C-mitotic aggregations result from failure of cytokinesis.
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Cell Division↗
Biomedical subjects
Y Chamla
Publications and source records attributed to Y Chamla.
C-anaphases and their relationship with mitotic aggregation.
A survey carried out on lymphocyte chromosome preparations from 50 normal patients showed that the usual occurrence of C-anaphases is related to mitotic aggregations. This rule was not verified in variant and mutant patients exhibiting a high rate of C-anaphases.
Amniotic Fluid↗
Mitotic disturbances: about causality and terminology.
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Chromosome Aberrations↗
C-anaphases in lymphocyte cultures versus premature centromere division syndromes.
Different cases in which chromosomes obtained from short-term lymphocyte cultures appear with separated centromeres are reviewed. These include: (1) C-anaphases in the colchicine-resistance mutation, (2) C-anaphases as a common variant, (3) premature centromere division (PCD) in elderly women, (4) PCD in Alzheimer's disease, (5) early splitting and puffing of centromeres in Roberts' syndrome.
Anaphase↗
About diploid-tetraploid mosaicism.
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Cells, Cultured↗
Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability.
Colchicine-resistant human cells were initially observed in patients exhibiting C-anaphases or tetraploidy in lymphocyte cultures. Cell lines established from these patients displayed cross-resistances to daunomycin, emetine, vinblastine, and vincristine and collateral sensitivity to Xylocaine, showing a pleiotropic phenotype similar to that described in permeability mutants in CHO cells. 3H colchicine uptake and binding assays confirmed a decreased permeability to the drug.
Cell Line↗
Altered sensitivity to cholchicine and PHA in human cultured cells.
PHA-stimulated lymphocytes cultivated from a pair of human monozygotic twins yielded mostly tetraploid cells when colchicine was not used to arrest the metaphases. The rate of tetraploidy was also enhanced by colchicine in fibroblasts cultured without PHA. In in situ condition, larger than usual cells were observed. Other defects found in parental lymphocyte cultures included C-anaphase cells and increased cell aggregation. These results suggest a membrane mutation resulting in hypersensitivity to PHA and variant response to colchicine.
Cell Aggregation↗
Partial 9q trisomy associated with a 9,21 translocation.
A new case of partial trisomy 9q was found in a child presenting two de novo aberrations: a deletion of the long arms of 9 and a 9,21 translocation. A tentative cytogenetic explanation is put forward.
Chromosome Deletion↗
Production of C and T bands in human mitotic chromosomes after heat treatment.
A modified thermal denaturation of human chromosomes in Hanks' solution at 91 degrees C produces highly contrasted C and T bands. This improved double-banding system is a good tool in the analysis of ring chromosomes, for which R banding is often inadequate, as it is exemplified.
Chromosomes↗