linked to original sources

Human ectopic fascioliasis in the cecum.

A case of ectopic human Fasciola spp. infection in the cecal wall is reported. The patient, a 27-year-old Korean woman, resident in Seoul, Korea, presented with nausea, vomiting, and epigastric tenderness. One week later a palpable mass was discovered in the right iliac fossa. A clinical diagnosis of a carcinoma of the colon was made and the patient underwent a cecal resection. The mass proved to be an inflammatory reaction containing numerous tracts made by the migrating fluke, Fasciola sp.

Adult↗

Breast nodule produced by Dirofilaria tenuis.

A case of Dirofilaria tenuis presenting as a breast nodule is reported in a patient who traveled to the southeast United States 6 months before the nodule was noted. It illustrates an unusual diagnostic problem, especially since it presented in a nonendemic area. The morphological criteria for diagnosis of D. tenuis in tissue sections are noted.

Animals↗

Pathologic changes in murine leishmaniasis (Leishmania donovani) with special reference to the dynamics of granuloma formation in the liver.

The histopathologic changes in liver, spleen, and bone marrow of BALB/c mice infected for 6 months with Leishmania donovani are described. Granulomas were the most important histologic lesions found; and the dynamics of their formation, collagen deposition, and resolution in the liver were studied. The number of hepatic granulomas increased until the eighth week and then decreased steadily. In contrast to the liver granulomas, those of spleen and bone marrow do not mature or show collagen deposition. Actual granuloma counts in the liver support the idea that mature granulomas revert to poorly formed ones and finally resolve without scarring. BALB/c mice are suitable for the study of the dynamics of granuloma formation and resolution and the survival of L donovani in an in vivo system. The relevance of these changes to the pathology of L donovani infection in man are discussed.

Animals↗

Latin American nursing students in the United States.

The Latino students confront a unique set of difficulties and patterns of adjustment in the majority culture and the educational experiences in the United States. Careful consideration must be given not only to the general characteristics of this group, but also to the individual's history of immigration, socioeconomic status, educational experiences and background. Multicultural education for the international nursing students can benefit all students, but it should not gloss over conflicts of values and beliefs. It must honestly deal with differences and similarities. It must be based on experience, not on stereotypes of root cultures or ethnic characteristics. In addition to addressing the cognitive affect and skill needs of all students, the multicultural education must address the special needs of minorities. Anglo students or majority-group students need realistic opportunities for experience and interaction with minority students and minority-faculty. Every group has something to teach the other. Faculty advisors and majority students should be encouraged to acquaint themselves with the need to establish rapport with the Latino student. There is also a need to develop in the classroom an atmosphere that enhances the learning experiences. The learning experiences should be so designed that all students and school personnel can intellectually, emotionally and socially participate on equal terms in a culturally diverse society.

Acculturation↗

Brugia infection in Northern Ohio.

A new case of infection with Brugia sp. is recorded from Northern Ohio, increasing the geographical range of this zoonosis, known previously in New England, New York and New Jersey. The patient, a 53-year-old man, had a 7-year history of malignant fibrous histiocytoma of the spermatic cord, for which he received intense chemo- and radiotherapy. The worm found was alive at the time of fixation, allowing a description of the parasite in cross sections.

Animals↗

Living retinal nematode (filarial-like) destroyed with photocoagulation.

A motile worm creating tracks upon the pigment epithelium of the retina was observed in each of two patients. The fundus findings resembled pseudoretinitis pigmentosa. Unilateral macular degeneration resulted in one patient. The worm was a nematode, probably a filaria. This report represents the third and fourth intraocular filariae found in the United States. To our knowledge, it is the first report of living, intraretinal filarial-like worms destroyed by photocoagulation.

Adolescent↗

Experimental infection of Aotus monkeys with Plasmodium falciparum Light and electron microscopic changes.

