[Aortocoronary bypass surgery to an obstructed right coronary artery due to blunt chest trauma--a case report].
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Biomedical subjects
Publications and source records attributed to Y Ago.
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The atopic disposition, indicated by positive skin reactions and IgE antibody titers etc., and the bronchial reactivity to inhaled acetylcholine were examined on the following three groups: (1) 20 young adults with a history of childhood asthma who have been symptom-free for more than 4 yr; (2) 20 current asthmatics, and (3) 20 healthy young adults. Young adults with a history of childhood asthma remained atopic in their disposition even after complete clinical remissions of their childhood asthma. However, they had a lower bronchial reactivity as compared with current asthmatics, although the bronchial reactivities of both groups were apparently higher than the control group.
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The effect of stress on production of immunoglobulin E (IgE) in rats was investigated, the IgE being titrated by passive cutaneous anaphylaxis (PCA) reactions. In rats, exposed to attack by other rats made aggressive by intraventricular injections of 6-OHDA for one hour per day for three consecutive days before the first immunization, there was no difference in the titer of IgE as compared to the control rats, but, in the rats exposed to stress procedure before the second immunization, the production of IgE was significantly suppressed.
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The psychosomatic aspects of skin disease were studied both clinically and experimentally, from the standpoint of immunology. We found that emotional stress has a great influence on the immune system, as was manifested in skin disease. Skin test in allergic patients significantly improved with autogenic training and relaxation. For clarification of the effects of autogenic training and relaxation, various parameters were simultaneously assessed during the treatment. The serum levels of histamine and dopamine-beta-hydroxylase fluctuated, as determined by the microvibration test. The levels of IgE and findings on the PK test varied only slightly. Before the onset of urticaria, there were changes in the life-style and considerable stress in daily life as well as exposure to an allergen. Using mice subjected to stress, the functions of T cells and macrophages were evaluated. Stress appeared to have a definite influence on the functions of these cells, as related to the important role of the immune system and skin. Thus, the role of stress in clinical disease must always be given consideration.
In this study, the authors discuss whether there are any differences in the acquired factors, such as psychosocial factors, related to the age at the onset of psychosomatic disorders, and whether or not there are any characteristics which can be considered unique to Japanese asthmatic patients. Many firstborns were found in those whose onset age was below 10 or in their teens. In those patients who had the onset of asthma in their 20s or 30s many women suffered problems with their mother-in-law after marriage or with their husbands who were interested only in work. We have also discussed that behind these phenomena, problems of parent-child relationship in early childhood were hidden.
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A case of cold urticaria, thought to be due to IgM, is presented. Passive transfer (PT) activity was manifested in cryoglobulin-free serum and in up to 20-fold dilutions of fraction I, the IgM-containing fraction obtained by Sephadex G-200 column chromatography. PT test results were positive with serum absorbed with cold agglutinins, and with heat-treated (56 degrees C, 4 hr) serum. These results were negative with cryoglobulin and after absorbing the supernatant of fraction I with anti-IgM. Skin adhesion time was within 24 hr. The in vivo histamine release during cold stimulation was recorded and in this patient, antihistamine administration proved the best method to alleviate the symptoms.
While the standard physiological and even certain psychological characteristics of asthmatic patients are well known, the current diagnostic and therapeutic approach to asthma remains inadequate, as it neglects certain interrelated somatopsychic factors vital to an optimal diagnostic-therapeutic programme. These include the role of skeletal muscle tension and posture, the role of the 'voluntary' respiratory musculature, especially the diaphragm, as well as anxiety, emotional suppression and excessive self-consciousness, all of which may be precipitants rather than the outcome of the onset of asthma. On the basis of these neglected factors and others, implications for an optimally effective therapy are discussed. The physical medicine or physiotherapeutic, as well as other recent therapeutic approaches, are reviewed and evaluated. It is concluded that all of these therapies are too "specific," and that a more holistic approach is necessary (which is provided in 'Asthma: The Yoga Perspective,' Part II-"Yoga Therapy in the Treatment of Asthma").
The fine structural localization of ChAc activity was studied in the rat neostriatum by a ultracytochemical method. The reaction products of ChAc activity were seen in the cisternal structures and plasma membrane of some medium-sized neurons. Some boutons with ChAc-positive vesicles were observed to make an axo-dendritic or axo-somatic symmetrical synapse.
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