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Biomedical subjects

Y Arima

Publications and source records attributed to Y Arima.

52 records · Page 3Linked to original sources
PubMed1987

Lipstick dermatitis due to C18 aliphatic compounds.

An 18-year-old girl developed cheilitis. She had a past history of lip cream dermatitis, but the cause was not found. Patch tests with 2 lipsticks were strongly positive. Tests with the ingredients were positive to 2 aliphatic compounds, glyceryl diisostearate and diisostearyl malate. Impurities in the materials were suspected as the cause. Analysis by gas chromatography detected 3 chemicals in glyceryl diisostearate and 1 in diisostearyl malate as impurities. Patch testing with the impurities and glyceryl monoisostearate 0.01% pet in glyceryl diisostearate and isostearyl alcohol 0.25% pet in diisostearyl malate were strongly positive. The characteristics common to the 2 chemicals were liquidity at room temperature, branched C18 aliphatic compound and primary alcohol. Chemicals lacking any of the above 3 features did not react.

Adolescent↗
PubMed1987

Depigmented contact dermatitis due to incense.

A 63-year-old male school teacher with itchy depigmented macules on his left dorsum manus, left shoulder and abdomen presented at our clinic on 8 July 1986. He had practiced the incense ceremony for about 15 years, and had burnt several incenses and sandalwood. 48 h closed patch testing revealed perfume in the incenses was the cause. We assumed that perfume in the incense was volatized in air when incense was burnt; skin surface contact occurred with airborne particle, which dissolved in sebum; thus allergic contact dermatitis accompanied by depigmentation might arise.

Dermatitis, Contact↗
PubMed1987

Is sesamol present in sesame oil?

Sesame oil has been reported to contain sesamolin, sesamin and sesamol as contact allergens. A female patient had cheilitis due to sesame oil in a lipstick. She reacted to sesamolin and sesamin, but not to sesamol. We carried out analysis of the sesame oil by high performance liquid chromatography. We detected sesamolin and sesamin but not sesamol in sesame oil.

Adult↗
PubMed1983

Purification and characterization of bovine placental lactogen.

Bovine placental lactogen (bPL) was purified 4,200-fold from cotyledon homogenates by 1) salt precipitation and 2) ultrafiltration, followed by 3) gel filtration, 4) anion exchange, 5) hydroxylapatite, 6) chromatofocusing, and 7) final gel filtration chromatography. Purification was monitored by radioreceptor assay (RRA) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. During chromatofocusing, three distinct peaks of bPL were eluted: a small peak at pH 5.34 (bPL-1), a larger peak at pH 5.09 (bPL-2), and the largest peak at pH 4.84 (bPL-3). These three were further purified separately by the final gel filtration. The purified bPLs were compared with bovine (b) PRL (0.81 IU/mg) and bGH (30 IU/mg) by RRA. The bPRL-like activities were 67.1, 750, and 1,090 micrograms/mg, and the bGH-like activities were 74.4, 787, and 715 micrograms/mg for bPL-1, bPL-2, and bPL-3, respectively. In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the molecular weights of all bPLs were the same, 31,100. In gel filtration under nondenaturing conditions, all bPLs had a 40,000 mol wt, with a Stokes radius of 2.70 nm. The isoelectric point (pI) of bPL-1 was higher than 5.85, the pI of bPL-2 was 5.52, and that of bPL-3 was 5.39. The amino acid compositions of bPL-2 and bPL-3 were virtually identical, except that bPL-3 had a few more acidic amino acids. Both bPL-2 and bPL-3 had an estimated 277 amino acid residues. Thus, bPL appeared to have both PRL- and GH-like activities equivalent to bPRL and bGH in the RRA on a mass basis, to be 50% larger than bPRL, bGH, and PLs in other species, and to occur in at least three different forms differing in their pI values and in their acidic amino acid compositions.

Amino Acids↗
PubMed1982

A 32,000-molecular weight protein from bovine placenta with placental lactogen-like activity in radioreceptor assays.

