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Biomedical subjects

Y F Chan

Publications and source records attributed to Y F Chan.

At least 73 records · Page 4Linked to original sources
PubMed1989

Ovarian mucinous tumor with mural nodules of anaplastic carcinoma.

A case of mucinous cystic ovarian tumor with mural nodules of anaplastic carcinoma in a 30-year-old woman is described. The carcinomatous components within the nodules showed strong immunopositivity for cytokeratin and carcinoembryonic antigen, and ultrastructurally they displayed epithelial and glandular differentiation. Omental metastasis had already developed in the patient, and she received postoperative adjuvant chemotherapy consisting of cyclophosphamide and cis-platinum. No sign of recurrence was evident 4 months after the operation. The literature is reviewed and the importance of adjuvant chemotherapy in the postoperative management of such patients highlighted. The salient pathologic features differentiating mural nodules of anaplastic carcinoma and true sarcoma from prognostically favorable sarcoma-like nodules are presented.

Adenocarcinoma, Mucinous↗
PubMed1989

Congenital tuberculosis.

A 7 week old baby presented with generalized lymphadenopathy, obstructive jaundice and massive hepatosplenomegaly. The clinical picture closely resembled a case of disseminated malignancy. Soon after the diagnosis of tuberculosis was made by pathological examination of a lymph node, the patient died. An autopsy revealed primary tuberculous foci in the liver and massive lymphadenopathy at the porta hepatis consistent with transplacentally acquired tuberculosis. The importance of early diagnosis and treatment of this rare condition is emphasized.

Biopsy↗
PubMed1989

Clear cell chondrosarcoma: case report and ultrastructural study.

A case of clear cell chondrosarcoma in a Chinese patient is described. The clear cells showed strongly positive S-100 protein immunoreactivity. Ultrastructurally 2 types of chondroid cells were demonstrated. One type appeared more primitive with abundant electron-lucent cytoplasm and sparse organelles. The other type of cell was more differentiated with presence of microvilli and numerous dilated cisternae of endoplasmic reticulum. Previous ultrastructural studies on these lesions were reviewed and compared with the present findings.

Adult↗
PubMed1989

[Intraoperative anaphylactic shock--report of two cases].

Allergic reactions are often unpredictable, sudden in onset and may be potentially lethal. Clinical manifestations are confined to skin (rash, urticaria, angioedema), respiratory tract (laryngeal edema, bronchospasm) and cardiovascular system (hypotension, bradycardia, dysrhythymia). Because cardiovascular collapse is the most common life-threatening clinical feature, immediate and proper treatment is necessary. We have experienced two cases of intraoperative anaphylatic shock between September 1988 and April 1989. The precipitating factors were of nonanesthetic origin (case 1 was probably due to cephalothin and case 2 was due to dextran 40). Both cases manifestated with hypotension, bradycardia, cutaneous rash and urticaria. Recovery was smooth and without sequela after volume expansion and sympathomimetic drug. We discuss these two cases with a brief review.

Adult↗
PubMed1988

Presacral myelolipoma: case report with computed tomographic and angiographic findings.

A rare case of presacral myelolipoma in an otherwise healthy 53 year old man is described. His only complaint was lower abdominal discomfort. Full investigation including computed tomography and angiography revealed a well-delineated, heavily calcified, avascular retrorectal mass adhering to the presacral fascia. Histologically the mass showed a mixture of haemopoietic tissue and mature fat cells. Clinically the absence of symptoms and bone involvement served to distinguish this condition from other more sinister presacral lesions, particularly a chordoma.

Angiography↗
PubMed1988

Parapharyngeal inflammatory pseudotumor presenting as fever of unknown origin in a 3-year-old girl.

A parapharyngeal inflammatory pseudotumor in a 3-year-old girl who presented with high fever, anemia, and weight loss is described. The histologic differentiation from other fibroblastic lesions occurring in the head and neck region of a child is discussed. Symptoms improved dramatically after removal of the mass. The lesion may represent an exaggerated local response to an as yet unidentified agent with concomitant systemic manifestations.

Biopsy↗
PubMed1987

Recurrent dedifferentiated liposarcoma of the spermatic cord simulating malignant fibrous histiocytoma: an immunohistochemical and ultrastructural study.

A case of recurrent dedifferentiated liposarcoma simulating malignant fibrous histiocytoma, with complete absence of lipoblastic differentiation, is described. The tumour cells showed strongly positive immunostaining for alpha-1-antichymotrypsin. Electron microscopy revealed a mixture of fibroblasts and histiocytes. Our findings suggest that the dedifferentiated component reflects an altered differentiation pathway of the primitive mesenchymal cells in the original liposarcoma.

Aged↗
PubMed1986

Angiosarcoma of the thyroid. An immunohistochemical and ultrastructural study of a case in a Chinese patient.

A case of angiosarcoma (malignant hemangioendothelioma) developing in a chronic goitrous thyroid gland of an elderly Chinese woman is described. Histologically it showed the same classical appearance of angiosarcoma occurring in the skin and soft tissue. The endothelial origin of this tumor was confirmed by demonstrating Factor VIII-related antigen in the neoplastic cells with the immunoperoxidase technique and Weibel-Palade bodies by electron microscopic study. Because of its extreme rarity outside the European Alpine regions, many authorities are reluctant to accept it as a distinct entity and merely consider it as a variant of an undifferentiated carcinoma. Our report not only provides additional evidence that angiosarcoma of the thyroid gland is a specific condition of endothelial origin but also documents the first case among Chinese.

Aged↗
PubMed1986

Primary actinomycosis of the abdominal wall.

Two cases of primary actinomycosis of the abdominal wall masquerading as abdominal wall tumours are presented. The interesting clinical presentation and the difficulty in diagnosis are discussed.

Abdominal Muscles↗
PubMed1986

Infantile hemangioendothelioma of the liver: ultrastructural study of a type II case.

A case of infantile hemangioendothelioma of the liver presenting with congestive heart failure and massive hepatomegaly in a two-mth old baby is described. Serum alpha-fetoprotein was elevated in this patient and clinically the lesion might not be distinguishable from other, commoner hepatic tumours in children. Histologically the tumour showed a type II pattern as defined by Dehner. The significance of classifying this tumour into two histologic types is discussed. Only 3 cases reported in the English literature were studied by electron microscopy; two of them were type I while the other was a type II lesion. In our case the endothelial cells appeared ultrastructurally less differentiated and architecturally more disorganized than in type I lesions. Like the previous case, the basal lamina showed marked thickening and reduplication. The significance of these findings is discussed.

Basement Membrane↗
PubMed1986

Myxoma of the breast: report of a case and ultrastructural study.

A case of myxoma of the breast is presented. The differential diagnosis with respect to other myxoid tumours of the breast is discussed. Ultrastructurally the tumour cells show features of a primitive mesenchymal cell with possible pericytic or modified myoepithelial cell differentiation. The histogenesis is discussed.

Breast Neoplasms↗