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Biomedical subjects

Y Dodo

Publications and source records attributed to Y Dodo.

At least 55 records · Page 3Linked to original sources

[Results of radiotherapy of primary lung cancer with reference to metastases in regional lymph nodes].

The results of radiotherapy in the treatment of primary lung cancer is presented with reference to metastases in regional lymph nodes. The study involved 382 patients with histologically proven lung cancer of all cell types who, between 1945 and 1955, initially underwent definitive radiotherapy with TDF's of more than 70. The evaluable patients comprised 66 for N0, 177 for N1 and 139 for N2. Cumulative five-year survival rates for N0, N1 and N2 were 23.9%, 6.1% and 5.6%, respectively. Although surgical treatment before radiotherapy did not significantly improve a cumulative five-year survival rate for each N category, it kept patients alive longer for the median survival time (month). In 89 patients with involved mediastinal lymph nodes that specific sites were identified at the time of the surgical treatment (pN2), prolonged survival was obtained by radiotherapy if lymphatic spread was absent in the sites of #1, #2, #3, #5 and #6. If present, however, none of patients were alive at the post-treatment time of three years. As to 155 patients with stage III disease comprising T3 and/or N2, both cumulative five-year survival rate and median survival time showed better results in the group of N2 disease than those in T3.

Adenocarcinoma↗

[Intraoperative radiotherapy for locally advanced refractory cancer].

Clinical results of intraoperative radiotherapy (IOR) in carcinoma of the stomach and prostate, and malignant soft tissue tumors are reported. The 5-year survival rate was found to be increased by IOR in stages II-IV gastric cancer. From the analysis of the clinical results of prostatic cancer, a single dose of 3,500 rad was considered to be a potential curative dose for the tumor less than 3 cm in diameter. The local recurrence rate of patients with malignant soft tissue tumors who received a single dose ranging from 3,000 to 4,500 rad was 5.9 and the 5-year survival rate was 64.6%.

Aged↗

[Biological and physical approach to the improvement of radiotherapy].

A double blind trial of misonidazole (MISO) was undertaken. A total of 147 patients were enrolled. They were randomly allocated into two groups receiving either MISO or placebo. They were irradiated with 2 Gy 5 times a week to a total dose of about 60 Gy. 0.5g/m2 of MISO was given orally 4 hours before each irradiation. The effect of the treatment was evaluated as a decrease in the volume of the tumors. No radiosensitizing effect of the drug was observed. Twenty-nine tumors considered to be radioresistant were treated by RF hyperthermia combined with radiation. 48% of the tumors developed complete regression. No definite relationship between heat sensitivity of the tumors and their histological types was observed.

Animals↗

High intensity areas on noncontrast T1-weighted MR images in cerebral infarction.

Among 46 noncontrast magnetic resonance studies on patients with cerebral infarction, 11 showed areas of high signal intensity of the involved brain on T1-weighted images. These areas were more frequent in cerebral or cerebellar cortical lesions. Lacunar infarcts in lenticular nuclei, internal capsules, corona radiata, or brain stem did not show any high signal intensity areas on T1-weighted images, whereas the thalamic infarcts did. Sequential studies revealed that these lesions displayed low signal intensity on T2-weighted images at first, and then a high signal intensity area appeared on T1-weighted images. We suggest that these high signal intensity areas on the T1-weighted images in cerebral infarction are caused by hemorrhagic changes at the periphery of the infarction, where blood flow is restored by recanalization or collateral supply.

Adult↗

MR and CT appearance of urethral clear cell adenocarcinoma in a woman.

We present a case of clear cell adenocarcinoma of the female urethra that has been evaluated with CT and MRI. The lesion was a well-demarcated mass surrounded with peripheral enhancement on CT. On MRI a sharply marginated mass was located in the midurethra, giving rise to a smooth elevation of the bladder base. On T2-weighted imaging, the lesion was hyperintense, being surrounded by a ring of lower signal intensity at the periphery. A central urethral dot of lower signal intensity traversed the anterior one-third of the mass but was preserved in its entire length.

Adenocarcinoma, Clear Cell↗