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Biomedical subjects

Y Finkelstein

Publications and source records attributed to Y Finkelstein.

At least 127 records · Page 7Linked to original sources
PubMed1989

Postirradiation hearing loss.

Hearing loss due to irradiation of the head-and-neck region is a rarely reported complication of such a treatment. Although experimental work had been performed in laboratory animals as early as at the turn of the century, substantiated clinical data in large series are lacking. The few reports published are somewhat contradictory as to the incidence, time of onset, type and severity of the hearing loss. Although infrequently encountered, the possibility of radiation-induced hearing loss should be kept in mind. The pertinent literature is reviewed.

Animals↗
PubMed1989

Amyloid goiter.

A case of a 50-year-old patient suffering from secondary amyloidosis presenting with amyloid goiter is described. The diagnostic and therapeutic implications are reviewed.

Amyloidosis↗
PubMed1989

Radiological case of the month. Monostotic fibrous dysplasia of the temporal bone.

Computed tomographic scan demonstrating narrowing of the left external auditory canal caused by an expansile bone lesion of the temporal bone (curved arrow). The regional bone was characterized by a "ground-glass" appearance. A small cholesteatoma is located between the tympanic membrane and the bony lesion (black arrow).

Adolescent↗
PubMed1988

An objective method for evaluation of the patulous eustachian tube by using the middle ear analyzer.

Patulous eustachian tube is more common than is usually presumed. The symptoms of this condition can paradoxically simulate an obstruction of the eustachian tube. The characteristic eardrum movements synchronized with breathing can be overlooked or be absent altogether and, therefore, the diagnosis in many cases is missed. We suggest using the middle ear analyzer for diagnosis and objective evaluation of the patent eustachian tube by adjusting it as for acoustic reflex testing. Our method is more sensitive than the more common method of tympanometry. Information is supplied for the patient's evaluation before and after treatment.

Acoustic Impedance Tests↗
PubMed1988

Brain acetylcholinesterase after acute parathion poisoning: a comparative quantitative histochemical analysis post mortem.

The postmortem distribution of acetylcholinesterase (AChE) inhibition was studied in the brains of 2 victims of lethal parathion intoxication and 2 control brains matched for age and sex. AChE activity in discrete brain regions was studied by quantitative histochemistry of 40-micron-thick sagittal or coronal cryostat sections from the 4 brains. Inhibition of human brain AChE by parathion is regionally selective. The biggest decreases (60-85%) were observed in the cerebellum, some thalamic nuclei, and the cortex. Only a moderate decrease (10-30%) was observed in the substantia nigra and basal ganglia, and no effect was seen in white matter. Detailed knowledge of the brain regions affected by parathion poisoning may explain some of the clinical manifestations of organophosphate poisoning.

Acetylcholinesterase↗
PubMed1988

Astereognosis as a presenting symptom in cervical meningioma.

Three unusual cases with astereognosis caused by cervical meningioma are presented. Astereognosis of subcortical origin has been reported several times. According to these reports, the causative lesion was confined to the area extending between the lower brain stem and the fourth cervical vertebra, thus suggesting that a sensory centre for stereognosis could be confined within these well defined anatomical limits, and that therefore a lesion in this area could lead to astereognosis. It is assumed in this paper that the lesion involves the sensory system of the Nucleus Cervicalis Lateralis. Fibres from the spinothalamic tract, a specialized sensory pathway, ascend from the palms of the hands to this nucleus. From this nucleus arise fibres which decussate and reach the Ventral Posterolateral Nucleus of the thalamus. It is likely that a lesion of the nucleus itself or its related sensory tracts may cause astereognosis.

Aged↗
PubMed1988

CNS involvement in acute organophosphate poisoning: specific pattern of toxicity, clinical correlates and antidotal treatment.

The present review was designed to integrate both experimental and clinical data and to focus on the problems of management of severe cases of acute organophosphate poisoning, which always show CNS involvement. AChE activity, in discrete regions of the human brain, was studied by quantitative histochemistry of 40 mu thick sections. The regional effects of AChE inhibition by organophosphates was examined in a comparative study of the brains of two victims and two control brains, matched for age and sex. The pattern of AChE inhibition was regionally selective. The most significant decreases were observed in the neocerebellum, thalamic nuclei and the cortex. This specific distribution of AChE inhibition may be correlated with some of the clinical characteristics of acute organophosphate poisoning. The diagnostic value of blood AChE levels was examined in a personal series of 53 patients, who needed artificial ventilation, intensive care monitoring and antidotal treatment. The effects and side-effects of the antidotal treatment were reassessed. Recommended regimen of therapy was outlined, based upon experience in this series and in recent animal studies. The logical therapy would be and almost always in the co-administration of an anticholinergic drug (usually atropine) and an AChE reactivator (oximes) in order to rapidly obtain the most beneficial effect in the critically ill patient. Seizures that do not respond to the specific antidotal therapy, should be treated with I.V. benzodiazepines. Artificial respiration and supportive measures are essential for patient' survival. They enable the patient to gain the necessary time for sufficient recovery of AChE activity.

