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Biomedical subjects

Xiaodong Tao

Publications and source records attributed to Xiaodong Tao.

2 recordsLinked to original sources

Hierarchical active shape models, using the wavelet transform.

Active shape models (ASMs) are often limited by the inability of relatively few eigenvectors to capture the full range of biological shape variability. This paper presents a method that overcomes this limitation, by using a hierarchical formulation of active shape models, using the wavelet transform. The statistical properties of the wavelet transform of a deformable contour are analyzed via principal component analysis, and used as priors in the contour's deformation. Some of these priors reflect relatively global shape characteristics of the object boundaries, whereas, some of them capture local and high-frequency shape characteristics and, thus, serve as local smoothness constraints. This formulation achieves two objectives. First, it is robust when only a limited number of training samples is available. Second, by using local statistics as smoothness constraints, it eliminates the need for adopting ad hoc physical models, such as elasticity or other smoothness models, which do not necessarily reflect true biological variability. Examples on magnetic resonance images of the corpus callosum and hand contours demonstrate that good and fully automated segmentations can be achieved, even with as few as five training samples.

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Using a statistical shape model to extract sulcal curves on the outer cortex of the human brain.

A method for automated segmentation of major cortical sulci on the outer brain boundary is presented, with emphasis on automatically determining point correspondence and on labeling cortical regions. The method is formulated in a general optimization framework defined on the unit sphere, which serves as parametric domain for convoluted surfaces of spherical topology. A statistical shape model, which includes a network of deformable curves on the unit sphere, seeks geometric features such as high curvature regions and labels such features via a deformation process that is confined within a spherical map of the outer brain boundary. The limitations of the customary spherical coordinate system, which include discontinuities at the poles and nonuniform sampling, are overcome by defining the statistical prior of shape variation in terms of projections of landmark points onto corresponding tangent planes of the sphere. The method is tested against and shown to be as accurate as manually defined segmentations.

Algorithms↗