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Y C Tong

Publications and source records attributed to Y C Tong.

At least 73 records · Page 4Linked to original sources

The University of Melbourne--nucleus multi-electrode cochlear implant.

To summarize, our preliminary results indicate that some prelingually deaf patients may get worthwhile help from a multiple-electrode cochlear implant which extracts formants. They can understand words and running speech better when using the cochlear implant with lip-reading compared to lip-reading alone. It has been encouraging that these improvements can occur in young adults and teenagers. It has also been encouraging that some can recognize place pitch as well as rate pitch. There are, however, considerable variations in performance and this may be due to the following factors: whether they have had some hearing after birth, the method of education used, the motivation of the patient and age at implantation. In conclusion it is important to emphasize that deaf children are severely disadvantaged however good their teacher of the deaf. Research on cochlear implants offers hope for profoundly-totally deaf children. These developments will not replace the caring, competent educators but complement their skills. There is also a greater need than ever for an interdisciplinary approach to these children.

Animals↗

Preliminary results for the cochlear corporation multielectrode intracochlear implant in six prelingually deaf patients.

The preliminary results from this study indicate that some prelingually deaf patients may get worthwhile help from a multiple-electrode cochlear implant that uses a formant-based speech processing strategy. It is encouraging that these improvements can occur in young adults and teenagers. The results for two children are also encouraging. A 10-year-old child obtained significant improvement on some speech perception tests. It was easy to set thresholds and comfortable listening levels on a 5-year-old child, and he is now a regular user of the device. There are, however, considerable variations in performance among the prelingual patients, which may be related to the following factors: whether they have had some hearing after birth, the method of education used, the motivation of the patient, and age at implantation.

Adolescent↗

Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines.

Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.

Animals↗

Loudness summation, masking, and temporal interaction for sensations produced by electric stimulation of two sites in the human cochlea.

Three psychophysical studies were conducted on two multichannel cochlear implant patients. The first study investigated the amount of loudness summation as a function of the spatial separation between two bipolar electrode pairs in the cochlea. Summation was found to increase in an orderly way with the separation between the two electrode pairs. This observation suggested that loudness was related to the distribution of discharge rate of auditory neurons along the cochlea for electric stimulation, and a model of loudness summation formulated on the basis of a functional relationship between loudness and the discharge rate distribution was proposed. The second study investigated the possibility of estimating the discharge rate distribution by means of masking. The amount of masking was found to decrease in an orderly fashion with the spatial separation between the masker and probe electrode pairs. This pattern of masking is consistent with the physiological and modeling observation that the current and neural discharge rate distributions produced by an electrode pair (masker) in the cochlea are approximately bell shaped with gradually decaying borders. The third study investigated the just-discriminable changes in the temporal delay between two interleaving pulse trains delivered, respectively, to two electrode pairs in the cochlea. Discrimination performance was found to decrease with the spatial separation between the two electrode pairs.

Cochlea↗

Absolute identification of electric pulse rates and electrode positions by cochlear implant patients.

In a single interval task, multichannel cochlear implant patients were asked to identify the members of a set of seven electric stimuli differing in electric pulse rate or electrode position. The perceptual sensitivity index (d') between successive stimuli in a stimulus set was calculated from the confusions among the seven stimuli. The results showed that the pulse rate above which the identification task became difficult varied from 200 to 600 pps from patient to patient. For the identification of the positions of seven bipolar electrode pairs, d' measures for stimulus sets differing in spatial separation or spatial extent were compared. Spatial separation is defined as the fixed distance between the two basal (or apical) electrodes of two successive bipolar electrode pairs in a stimulus set, while spatial extent is defined as the fixed distance between the apical and basal electrodes of each bipolar electrode pair in a stimulus set. The results showed that perceptual performance improved in an orderly way with spatial separation, but was not significantly affected by spatial extent.

Adult↗

Speech processing for cochlear implant prostheses.

