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Biomedical subjects

Y Baram

Publications and source records attributed to Y Baram.

4 recordsLinked to original sources

Random embedding machines for pattern recognition.

Real classification problems involve structured data that can be essentially grouped into a relatively small number of clusters. It is shown that, under a local clustering condition, a set of points of a given class, embedded in binary space by a set of randomly parameterized surfaces, is linearly separable from other classes, with arbitrarily high probability. We call such a data set a local relative cluster. The size of the embedding set is shown to be inversely proportional to the squared local clustering degree. A simple parameterization by embedding hyperplanes, implementing a voting system, results in a random reduction of the nearest-neighbor method and leads to the separation of multicluster data by a network with two internal layers. This represents a considerable reduction of the learning problem with respect to known techniques, resolving a long-standing question on the complexity of random embedding. Numerical tests show that the proposed method performs as well as state-of the-art methods and in a small fraction of the time.

Journal Article↗

Manifold stochastic dynamics for Bayesian learning.

We propose a new Markov Chain Monte Carlo algorithm, which is a generalization of the stochastic dynamics method. The algorithm performs exploration of the state-space using its intrinsic geometric structure, which facilitates efficient sampling of complex distributions. Applied to Bayesian learning in neural networks, our algorithm was found to produce results comparable to the best state-of-the-art method while consuming considerably less time.

Journal Article↗

V delta 2+ gamma delta T lymphocytes are cytotoxic to the MCF 7 breast carcinoma cell line and can be detected among the T cells that infiltrate breast tumors.

In order to study the potential role of gamma delta T lymphocytes in cytotoxicity against breast carcinoma cells, normal peripheral blood gamma delta cells were isolated and triggered with an alloantigenic lymphoblastoid B cell line and recombinant interleukin-2 and cloned. The clones expressed a CD3+V gamma 9+V delta 2+CD4-CD8- (or CD8+) phenotype. Five clones were cytotoxic to the Molt 4 T cell leukemia, but not to the alloantigen, whereas one clone lysed the alloantigen, but not the Molt 4 line. Clones that were cytotoxic to Molt 4 were either spontaneously cytotoxic against MCF 7 breast carcinoma cells or could be induced to kill MCF 7 cells by monoclonal antibodies specific for the gamma delta T cell receptor. In situ staining demonstrated that V delta 2+ as well as other subsets of gamma delta T cells can be detected in the lymphocytic infiltrate within breast carcinomas. These data showing that V delta 2+ T cells can recognize and kill cells of breast carcinoma lineage in vitro, and that cells expressing V delta 2 genes in their T cell receptor structure can be detected in the tumor, suggest that further studies of the nature of the interactions between V delta 2 T cells and breast carcinoma cells are warranted.

Antibodies, Monoclonal↗