[Epidemiological study on chronic atrophic gastritis. I. Its relation with food habits of several races (author's transl)].
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Biomedical subjects
Publications and source records attributed to Y Akasaka.
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Endoscopic examination using a specially designed sonde-type small intestinal fiberscope (SSIF, Olympus) was performed in 37 patients of our clinic. The improvement of the scope has enabled us to observe the greater parts of the small intestine within a short time and without hazard to the patient. Therefore, with further improvement of this instrument and the insertion technique, we will be able to inspect all parts of the small intestinal mucosa and diagnose the lesions more easily.
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Endoscopic gastroelectromyograms were obtained from 8 patients with gastric cancer, which was located at the gastric antrum. These cancers include 6 cases of advanced cancers and 2 cases of early cancers with mucosal invasion. On healthy volunteers, the gastroelectromyograms from the gastric antrum showed spike bursts with equal intervals. On the other hand, in the patients with advanced cancers on which muscular layer was completely destroyed by the cancerous invasion, the gastroelectromyograms from the cancerous lesion showed no spike bursts. However, in the patients with mucosal cancers in which the cancerous invasion destroyed neither muscular membrane nor muscular layer, the gastroelectromyogram from the cancerous lesion showed spike bursts similar to those of healthy volunteers. From these results, it is proved that the deeper cancerous invasion disturbed the local motility at the cancerous lesion. In future, endoscopic lead of gastroelectromyogram will become useful for the diagnosis of the degree of cancerous invasion and infiltration.
Recently we made the electromyographic study on human gastrointestinal tract using the endoscopic method is useful for the clinical studies of the patho-physiological aspects on human gastrointestinal tract. The silver bipolar needle electrode which was 0.2 mm in diameter, 10 mm in length and 1.0 mm in interpolar distance and the electroencephalography recorder provided with pen-writer were used for this research. The endoscopy was done to the volunteer anesthetized his pharynx with xylocaine spray. 20 cases of gastro-electromyograms, 35 cases of duodeno-electromyograms and 5 cases of the electromyograms of duodenal papilla were recorded. On these endoscopic electromygorams, the typical rhythms and patterns of electrical activities were disturbed by various kinds of factors; that is, on the endoscopic manipulation, the sticking of needle electrode into the shallow layer of gastrointestinal wall and automatical pouring of water into canal through the endoscope. On volunteers' condition, his deep breathing, electrocardiogram and vasotonic condition were important factors. Typical duodeno-electromyograms showed the grouped spikes synchronizing with the duodenal peristalsis observed endoscopically. The electromyograms of the duodenal papilla showed the similar patterns and rhythms to those of duodeno-electromyograms on active phase. In the clinical study on the correlation and propagation between gastric and duodenal motility, the rhythms of electrical activities on duodeno-electromyograms were not similar to the rhythms of gastric peristalsis at the prepyloric region. The propagation of gastric movement to duodenal bulb were not able to be clarified. We assumed that the gastric and duodenal motility occurred each other on the different rhythms.
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A new very thin glass fiber endoscope ("baby scope") has been developed, which can be passed through the channel of a modified duodenoscope ("mother scope") for catheterization of the choledochus or of the pancreatic duct. Peroral choledocho-pancreatoscopy (PCPS) was performed in 9 patients, the endoscopic results are presented. Other new auxiliary instruments for diagnostic or therapeutic purposes in biliary or pancreatic diseases are described: a brushing catheter, a special biopsy forceps, a retention probe and a balloon-tipped catheter.
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Endoscopic sphincterotomy of the ampulla of Vater was performed in seven patients suffering from gallstones in the common bile duct and/or bile flow stasis. After this procedure, spontaneous delivery of gallstones occurred in two cases and a gallstone was extracted by our basket-tipped catheter in two cases. The electromyogram of the sphincter of Oddi after endoscopic sphincterotomy showed the similar patterns and rhythms to those before this procedure. Thus, the function (bile flow mechanism) of the sphincter was not destroyed by this procedure. Morphologic and physiologic data, therefore, lead to the conclusion that endoscopic sphincterotomy is a safe and useful procedure.
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