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Biomedical subjects

Y Fukumoto

Publications and source records attributed to Y Fukumoto.

At least 163 records · Page 9Linked to original sources
PubMed1982

Clinicopathological studies of the Dubin-Johnson syndrome complicated with chronic hepatitis.

Eleven patients with Dubin-Johnson syndrome (DJS) were studied clinicopathologically. In three patients with DJS, concomitant chronic hepatitis was observed. They showed long-standing jaundice with the symptoms of general fatigue and anorexia. Laboratory tests revealed mild hypertransaminasemia, elevated serum bilirubin (over 5.0 mg/dl) and a high level of serum Bromsulphalein (BSP) retention at 45 min (above 18%). Two patients complicated with chronic hepatitis showed a rather slow secondary rise in the BSP excretion curve in comparison with the patients who had no complication. One patient accompanied with the most severe fibrosis showed no secondary rise in the BSP excretion curve. After the treatment of the patient with phenobarbital, however, a secondary rise in the BSP excretion curve appeared and the serum BSP level was also significantly decreased at all points on the BSP excretion curve. Histological examination of the liver revealed the decreased number of the Dubin-Johnson pigments in the patients complicated with chronic hepatitis. Laparoscopically, a patient with a chronic aggressive hepatitis showed a dark gray decololization of the liver surface and another patient with a chronic aggressive hepatitis showed a black color of the liver surface with partial nodule formation.

Adult↗
PubMed1982

Comparison of diurnal serum insulin levels during short term treatments with sulfonylurea and with insulin in non-insulin dependent diabetes.

Nine non-insulin dependent type diabetic patients were hospitalized and place on the standard diabetic diet throughout this study period. (25 cal/kg ideal weight/day). After three days of diet therapy alone, 5 mg of glibenclamide was given orally for three days, followed by an interval of four days without medication. 16 units of lente insulin was then administered subcutaneously for three days. The diurnal levels of plasma glucose (PG) and serum immunoreactive insulin (IRI) were determined on the third day of each treatment, and the integrated areas below the curves of the diurnal profile of PG and IRI were compared. The mean fasting PG level before treatment was 200 +/- 21 mg% (mean +/- SE). The initial PG area during diet therapy alone, (4,245 +/- 669 mg . h/dl) decreased significantly to similar levels both by glibenclamide (3, 317 +/- 384 mg . h/dl, P less than 0.05) and by lente insulin (3,177 +/- 552 mg . h/dl, P less than 0.01). The IRI area increased from 187 +/- 24 micromicron . h/ml during diet therapy alone to 296 +/- 65 micromicron . h/ml by glibenclamide (P less than 0.01), and to 267 +/- 43 micromicron . h/ml by lente insulin (P less than 0.05). There was no significant difference between glibenclamide and lente insulin treatments either in PG area or IRI area. These finding suggest that the hypoglycemic effect of glibenclamide treatment in the short term is mainly, if not entirely, due to augmented endogenous insulin secretion.

Adult↗
PubMed1982

Calcium release from membrane-bound calcium pool induced by ACTH.

We examined the effect of ACTH on the binding of Ca2+ to the plasma membrane of rat fat cells. Synthetic I-24 ACTH reduced the binding of 45Ca to the fat cell membrane dose-dependently. Whereas verapamil significantly increased binding, Ca ionophore A23187 significantly reduced it. These results suggest that ACTH induced the promoted release of Ca2+ from the plasma membrane-bound Ca pool into cytosol. ACTH-induced binding of 45Ca to the fat cell membrane occurred at at least two binding sites, i.e., high and low affinity binding sites. Epinephrine did not significantly influence 45Ca binding, showing an evident difference in the Ca2+ dependence of the lipolytic actions of ACTH and epinephrine.

Adipose Tissue↗
PubMed1981

Increase of T cells in the liver during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.