Six splenectomized Aotus owl monkeys were infected with P. falciparum. The animals were sacrificed when they became moribund and tissues were faken for light and electron microscopic studies. Electron microscopy revealed marked structural changes in both the liver and the heart. In the liver there was glycogen depletion, lipid droplet infiltration mitochondrial disorganization with reduction in numbers and alterations of the microvilli in the sinusoidal pole and the bile canaliculi. In the heart, there was lipid droplet infiltration and focal disorganization of the myofibrils around the intercalated disc. There was focal mitochondrial disorganization and mitochondrial concentration around the muscle lesion. The ultrastructural changes in liver and heart were similar to those described in animals dying of shock, of at least two hours duration, in different experimental models. Ultrastructural lesions found in other organs were less marked. In the kidneys there was mainly a moderate lipid infiltration of the tubular epithelium. This change is probably the early precursor of that seen at four hours in animals dying in experimental shock. The above changes are discussed in light of the known pathophysiology of both experimental infections in animals and natural human malarial infections.

Animals↗

Reye's syndrome and cerebellar intracytoplasmic inclusion bodies.

A patient with Reye syndrome had intracytoplasmic inclusion bodies in Purkinje cells. Electron microscopical examination demonstrated the inclusions to contain internal particles, but these were not identifiable as known virions. Results of viral studies were normal.

Basal Ganglia↗

Agenesis of arachnoid granulations and its relationship to communicating hydrocephalus.

The authors discuss reabsorption of cerebrospinal fluid in relation to the post-mortem findings in two children, one with total agenesis of the Pacchionian system accompanied by hydrocephalus, and the other with a subtotal agenesis and no hydrocephalus. Case 1 is the only known documented case of total agenesis of the Pacchionian system and gives credence to the idea that an impaired reabsorption of cerebrospinal fluid at the level of the Pacchionian system is a cause of hydrocephalus. The patient in Case 2 showed only two small areas of arachnoid granulations containing a few flattened, microscopic villi of normal cellularity.

Arachnoid↗

Modeling diamagnetic and magnetooptic properties of organic compounds with the TOSS-MODE approach.

The topological substructural molecular design (TOSS-MODE) approach is used to describe the diamagnetic susceptibility of organic compounds. Two data sets composed of 233 aliphatic and 85 aromatic compounds were studied for which good linear correlations were found. The contributions of many different structural fragments and atomic groups were computed by the current approach. The predictive ability of the models developed was tested by using external prediction sets of compounds of different classes than those used in training. A quantitative model based on the current approach was developed to compute the diamagnetic susceptibility exaltation of aromatic compounds, which is exemplified by the study of polycyclic aromatic hydrocarbons. The rotatory power of organic compounds in a magnetic field was also described by the TOSS-MODE approach. Good linear correlations were obtained for this property in aliphatic and aromatic compounds. The predictive abilities of the models found were tested by external prediction sets for which good correlations between calculated and experimental values are found.

Journal Article↗

Recruitment and retention of healthy minority women into community-based longitudinal research.

This report examines the impact of individualized, population-based recruitment and retention approaches on the development of a subject pool, enrollment, and retention at 12 months of healthy, community-based women in three ethnic groups: African Americans, non-Hispanic European Americans, and Mexicans/Central Americans. Of 722 women contacted and screened, 346 (48%) were eligible and consented to participate. Attrition at 12 months was low (10%) compared with other published reports. The largest group of potential subjects was identified through broadcast media approaches, but this method produced the highest number of ineligible women and highest rate of attrition. Printed matter produced the next largest group of potential subjects, but ineligibility was high (53%). Face-to-face interactions enrolled the highest proportion of eligible women (84%) and lowest overall attrition (7%). Direct referral yielded fairly efficient enrollments (57%) and average attrition. Multiple approaches for recruitment can produce a diverse sample of healthy, community-based women. Face-to-face recruitment results in the highest yield of participants with the lowest attribution but is presumed to require more resources.

Adult↗

Subclinical vitamin A deficiency: a potentially unrecognized problem in the United States.

Vitamin A deficiency in its subclinical form is a world health problem in young children. The problem is probably under recognized in the United States and other developed countries who do not normally consider their citizens to be malnourished. Lack of a simple screening test to measure subclinical deficiency adds to this problem. Consequently, focused dietary assessment of vitamin A intake by a Food Frequency Questionnaire (FFQ) is a necessary component of health care maintenance, especially for toddlers and preschool age children. Dietary counseling and vitamin supplementation for high risk children is a necessary health promotion intervention.

Adolescent↗