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Biomedical subjects

Y F Roth

Publications and source records attributed to Y F Roth.

6 recordsLinked to original sources
PubMed1990

Osteoarticular allografts for reconstruction in the proximal part of the humerus after excision of a musculoskeletal tumor.

An osteoarticular allograft was used to replace the proximal end of the humerus in twenty patients who had had a wide excision of a bone tumor. Three patients needed a second allograft because the first became infected. All patients were followed for at least two years except for two patients who died. The functional results and complications of the twenty-three index procedures were evaluated. Function was excellent in one patient, good in eleven, fair in one, and poor in five. The allografts had advantages compared with other options for reconstruction (for example, prosthetic implants); these included restoration of the length of the bone, replacement of the articular surface, and sites for reattachment of the deltoid muscle and rotator cuff. We concluded that the complications do not preclude use of this procedure.

Adolescent↗
PubMed1988

Timing of chemotherapy and surgery in a murine osteosarcoma model.

The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.

Animals↗
PubMed1987

Eucaryotic primase.

Eucaryotic primase, an enzyme that initiates de novo DNA replication, is tightly associated with polymerase alpha or yeast DNA polymerase I. It is probably a heterodimer of 5.6 +/- 0.1 S. The enzyme synthesizes oligoribonucleotides of about eight residues which are always initiated with a purine. In vitro the polymerase-primase complex initiates synthesis and pauses at preferred sites on natural single-stranded templates. The relative concentrations of ATP and GTP present in the reaction medium modulate the frequency of site recognition. Primase is strongly ATP-dependent in the presence of single-stranded DNA and of poly(dT). It also synthesizes oligo(rG) in the presence of poly(dC) very efficiently.

Animals↗
PubMed1984

Increasing phantom limb pain as a symptom of cancer recurrence.

Previous studies have shown that phantom limb pain following major amputation reaches its greatest severity 2 to 3 weeks following amputation; it then gradually diminishes over subsequent months and years. Transient episodes of severe phantom limb pain are sometimes temporally related to specific activities such as urination, sexual intercourse, or local pressure applied to the amputation stump. Also, neuroma formation may be associated with transient episodes of increased discomfort usually associated with the application of local pressure. Phantom limb pain progressively increasing over an extended period of time has not been previously reported. The authors observed phantom limb pain of increasing severity to be associated with locally recurrent extremity sarcoma in two patients. In both patients increasing phantom limb pain was the first indication of recurrent cancer and led to radiologic studies and biopsy which confirmed the diagnosis of recurrent disease. It is suggested that phantom limb pain of progressive increasing severity may be a symptom of locally recurrent cancer in an amputation stump.

Adult↗