Considerable discrepancies exist in the literature concerning the size and activity of bovine placental lactogen. Our bovine placental lactogen purification preparations were 20% as active as bovine PRL (bPRL) on a per weight basis when compared to bPRL in a lactogenic radioreceptor assay. To identify the active component in these preparations, the proteins were radioiodinated and bound to membrane receptors in the presence and absence of competing hormones, bPRL, and bovine GH (bGH). After centrifugation, membrane pellets were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and the gels were autoradiographed. Only one radioiodinated protein band was present. This protein was displaced in the presence of competing hormone and comigrated which a major component of the purification preparations. In radioreceptor assays the active component was as active as bPRL and bGH. From the migration of protein standards included with the radioiodinated purification preparations in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, we estimate that the protein is 32,000 mol wt--about 10,000 mol wt larger than placental lactogens isolated in other species. The possibility that the active molecule was a precursor protein was investigated by examining proteins secreted by bovine placenta tissue cultures. The binding activity in these secretions, as well as in the purification preparations, eluted between ovalbumin (43,000 mol wt) and bPRL (22,000 mol wt) under nondenaturing conditions using high performance gel filtration chromatography. Analysis of this secreted protein, also by binding to membrane receptors, showed that the protein had the same molecular weight as that isolated from the purification preparations and was specifically displaced by the same hormones.

Animals↗
PubMed1982

[Simultaneous measurement of 32P and a 33P double-labelled sample by liquid scintillation counter and its application to phosphorus compounds isolated by paper chromatography].

Simultaneous determination of 32P and 33P radioactivities was carried out with the liquid scintillation counter (Aloca LSC 670). For the quenching correction, the channel ratio method was used, and the proper gain and window level were set to get the maximum performance number or Klein-Eisler value. Using this method the radioactivities of the 32P and 33P double labelled compounds which were separated with paper chromatography were determined. New index, RSA (relative specific activity, i.e. 32P/33P) was proved to be effective as well as specific activity for the studies of the transport and metabolism of phosphorus compounds in the plant roots.

Chromatography, Paper↗
PubMedDate not supplied

New techniques: splenic artery embolization followed by intraarterial infusion chemotherapy for the treatment of pancreatic cancer.

We present a new intraarterial infusion chemotherapy technique for the treatment of inoperable cancer in the body and tail of the pancreas. The spleen was embolized at its hilum with coils to infuse an anti-tumor agent selectively into the pancreatic parenchyma and a catheter was placed into the splenic artery and connected to the reservoir. 99mTc-macroaggregated albumin+diethylenetriaminepenta-acetic acid (MAA+DTPA) was injected into the reservoir and the body and tail of the pancreas were visualized on the image. For inoperable cancer in the body and tail of the pancreas, splenic artery embolization followed by the placement of a catheter into the splenic artery can deliver a highly concentrated anti-tumor agent to the tumor.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Experience with intraarterial infusion of styrene maleic acid neocarzinostatin (SMANCS)-lipiodol in pancreatic cancer.

A 54 year-old man was admitted to our hospital and diagnosed with inoperable cancer in the body and tail of the pancreas. The spleen was embolized at its hilum with a coil to infuse an anti-tumor agent selectively into the pancreatic parenchyma and transcatheter intraarterial infusion (TAI) of styrene maleic acid neocarzinostatin (SMANCS)-Lipiodol, 3 mg, was performed. The computed tomography (CT) scan taken immediately after TAI revealed the incorporation of SMANCS-Lipiodol into the site of the pancreatic tail. At 2 weeks, a small amount of SMANCS-Lipiodol remained and clearness of the tumor margin was lacking in the pancreatic tail, but no remarkable change was noted in the body. As for the laboratory data, pancreatic enzyme level was not elevated immediately after TAI. At 2 weeks, tumor markers showed improvement in CEA (3.9-->2.6 ng/ml) and Elastase 1 (370-->230 ng/ml), but little change was seen in CA 19-9 (1600 U/ml: no change) and DUPAN-2 (730-->740 U/ml). In pancreatic cancer, SMANCS-Lipiodol could be infused from the splenic artery into the pancreatic parenchyma by the splenic arterial embolization.

Antineoplastic Agents↗
PubMedDate not supplied

Colonic varices ruptured via drainage catheter after extended right hepatectomy.

Extended right hepatectomy was performed on a 69-year-old woman with bile duct carcinoma of the hepatic hilum. Three weeks after the operation, an abscess was detected at the resected surface and a drainage catheter was inserted. The patient was discharged with the drainage catheter in place and followed-up at a local hospital. Three months later, the drainage catheter was removed. Bleeding immediately occurred through the fistula, and fistulography revealed varices. Angiography demonstrated right colonic varices, and the fistula was embolized with coils. There was no further bleeding. In conclusion, colonic varices that ruptured via a fistula of a drainage catheter were embolized through the fistula. Embolization of the fistula was useful in stopping the bleeding.

Aged↗