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Biomedical subjects

Y Danon

Publications and source records attributed to Y Danon.

At least 37 records · Page 2Linked to original sources

Risk factors for infection in fracture war wounds (1973 and 1982 wars, Israel)

The development of post-surgical wound infection was compared in two groups of soldiers who sustained fractures or amputations on the battlefield during the first month of the 1982 and 1973 wars. Risk factors for the development of post-surgical wound infection were sought. In the 1982 group, numbering 184, the four variables independently associated with infection were multiple operations during the follow-up period; drains inserted in the first operation; extensive tissue loss; and blood transfusion during the first operation. For the 1973 group, numbering 130, the significant variables were multiple operations; amputations (highly correlated with extensive tissue loss); injury involving other body systems in addition to the fracture; and open drains. The high risk associated with open drains in both wars raises doubt about their usefulness. The main distinction between injuries of the two wars was the high prevalence (72.3%) of multi-system injuries in 1973 versus low prevalence (29.2%) in 1982. Overall infection rates were similar (30.5% and 31.5%), but infections at the site of the fracture were twice as high in 1982. Pseudomonas was the most common single species of bacteria isolated from infected wounds (26% in 1982, 33.6% in 1973). It appeared in the wounds relatively late, 10-14 days after admission.

Adult↗

Effect of pyridostigmine on the exercise-heat response of man.

The effect of pyridostigmine on thermoregulatory responses was evaluated during exercise and heat stress. Eight heat acclimated, young adult male subjects received four doses of pyridostigmine (30 mg) or identical placebo tablets every 8 h, in a double blind, randomized, cross-over trial. A 30.3%, SD 4.6% inhibition of the circulating cholinesterase (ChE) activity was induced in the pyridostigmine-treated group. The subjects were exposed to 170-min exercise and heat-stress (dry bulb temperature, 33 degrees C; relative humidity 60%) consisting of 60 min in a sitting position and two bouts of 50-min walking (1.39 m.s-1, 5% gradient) which were separated by 10-min rest periods. No differences were found between treatments in the physiological responses and heat balance parameters at the end of exposure: heart rate (fc) was 141 beats.min-1, SD 16 and 150 beats.min-1, SD 12, rectal temperature (Tre) was 38.5 degrees C, SD 0.4 degrees and 38.6 degrees C, SD 0.3 degrees, heat storage was 60 W.m-2, SD 16 and 59 W.m-2, SD 15 and sweat rate was 678 g.h-1, SD 184 and 661 g.h-1, SD 133, in the pyridostigmine and placebo treatments, respectively. The changes in Tre and fc over the heat-exercise period were parallel in both study and control groups. Pyridostigmine caused a slight slowing of fc (5 beats.min-1) which was consistent throughout the entire exposure (P less than 0.001) but was of no clinical significance. The overall change in fc was similar for both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Sociodemographic correlates of neutralizing poliovirus and hepatitis A virus antibodies as markers of different modes of acquiring immunity.

The prevalence and sociodemographic correlates of antibodies against poliovirus and hepatitis A virus (HAV) were compared in a random sample of 457 military recruits in Israel inducted during 1987. Lower socioeconomic status (SES) was associated with a higher prevalence of anti-HAV antibodies (67.3 vs 32.5 percent), whereas the reverse was true for type 1 poliovirus (78.4 vs 89.5 percent). While the high prevalence of anti-HAV antibodies observed in the lower SES groups reflects considerable natural exposure to enteroviruses, immunity against poliovirus appears to be determined primarily by compliance with vaccination.

Antibodies, Viral↗

Mucocutaneous lymph node syndrome (Kawasaki dIsease) in Israel. A review of 13 cases: is pseudomonas infection responsible?

In this report the clinical, laboratory and histopathological findings of 13 children with Mucocutaneous Lymph Node Syndrome (Kawasaki disease; MCLS) are reviewed. This is the first report of a series with a description of the clinical findings as well as pathological findings in patients from Israel. Pseudomonas infection appeared to be the underlying cause of both the clinical symptoms and the pathological changes of some (or all) cases of Kawasaki disease.

Adolescent↗

A conjugate of adriamycin and monoclonal antibodies to Thy-1 antigen inhibits human neuroblastoma cells in vitro.

Antibodies to the differentation antigen Thy-1 were linked via a dextran-hydrazide bridge to adriamycin. These monoclonal antibodies, which were previously prepared against first-trimester human fetal cells, reacted with several human brain tissue tumors such as neuroblastoma, glioma, and leiomyosarcoma through a common differentiation antigen, Thy-1. The conjugates were tested in vitro for their cytotoxic effects on a neuroblastoma cell line LA-N-I. The conjugate maintained its full drug and antibody activities. Moreover, the specific conjugate exhibited a higher efficacy in inhibition of RNA synthesis and was more cytotoxic than the nonspecific Ig-drug conjugate. Fluorescent microscopy showed that the specific conjugate was able to penetrate the cell membrane. Both the specific antibody and the drug were also observed to accumulate in the cell nucleus. Flow microfluorometric analysis of cellular DNA traverse showed that the specific antibody-drug conjugate caused a higher accumulation of neuroblastoma cells in stage G2 of the cell cycle than did the free drug, perhaps indicating a more efficient prevention of the progression of cells through mitosis.

Antibodies, Monoclonal↗