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Biomedical subjects

Y Fujiki

Publications and source records attributed to Y Fujiki.

At least 181 records · Page 10Linked to original sources
PubMed1979

Clinical and radiographic study of dens invaginatus.

After a determination of the frequency of dens invaginatus by means of radiographic observations, various problems of its identification are discussed. The 188 teeth showing a distinct loop-shaped invagination apically on the radiograph were studied for the presence or absence of caries and periapical lesions. It was demonstrated that periapical lesions caused by caries are mostly due to interproximal caries and that the frequency of periapical lesions caused by caries in the dens invaginatus area was less than previously reported. Comments are made on the dens invaginatus cases having periapical lesions without caries and the parameters for future studies.

Adult↗
PubMed1978

Isolation and amino acid sequence of the alpha-subunit of follicle-stimulating hormone from equine pituitary glands.

Six hundred milligrams of follicle-stimulating hormone (FSH), containing 110 NIH-FSH-S1 units/mg, was isolated from 9 kg of equine pituitary glands. The equine FSH was dissociated into alpha- and beta-subunits. A tentative amino acid sequence of the alpha-subunit was determined. The alpha-subunit contained 82 amino acids. The equine FSH-alpha is shorter by 10 to 14 amino acids at the NH2 terminus and has several substitutions at several positions as compared with human FSH-alpha and bovine thyroid-stimulating hormone-alpha. At the intraspecies level, the alpha-subunits of human FSH, human luteinizing hormone, and human chorionic gonadotropin are similar, whereas at the interspecies level there are differences among the alpha-subunits of FSH, luteinizing hormone, and thyroid-stimulating hormone.

Amino Acid Sequence↗
PubMed1978

Amino acid sequence of the beta-subunit of the follicle-stimulating hormone from equine pituitary glands.

A tentative amino acid sequence of the beta-subunit of equine follicle-stimulating hormone (FSH) was derived from the sequences of tryptic, thermolytic as well as peptic, subtilisin, and chymotryptic peptides. Equine FSH-beta is analogous to human FSH-beta except six amino acid substitutions at positions 12, 16, 21, 62, 108, and 114. The amino acid sequence suggests that the hormone-specific beta-subunits of FSH are similar at the interspecies level, whereas the amino acid sequences of the hormone nonspecific alpha-subunits show variations.

Amino Acid Sequence↗
PubMed1977

Radiographic observations of pyknodysostosis. Report of a case.

A case of pyknodysostosis in a 32-year-old woman has been reported. The patient presented typical skeletal changes, separated cranial sutures, open fontanelles, partial aplasia of the terminal phalanges of the fingers and toes, and brachyphalanges. The oral findings included lesions resembling periapical cementoma, hypoplasia of the maxilla and mandible, crowding of teeth, and a median raphe.

Abnormalities, Multiple↗
PubMed1965

[Thyroiditis].

Explore the source record for details and available documents.

Humans↗
PubMedDate not supplied

Prenatal sonographic diagnosis of Beckwith-Wiedemann syndrome in association with a single umbilical artery.

Beckwith-Wiedemann syndrome is an inherited disorder most commonly characterized by prenatal or postnatal overgrowth, macroglossia, omphalocele, unusual earlobe creases, and increased risk of neoplasia. Several reported cases of this syndrome have been prenatally diagnosed, but no report has described the occurrence of this syndrome in association with a single umbilical artery. We report a case in which prenatal sonographic examination demonstrated fetal overgrowth, macroglossia, and omphalocele together with a single umbilical artery; our prenatal diagnosis of Beckwith-Wiedemann syndrome was confirmed after birth of the infant. The possibility of this syndrome should be considered when performing a detailed sonographic examination of a fetus with a single umbilical artery.

Adult↗
PubMedDate not supplied

Dose-response relationship of cadmium embryotoxicity in cultured mouse embryos.

Mouse embryos were exposed in vitro to 1.2 to 2.2 microM cadmium, and effects on embryotoxicity were examined after 39 h of culture. Teratogenic responses similar to in vivo were obtained at 1.2 to 2.2 microM with concomitant reduction in embryonic protein, while embryo deaths were increased from 13.8 to 93.3% at 2.0 to 2.2 microM. The response data of both teratogenicity and growth parameters, including embryonic protein, head length, crown-rump length, somite number, and protein and diameter of yolk sac, were acceptably fitted to a linear log-probit regression. These results suggest that (a) In chronic exposure conditions, the concentration of cadmium is a critical parameter in the manifestation of teratogenic potential, (b) as an estimation of interference in the growth of embryos, embryonic protein is one of the most sensitive endpoints while somite number is an insensitive criterion, and (c) a linear log-probit regression is applicable to the analyses of embryotoxicity data, including growth parameters in whole-embryo culture systems.

Abnormalities, Drug-Induced↗