AIDS presenting as fever of undetermined origin: report of four cases.
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Acquired Immunodeficiency Syndrome↗
Biomedical subjects
Y C Liu
Publications and source records attributed to Y C Liu.
Cytoskeletal thermotolerance in NRK cells.
We investigated the effect of heat shock on the cytoskeletons (actin stress fibres, intermediate filaments and microtubules) and the relation between thermotolerance of cytoskeletons and thermotolerance as defined by clonogenic survival in normal rat kidney (NRK) cells. Upon heating at 45 degrees C for 15 min, almost all actin stress fibres were disrupted. During the recovery period after heat shock the stress fibres were reorganized rapidly and returned to their preheated state by 16 h. When the cells were heated again at 45 degrees C for 15 min, the disruption of stress fibres was less severe, indicating thermotolerant state of stress fibres. However, the thermotolerant state of stress fibres induced by prior treatment with sodium arsenite or by heating at 42 degrees C for 2 h was less evident than that induced by prior heat shock at 45 degrees C. The intermediate filaments in NRK cells were very heat-resistant; no apparent changes were observed even after heat shock at 45 degrees C for 60 min, and prior conditioning treatments could not induce thermotolerance of microtubules. All prior conditioning treatments could induce heat shock proteins and thermotolerance as defined by clonogenic survival. From these results it is suggested that there is no correlation between cytoskeletal thermotolerance and either heat shock protein level or thermotolerance as defined by clonogenic survival in NRK cells.
Actins↗
Acute suppurative thyroiditis in a primary intrathoracic goiter.
OBJECTIVE: To describe a case of acute suppurative thyroiditis and focal abscess formation in a patient with a primary intrathoracic goiter. METHODS: We summarize the initial clinical manifestations, the pathologic findings, and the surgical treatment of a woman with an enlarging mediastinal mass. RESULTS: A 41-year-old woman had a fever and a sudden increase in severity of compressive symptoms after a remote urinary tract infection. Smears from an intraoperative fine-needle aspiration biopsy showed necrotic debris, polymorphonuclear leukocytes, hemosiderin-laden macrophages, and degenerated follicular epithelial cells. Urine and tissue cultures grew Escherichia coli. The patient underwent resection of an 800-g primary intrathoracic goiter with associated degeneration, necrosis, hemorrhage, and abscess formation. CONCLUSION: To our knowledge, this is the first reported case of acute suppurative thyroiditis and abscess formation occurring within a primary intrathoracic goiter.
Journal Article↗
The predisposing factors of coagulase negative staphylococcal bacteraemia in neonatal intensive care unit.
Coagulase negative staphylococci are the commonest blood culture isolate from infants on neonatal intensive care units. The differentiation of contaminants from isolates representing true infection remains a significant clinical problem. Data from two neonatal intensive care units were collected prospectively in order to find those parameters, which best correlated with actual sepsis. Each case was assessed using clinical parameters to categorise infants into infection and contaminant groups. Logistic regression was then performed to find significant correlates. Three correlates were found, namely the presence of a long line (P = 0.001), abnormal white cell count (P = 0.037) and abnormal white cell morphology (P = 0.027). Abnormal white cell morphology was assessed by two experienced hematologists. More than half the isolates were probable contaminants and true infection may occur in the absence of a long line in this patient group.
Adrenal Cortex Hormones↗
Expression of a neuromodulin-beta-galactosidase fusion protein in primary cultured neurons and its accumulation in growth cones.
Cultured embryonic neurons share a number of characteristic morphological and physiological properties with their counterparts in vivo. For example, differentiating hippocampal neurons in culture develop two distinct classes of processes that serve as dendrites and axons. It has also been shown that the microtubule organization and composition in axons differs from those in dendrites, which may contribute to differential transport of macromolecules into axons or dendrites. We have expressed a neuromodulin-beta-galactosidase fusion gene in cultured mesencephalic neurons in order to study the transport of the neurospecific protein neuromodulin into neurite growth cones. When beta-galactosidase alone was expressed in neurons, it was found in the cell bodies with diffuse neurite staining. In marked contrast, the neuromodulin-beta-galactosidase fusion protein was rapidly transported into neurites and was concentrated in the growth cones. This system may provide a useful model for studying the structural domain(s) of neuromodulin that are required for transport and accumulation of neuromodulin in the growth cones of neurons.
Animals↗
Cutaneous abscess caused by Nocardia brasiliensis: report of a case.
We report a case of cutaneous Nocardia brasiliensis infection. The patient had received radiotherapy and anti-neoplastic chemotherapy for epidermoid carcinoma of the left sphenoid sinus with bone destruction. He developed fever and an ulcer on the dorsal medial surface of the left hand after an intravenous infusion of chemotherapeutic agents in the same site 3 days earlier. Needle aspiration of the abscess disclosed polymorphonuclear leukocytes, and a partially acid-fast, gram-positive filamentous branching organism. Cultures of the aspirate grew N. brasiliensis 1 week later. The patient was treated successfully with a regimen of parenteral ceftazidime and amikacin with definite improvement 1 week later. Therapy was continued for 1 more week, and then the patient was switched to oral trimethoprim-sulfamethoxazole for 3 months with no recurrence. The diagnosis, clinical manifestations, treatment and prognosis of cutaneous abscesses cause by N. brasiliensis are discussed.
Abscess↗
China: traditional healing and contemporary medicine.
This paper shows how the health professions must meet the demands posed by China's vast geographical area, her population problem, her increasing technological development and economic situation, by utilizing available health resources as well as manpower in order to fulfil 'the national guarantee--to serve the people'.
China↗
China: health care in transition.
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China↗