Acetylcholinesterase↗
PubMed1988

Brain acetylcholinesterase after parathion poisoning: a comparative quantitative histochemical analysis post-mortem.

The regional distribution of AChE inhibition by parathion in the human brain was examined in a comparative study of the brains of 2 victims of lethal parathion intoxication and 2 control brains matched for age and sex. AChE activity in discrete brain regions was studied by quantitative histochemistry of 40 microns-thick sagittal or coronal cryostat sections from the 4 brains. The inhibition of human brain AChE by parathion is regionally selective. The biggest decreases were observed in the cerebellum, some thalamic nuclei and cortex. Only a moderate decrease (10-30%) was observed in the substantia nigra and basal ganglia, while no effect at all was seen in white matter regions. Detailed knowledge of the brain regions affected by parathion poisoning may explain some of the clinical manifestations of organophosphate poisoning.

Acetylcholinesterase↗
PubMed1988

Scrofula revisited.

Mycobacterial cervical lymphadenitis, or scrofula, is a disease dating back thousands of years. In spite of modern treatment and public health measures, scrofula persists but is infrequently seen. Five patients with cervical tuberculous lymphadenitis as a sole presentation have been seen in our department in the last 10 years. The clinical presentation and current methods of diagnosis and treatment are described. A short historical review is given.

Adolescent↗
PubMed1988

Teratoma of the mastoid region in a newborn.

Teratomas are congenital tumours arising from pluripotent cells and usually consisting of tissue arising from all 3 embryonic germ layers. Teratomas are quite uncommon in head and neck sites and to date only 150 such cases have been reported. A rare case of teratoma of the mastoid region in a newborn is reported. The method of diagnosis and treatment are discussed and the literature is reviewed.

Female↗
PubMed1988

Serratia marcescens infected silk suture rejected by combined acupuncture, moxibustion and low-power laser therapy from the abdominal fascia.

Upper abdominal pains lasting 12 years after cholecystectomy, were improved in an 82-year-old woman following the rejection of indigestable silk surgical sutures induced by combined therapy of acupuncture, moxibustion and low-power laser beam irradiation directed to an old post-cholecystectomy scar. An inflammatory reaction followed by granulation tissue mass was developed. Embedded in the granulation tissue were the above mentioned silk sutures which finally were expelled through the skin at the operation scar. A surgical procedure suggested to the patient, in case of acupuncture therapy failure, was obviously avoided. Serratia-marcescens infection of the expelled material was bacteriologically defined.

Abdomen↗
PubMed1988

Immobilization stress and direct glucocorticoid effects on rat septohippocampus.

The rat septohippocampal cholinergic system to a large extent regulates the adaptive physiological and behavioral response to stress. The mesoseptal dopaminergic (DA) system, one of the converging inputs to the lateral septum, exerts a tonic inhibitory action on the septohippocampal cholinergic neurons. High concentrations of pituitary-adrenocortical hormones in plasma may activate the septohippocampal cholinergic system. We have sought to determine whether this mode of activation may be directly initiated by hormonal action on the cholinergic terminals, or indirectly induced through an alteration in the DA septal inputs. The results indicate that stress initiates rapid and transient changes in DA uptake by septal DA terminals, changes which probably contribute to the initial transient activation of the hippocampal cholinergic system. While the effects of glucocorticoids, observed in vitro, may mimic the enhanced ACh release in stress, they do not mimic the increased choline uptake. Nevertheless, high glucocorticoid concentrations may act directly on septal dopaminergic terminals to reduce their DA uptake capacity. These results imply that the septohippocampal cholinergic activity represents an integrative pathway for neuronal and hormonal signals of stress.

Animals↗
PubMed1988

Systemic manifestations of erucism: a case report.

Larvae of the caterpillar Thaumetopoea wilkinsoni are widely distributed in pine groves throughout Israel. Erucism is defined as urtication by Lepidoptera larvae. Both irritating effects on contact with skin and eyes and toxic effects on ingestion have been described after exposure to several species of Lepidoptera. We report the case of a 4-year-old child who vomited repeatedly and developed symmetrical swelling of both hands after touching a larva of Thaumetopoea wilkinsoni.

Animals↗