Search PubMed⌕ Search

Biomedical subjects

Y Asai

Publications and source records attributed to Y Asai.

At least 271 records · Page 15Linked to original sources
PubMed1980

[Vaginal fungi in toxemia of pregnancy (author's transl)].

In order to prevent the transfer of the fungi in maternal vagina into a neonate through transvaginal delivery, we examined the presence of vaginal fungi in the patients with toxemia of pregnancy occurring chiefly from the later stages of pregnancy and made an analysis from the quantitative aspect of fungi (number of colonies produced on Mizuno-Takada medium). The results obtained are as follows: 1) The detection rate of vaginal fungi was evidently so high as 37.1% in toxemia group compared with 27.6% in non-toxemia group (p less than 0.01). And the detection rate of vaginal Candida albicans (hereinafter: C. albicans) also proved to be higher tendency in toxemia group. 2) When the toxemia patients were divided into mild cases and severe ones for comparison, the detection rate of vaginal fungi and that of vaginal C. albicans were both higher in the severe case group. Particularly in the group which had the symptoms of toxemia at the examination time of vaginal fungi there was seen the higher rate. 3) From the quantitative aspect of vaginal fungi it is evident that there were more cases with over 51 colonies in the group showing the symptoms of toxemia at the time of fungi examination than in the group showing no such symptoms at the examination and the group of non-toxemia (p less than 0.01).

Candida albicans↗
PubMed1980

[Surgical treatment for cerebral metastasis of choriocarcinoma (author's transl)].

1. The findings of 30 cases of cerebral metastasis of choriocarcinoma on autopsy were analysed in relation to their localization, depth, and number, and it was proven that the cerebral metastasis was neurosurgically resectable in most cases. 2. Thirty-five cases of choriocarcinoma with cerebral metastasis were treated at Nagoya University Hospital. Twenty-four out of 26 cases treated by chemotherapy alone died within 2 months after the manifestation of cerebral metastasis. Whereas 6 out of 9 patients treated by chemotherapy and surgery survived for over 2 months. Four cases among them survived over 6 months. The lifesaving effects of surgery were marked in this group. 3. Surgery was thought to be especially effective on those patients satisfying the following 3 conditions: I) Degree of brain damage is not severe. II) The lesion is localized at removable site, and the post-operative sequela is anticipated to be insignificant. III) The chemotherapy was not proven to be ineffective. 4. Cerebral metastasis of choriocarcinoma should be treated as follows. If symptoms of increased intracranial pressure are present, removal of tumor or, at least, decompression should be immediately performed. Multi-drug chemotherapy and whole-brain irradiation should be started within several days after surgery. If symptoms are not present, chemotherapy combined with irradiation is the first treatment of choice.

Adult↗
PubMed1978

Stepwise acquisition of multiple drug resistance by beta-hemolytic streptococci and difference in resistance pattern by type.

We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics were assayed by the standard method. Resistant strains from the above collection were classified according to group, T-type, and drug resistance pattern. Our data on T-types for 1964-1971 and on drug resistance for 1966-1971 were used to interpret the detected long-term variations in T-type and drug resistance. The stepwise acquisition of multiple drug resistance, the difference in resistance pattern between predominant T-types, and the rarity of single-macrolide resistance were demonstrated.

Anti-Bacterial Agents↗
PubMed1978

Long-term results of bypass grafts for atypical coarctation of the thoracic aorta.

Long-term results of bypass grafts for atypical coarctation of the thoracic aorta are presented. Six of the 13 patients with atypical coarctation were treated with long bypass from the descending thoracic aorta to the abdominal aorta. One of them had correction of right renal stenosis with a saphenous vein graft. Late clinical results of surgery (average follow-up time 4 years, 5 months and the longest over 10 years) were excellent, except for one patient who died 3 1/2 years postoperatively of acute abdomen. This experience suggests that atypical coarctation of the aorta can be treated satisfactorily by the long thoraco-abdominal bypass graft technique. If unilateral or bilateral renal artery stenosis is found simultaneously, renal revascularization is also necessary to obtain normalization of the blood pressures.

Adolescent↗
PubMed1978

Eruptions. Possible involvement of carrier contained in cutaneous tissues.

In some types of drug eruptions, a positive blastoid transformation is frequently seen in peripheral lymphocytes when they are stimulated in vitro with the causative drug in the presence of autologous serum. In these cases, a soluble fraction prepared from guinea pig skin can replace the autologous serum in inducing the lymphocyte fransformation, whereas either the mitochondrial or microsomal fraction of guinea pig skin instead of the autologous serum is less effective. Moreover, in fixed drug eruption, the addition of soluble skin material fractionated by gel filtration with Sephadex G-100 (FrD1) is as effective as the autologous sera in inducing lymphocyte transformation. These results suggest that the soluble fraction of skin is related to the pathogenesis of fixed and exanthematic drug eruptions as a carrier substance of drugs.

Adult↗