The transformation of speech into electrical signals which can stimulate the auditory nerve in order to create hearing sensations that carry speech information depends on many factors. These include the limitations imposed by the current state-of-the-art in otological surgery, microelectronic and micromechanical technology, and knowledge of the functioning of the auditory system under both acoustic and electrical stimulation. Sufficient advances have been made in all these areas to enable several research centers to develop cochlear prostheses which give some hearing to certain totally deaf persons. The work of these centers towards the goal of full unaided speech perception via the prosthesis is examined and evaluated.

Adolescent↗

Clinical trial of a multi-channel cochlear prosthesis: results on 10 postlingually deaf patients.

The clinical trial of a multi-channel cochlear prosthesis has been carried out on 10 profoundly-totally deaf adult patients. Speech perception tests have shown that all the patients received significant benefit from the device. They obtained improvements in understanding running speech from 47% to 550% when using the device in conjunction with lipreading compared to lipreading alone. With an open-set CID sentence test, three patients obtained scores showing an ability to understand speech without the need to lipread, and a further three patients had scores indicating they could also receive useful information without lipreading. In two patients, very limited open-set scores for electrical stimulation alone were obtained. This was most probably due to the fact that only a few channels of stimulation were possible due to cochlear disease, and they were therefore receiving information more like a single-channel device. The prosthesis has also been found to provide considerable help in hearing and recognizing everyday sounds.

Adult↗

Underlying dimensions and individual differences in auditory, visual, and auditory-visual vowel perception by hearing-impaired children.

Vowel perception studies were conducted on a group of four adolescent children with congenital profound sensorineural hearing impairments in the three conditions of audition alone, vision alone, and audition plus vision. Data were analyzed using the ALSCAL multidimensional scaling procedure to identify the underlying dimensions and individual differences in dimension emphasis. The three dimensions obtained from the analysis of data for the audition alone condition were interpreted as the parameters of first and second formant frequencies, and vowel length. The one dimension for the vision alone condition was interpreted as the parameter of the width of the internal lip opening. The three dimensions for the audition plus vision condition were interpreted as the parameters of first formant frequency, vowel length, and the width of the internal lip opening. Subject variations in parameter preferences were observed for the audition alone and audition plus vision conditions but not for the vision alone condition.

Adolescent↗

An acoustic model of a multiple-channel cochlear implant.

A set of bandpass filtered, pulsed noise stimuli presented to three normally hearing subjects was found to have psychophysical properties similar to those of a set of pulsed electrical stimuli presented to two cochlear implant patients. Identical procedures were used to compare the performances of the two groups of subjects in the following tasks: (a) pulse rate difference limen measurements, (b) pitch scaling for stimuli differing in pulse rate, (c) pitch scaling and categorization of stimuli differing in filter frequency or electrode position, and (d) similarity judgments of stimuli differing in pulse rate and filter frequency or electrode position. By choosing the parameters of the acoustic stimuli appropriately, a high level of agreement between the two sets of results was achieved. Electrical stimuli on electrodes at different sites in the cochlea were matched with pulsed noise passed through bandpass filters with different center frequencies. Matching was achieved for equal electrical and acoustic pulse rates.

Adult↗

Speech processing studies using an acoustic model of a multiple-channel cochlear implant.

The speech perception of two multiple-channel cochlear implant patients was compared with that of three normally hearing listeners using an acoustic model of the implant for 22 different speech tests. The tests used included a minimal auditory capabilities battery, both closed-set and open-set word and sentence tests, speech tracking and a 12-consonant confusion study using nonsense syllables. The acoustic model represented electrical current pulses by bursts of noise and the effects of different electrodes were represented by using bandpass filters with different center frequencies. All subjects used a speech processor that coded the fundamental voicing frequency of speech as a pulse rate and the second formant frequency of speech as the electrode position in the cochlea, or the center frequency of the bandpass filter. Very good agreement was found for the two groups of subjects, indicating that the acoustic model is a useful tool for the development and evaluation of alternative cochlear implant speech processing strategies.

