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Biomedical subjects

Y Akahonai

Publications and source records attributed to Y Akahonai.

36 records · Page 2Linked to original sources
PubMed1984

[An autopsy case of extramedullary plasmacytoma with systemic dissemination 2 years after the onset of a localized tumor in the nasal cavity].

A 73-year-old male was admitted because of a localized tumor in the nasal cavity, which was suspected to be malignant lymphoma by biopsy specimens. Laboratory findings were within normal limits except for small amounts of M protein (IgG-lambda) in the serum. The patient was successfully treated by radiotherapy, with the disappearance of both the tumor and M protein. Two years after the onset, however, a solid tumor was observed in the soft tissue, followed by rapid systemic dissemination. An increase in M protein was obvious, and the biopsy specimens disclosed plasmacytoma. The patient died three months after admission, and post-mortem examinations revealed a diffuse infiltration of plasmacytes predominantly in the soft tissues.

Aged↗
PubMed1983

Distribution of secretory component in non-cancerous human gastric mucosa.

Immunological detection of secretory component (SC) in non-cancerous human gastric mucosa was carried out by the peroxidase-anti-peroxidase (PAP) method using several fixatives. SC was detected in the generative zone or mucous neck of normal gastric mucosa without intestinal metaplasia (IM) and in absorptive cells of IM of the stomach. The deep part of complete type IM showed a larger amount of SC than the superficial part. These findings suggested that the appearance of SC in gastric mucosa would be relevant to the immunity of glandular epithelium. In addition, SC was also detected in pyloric gland cells in specimens fixed with cold 95% ethanol. From these results, SC was considered to be a normal constituent and one of the developmental proteins in the gastric mucosa.

Gastric Mucosa↗
PubMed1982

[Fundamental studies with respect to plasma exchange by using continuous-flow centrifuge system and the clinical trial in patients with myasthenia gravis].

A plasma exchange by using the continuous-flow centrifuge blood cell separator (IBM 2997) was carried out in 13 patients with various diseases including myasthenia gravis. The effects of the plasma exchange on blood components and side effects during the procedure were evaluated. In addition, 5 cases with severe myasthenia gravis who had failed to respond to medication were treated by plasma exchange, and the results were as follows: 1. Red blood cells, hemoglobin and hematocrit levels were significantly decreased while white blood cells inclined to increase after plasma exchange. In serum electrolytes and proteins there were no changes. 2. The side effects such as itching and eruption were observed in 46% of the patients. However, they disappeared within a short period. 3. In 2 cases with myasthenia gravis, a significant improvement in muscle weakness was observed by plasma exchange. In these cases, serum levels of the acetylcholine receptor antibody and the circulating immune complex were decreased, as compared with the previous levels. These parameters showed no correlation with severity of the disease.

Adult↗
PubMed1978

Studies on the CEA-like substance in gastric juice.

Concentration and heterogeneity of CEA-like substance in gastric juice were studied using radioimmunoassay. Statistically significant increase of CEA-like substance in gastric juice was found in advanced atrophic gastritis (P less than 0.01), early gastric cancer (P less than 0.05) and advanced gastric cancer (P less than 0.01) as compared with normal subjects. In cases with atrophic gastritis with a high degree of intestinal metaplasia, the concentrations above 300 microgram/dl were noticed. The results indicate that increased concentrations of CEA-like substance in gastric secretions may strongly suggest the presence of a marked intestinal metaplasia and/or cancerous changes of gastric mucosae, including the early cancer. The distribution of CEA activity in gel filtration fractions of gastric juice was compared using kits of two different radioimmunoassay systems. The patterns of CEA activities were different between the two different kits used, but the main peaks were located in the fractions with the molecular weight of 20x10(4) daltons corresponding to that of serum CEA. It is considered, however, that the CEA-like substance in gastric juice specimens may be more or less heterogenous when any of the methods is used.

Carcinoembryonic Antigen↗
PubMed1975

Clinical significance of alpha2H-globulin.

Incidences of alpha2H were investigated in sera from patients with various malignant and nonmalignant diseases. With counterimmunoelectrophoresis, alpha2H was detected in a wide variety of neoplastic diseases, and also in nonmalignant hematological disorders. Diagnostic significance was described regarding primary hepatoma and acute myelogenous leukemia. Factors affecting alpha2H levels in sera were also discussed in relation to the neoplastic and nonneoplastic disease process.

Alpha-Globulins↗