The localization of thymus-derived lymphocytes (T cells) was investigated in rat liver by the immunofluorescence method during hepatocarcinogenesis with N-2-fluorenylacetamide. In the early stage of carcinogenesis, the number of T cells never increased significantly in livers in which hyperplastic liver nodules (population I) were seen. On the other hand, in the late stage of carcinogenesis, T cells extensively invaded hyperplastic nodules (population II) as well as hepatomas. According to the concept of cell-mediated immunity, hyperplastic nodules in the late stage might have a neoantigen(s) which evokes the response of T cells. Therefore, it may be concluded that populations I and II are biologically distinct lesions in spite of their histological identity.

2-Acetylaminofluorene↗
PubMed1980

Complication of laparoscopy in Japan.

Trends of examinees and complications of laparoscopy were examined by a questionaire sent to all representative institutions in Japan. As a conclusion, the rate of complication by this examination was 10 times higher, while its mortality was 25 times higher, as compared with gastroenterological endoscopic examination. This article may indicate the present status of laparoscopy in Japan.

Adult↗
PubMed1980

Peritoneoscopic findings and liver function in chronic liver disease.

In 100 cases with chronic liver disease, peritoneoscopy and liver biopsy were performed, and the association between peritoneoscopic findings and liver function was studied. With respect to liver function, a series of tests which seem to indicate residual liver function were selected as follows; dye excretion, serum levels of albumin and cholinesterase, and subfractions of serum proteins. In evaluating the periotoneoscopic view, new criteria for the classification of liver surface findings are proposed. All cases were divided into 5 types in accordance with these criteria. Analysis of the correlation between peritoneoscopic findings and liver function showed that the degree of liver dysfunction was clearly indicated by liver surface alterations. As a result, the residual liver function may be determined quite well by using this classification.

Biopsy↗
PubMed1980

Clinical implications of alpha-fetoprotein in liver cirrhosis: five-year follow-up study.

The level of alpha-fetoprotein (AFP) was estimated by radioimmunoassay or passive hemagglutination method in a series of 159 patients with liver cirrhosis, and the incidence of serum hepatitis B antigen, histopathologic features of the liver, incidence of development of hepatocellular carcinoma (HCC) and mortality in AFP-positive cases were studied. Approximately 40 per cent of the patients had an AFP level higher than 20 ng/per ml, and all the elevations of AFP over 100 ng per ml were transient. In contrast, patients who developed HCC during the course of the disease always exhibited an increasing value of AFP. The seropositivity for AFP was significantly related to the presence of serum hepatitis B surface antigen and also to liver cell dysplasia as well as to thickening of the liver cell plates. As compared with a group of AFP-negative cases, the AFP-positive group showed a higher incidence of development of HCC and poorer prognosis over a five-year follow-up period. The data obtained suggested that increased AFP-production in patients with liver cirrhosis might reflect, largely an abnormal or altered liver cell regeneration, probably associated with hepatitis B virus, and that patients with transiently elevated AFP values might be at greater risk for the development of HCC.

Carcinoma, Hepatocellular↗
PubMed1980

Studies of alpha-napthylisothiocyanate-induced hepatic disturbance.

In order to clarify the mechanism of alpha-naphthylisothiocyanate (ANIT) induced cholestasis in rats, a few hepatic changes seen after administration of ANIT 80 mg/kg body weight were examined in relation to time. To clarify changes in the bile production system and bile flow, the concentrations of bile acid and bicarbonate, as well as of sodium in the bile, were measured after infusion of secretin and taurocholic acid. The canalicular bile flow was estimated by measuring the biliary clearance of erythritol-C14. To assess hepatocellular injury, the levels of cytochrome P-450 in the microsome of hepatocytes and protein synthesis in the liver were estimated. It seems that ANIT is activated in the drug metabolising system through cytochrome P-450 in the liver, and significant changes are produced in both the bile acid metabolism and its transport system. Bile acid-independent bile flow in the canaliculus was inhibited, too. Hence, both the bile ductules and the bile ducts are functionally and histologically disturbed.

1-Naphthylisothiocyanate↗