Aged↗

A signal processor for a multiple-electrode hearing prosthesis.

A 22-electrode implantable hearing prosthesis uses a wearable speech processor which estimates three speech signal parameters. These are voice pitch, second formant frequency and flattened spectrum amplitude. The signal is monitored continuously for periodicity in the range 80-400 Hz and, if this is present, stimulation occurs at the same rate. Otherwise, as in the case of unvoiced sounds, it occurs at the random rate of fluctuation of the signal envelope. The second formant is obtained by filtering to extract the dominant peak in the midband region and by continuous measurement of the zero crossing rate. The amplitude measured is that of the whole speech spectrum, pre-emphasized by differentiation. The values that are presented to the patient are the parameter estimates immediately prior to the stimulation pulse. Second formant frequency is coded by selection of an appropriate electrode in the cochlea and amplitude by a suitably controlled current. Automatic gain control is used to keep the dynamic range of the amplitude estimate within the 30 dB range of the circuitry.

Cochlear Implants↗

Clinical trial of a multiple-channel cochlear prosthesis. An initial study in four patients with profound total hearing loss.

The clinical trial of a multiple-channel cochlear prosthesis was undertaken in four patients with postlingual deafness and profound total hearing loss. The results of open-set speech tests confirmed that, using electrical stimulation alone, one patient could have a meaningful conversation without resorting to lipreading (for example, this patient uses the prosthesis to converse with her husband on the telephone). The results of closed-set speech tests also suggested that a multiple-channel stimulator is more effective than a single-channel one in conveying speech information. The cochlear prosthesis was especially effective in all four patients when it was used in conjunction with lipreading, and speech-tracking tests showed that the patients could combine the information obtained from both electrical stimulation and lipreading.

Adult↗

Two-component hearing sensations produced by two-electrode stimulation in the cochlea of a deaf patient.

Dissimilarities in perception elicited by stimulation with two electrodes were estimated. A two-dimensional spatial configuration was found to be suitable to represent the dissimilarity data, and the two dimensions could be interpreted as corresponding to the position of the apical and basal electrode of the two-electrode combination. A speech-processing strategy that converts acoustic, first and second formants to two-electrode stimulation is proposed.

Cochlea↗

Current distributions in cochlear stimulation.

Animal experimental studies have shown length constants of 2-4 mm for bipolar and 8-16 mm for monopolar stimulations. Studies in models using saline-solution-filled tubes have allowed us to examine the radial and longitudinal current distribution for pseudobipolar stimulation and have demonstrated that current localization is the same for bipolar and pseudobipolar stimulation over a 6-10-dB operating range. With coincident pseudobipolar multiple-channel stimulation there was suppression of the current between the stimulus maxima and enhancement at the edges leading to less stimulus interaction. Experiments performed with a pseudobipolar electrode implanted into the human cochlea showed that there was significant spread of current along the ground electrode because the electrode ground impedance was significantly greater than the cochlear tissue impedances. Because this leads to less current returned at each ground electrode, the pseudobipolar array will result in less interaction for coincident stimulation.

Animals↗

Percepts from scala tympani stimulation.

The characteristics of the sensations produced by activating one electrode at a time are summarized as follows: (a) Loudness was found to increase with current level and pitch with repetition rate. (b) Pitch and sharpness increased in the apical-to-basal direction, and vowel labels could be assigned to sensations produced by individual electrodes in accordance with the tonotopical organization of the cochlea. (c) Results from triadic comparisons provided evidence that the sensations produced by repetition rate and electrode position are perceptually separable. (d) For short-duration stimuli, the discrimination performance for electrode trajectories was much better than that for repetition rate trajectories. For noncoincidental two-electrode stimulation, triadic comparisons showed that two perceptual components, one related to the more basal electrode and the other to the more apical one, could be discerned. Speech-coding considerations based on these psychophysical results are discussed.

Cochlea↗