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Biomedical subjects

Y Asai

Publications and source records attributed to Y Asai.

At least 235 records · Page 13Linked to original sources
PubMed1982

Acral syringoma: electron microscopic studies on its origin.

A case of acral syringoma associated with the usual eruption on the lower eyelids was examined by light and electron microscopy for the first time. In the upper dermis there were a few ducts and cystic formation, while predominant atypical solid strands composed of tumor cells were often seen by light microscopy. Electron microscopy showed the formation of small ducts in the solid strands and numerous microvilli with a pinching off of the luminal tumor cells. A large number of multivesicular dense bodies (mvb) and keratohyalin granules were also found in the periluminal tumor cells. The ducts resembled embryonic intra-epidermal ducts. The unusual anatomical sites of eruption and the electron microscopic findings suggest an eccrine intra-epidermal duct origin of acral syringoma.

Adenoma↗
PubMed1981

Primary reconstruction of cheek defect following excision of a large malignant melanoma: Report of a case.

A large malignant melanoma of the cheek with metastasis to a submandibular lymph node is described. The tumor was successfully treated by surgical excision and radical neck dissection followed by immunotherapy with intradermal injections of CWS (cell wall skeleton) of noocardia. The cheek and upper lip defects following tumor excision were reconstructed primarily by upward rotation of the cheek and neck skin flap and by lateral advancement of a full-thickness upper lip flap. The oral defect was closed by stretching the distal based mucosal flap from the lower half of the buccal mucosa.

Aged↗
PubMed1981

Macular amyloidosis with patchy filamentous degeneration of collagen islands.

Unusual patchy filamentous degeneration of collagen islands, found in a typical case of macular amyloidosis, is described. This phenomenon was found to begin in intact islands scattered among the amyloid islands in the papillary and upper reticula dermis. Since the patches varied in size, they were thought to have grown gradually with time. They were derived from the degeneration of collagen fibrils and demonstrated a tropocollagen-like structure. Although the small patches preserved some characteristic structures of collagen fibrils or tropocollagen, the large patches showed amyloid-like filamentous masses surrounding the collagen islands.

Amyloidosis↗
PubMed1981

Effects of phenobarbital on plasma concentration of phenytoin and mortality of mice treated with phenytoin after electroshock.

THe effects of phenobarbital on the plasma concentration of phenytoin and mortality of the phenytoin-treated mice were mainly studied. The plasma concentration of phenytoin estimated in the live mice after electroshock was significantly higher than that in the dead mice, suggesting that biological activity of phenytoin is dependent on its plasma concentration where individual difference seems to be large. Though the pretreatment of mice with phenobarbital lowered the plasma concentration of phenytoin, all the mice were alive after electroshock with further treatment with phenobarbital and phenytoin. These results suggest that combination of phenobarbital with phenytoin for the treatment of epileptic patients may be feasible.

Animals↗