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Biomedical subjects

Y G Leclerc

Publications and source records attributed to Y G Leclerc.

2 recordsLinked to original sources

Shape from shadows.

The colors, textures, and shapes of shadows are physically constrained in several ways in natural scenes. The visual system appears to ignore these constraints, however, and to accept many patterns as shadows even though they could not occur naturally. In the stimuli that we have studied, the only requirements for the perception of depth due to shadows were that shadow regions be darker than the surrounding, nonshadow regions and that there be consistent contrast polarity along the shadow border. Three-dimensional shape due to shadows was perceived when shadow areas were filled with colors or textures that could not occur in natural scenes, when shadow and nonshadow regions had textures that moved in different directions, or when they were presented on different depth planes. The results suggest that the interpretation of shadows begins with the identification of acceptable shadow borders by a cooperative process that requires consistent contrast polarity across a range of scales at each point along the border. Finally, we discuss how the identification of a shadow region can help the visual system to patch together areas that are separated by shadow boundaries, to identify directions of surface curvature, and to select a preferred three-dimensional interpretation while rejecting others.

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Osteoclast enlargement in endstage renal disease.

In normal subjects and patients with endstage renal disease, osteoclast cell volumes were constructed using serial 2-micron thick plastic embedded sections from iliac crest bone biopsy specimens. Four cells randomly selected from each of the subjects were analyzed to give both the cell volume from the cumulative areas and thickness of each cell slice and also the cell axes taking the vector along the bone face as width or Y, thickness from the bone surface as breadth or X and vertical dimension length or Z. The mean cell volume was 6,230 microns3 in the control subjects and was significantly larger being 11,730 microns3 and 13,680 microns3 in the two patient groups. The cells showed polarity with the largest axes, Y and Z, being those in apposition to the bone surface. Howship's lacunae were enlarged in the patients and the cross-sectional area of an individual lacuna corresponded to the area of the contiguous osteoclast, r = 0.62, P less than 0.001. All patients had secondary hyperparathyroidism and osteoclast numbers were increased. There was no correlation between osteoclast size and duration of renal failure, previous vitamin D intake, or aluminum exposure. It is suggested that in ESRD, osteoclasts undergo both an increase in number and size and that these cells, being larger, remove more bone than the smaller cells in normal subjects.

Adult