[Mitral valve prosthesis implantation complication: thrombosis].
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Adult↗
Biomedical subjects
X Xu
Publications and source records attributed to X Xu.
[Total cavo-pulmonary connection for complex congenital heart disease].
Between April 1994 and January 1997, 10 patients with complex congenital heart disease were treated with total cavo-pulmonary connection(TCPC). They included 7 males and 3 females, aged 2-17 years(mean 10.1 years). These cases were single ventricle in 5, tricuspid atresia in 4, severe Ebstein anomaly in 1. For construction of the right atrial lateral tunnel, Gore-Tex patch was used in 9 cases and autologous right atrial wall in another, 4 of the 10 patients underwent TCPC without aortic crossclamping. There were no operative deaths. The follow-up is 2-36 months(mean 12.3 months). All of these patients did well and were in NYHA class I. The advantages, operative indication and technique of TCPC and the experience of improvement of surgical results are briefly discussed in this paper.
Adolescent↗
[Application of pectoralis major myocutaneous flap in the reconstruction of tongue: an analysis of 86 cases].
OBJECTIVE: To analyze the results of the use of pectoralis major myocutaneous (PMM) flap in the reconstruction of tongue. METHODS: From 1984 to 1995, PMM flap was applied in 86 cases with cancer of tongue after radical resection for the immediate reconstruction of the lingual defect. RESULTS: Notwithstanding the advanced lesions in stages T3 and T4, patients had good survival and functional results. The 1-, 3- and 5-year survival rate was 86.0%, 51.2% and 23.3%, respectively. There was complete flap necrosis in one case and partial necrosis in fifteen cases, but the latter spontaneously regressed. The swallowing and speech rehabilitations following surgical treatment for tongue cancer were acceptable, considering the advanced disease status. CONCLUSION: The PMM flap with its abundant tissue and excellent blood supply and anatomic proximity provides a reliable method of primary reconstruction of the substance of the tongue. The surgical procedure is simple, easy to perform. Reconstruction of the tongue with PMM flap meets the clinical requirements in the shape, communication and swallowing rehabilitations. The PMM flap is a reliable material for the reconstruction of tongue with major defect following subtotal glossectomy.
Adult↗
[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues].
OBJECTIVE: To investigate and compare mRNA expression levels of the major human HSPs (including HSP90 alpha, HSP90 beta, HSP70, HSC70 and HSP27) in 25 cases of laryngeal carcinomas and normal controls. METHODS: mRNA slot blot hybridization technique was used and cDNA probes of HSP27, HSC70 and HSP90 beta were prepared with PCR method. RESULTS: HSP90 alpha and HSP70 expression was significantly enhanced approximately 5 fold in laryngeal cancer tissues compared to that in the normal larynx tissues while HSP27, HSC70 and HSP90 beta expression was at similar levels. CONCLUSION: The results suggest that HSP90 alpha and HSP70 may play more important role in the carcinogenic process of laryngeal cancer. To find out mechanisms involved will pave the way for the application of HSPs on the biologic therapy of laryngeal cancer.
Adult↗
[Arterial infusion chemotherapy for patients with advanced and moderately advanced cancer of urinary bladder].
OBJECTIVE: To study the effect of arterial infusion chemotherapy in patients with carcinoma of urinary bladder. METHODS: Eleven patients with advanced or moderately advanced cancer of the urinary bladder (10 transitional cell carcinoma, 1 squamous-cell carcinoma) who were for various reasons not suitable for surgical treatment were treated by arterial infusion chemotherapy according to Seldinger's percutaneous approach. RESULTS: The treatment results were satisfactory with an overall response rate of 90.9% (CR = 2, PR = 8). The average survival time of the 11 patients was 26.2 +/- 13.1 months. The 1-year survival rate was 81.8%. Side effects were mild. CONCLUSION: Arterial infusion chemotherapy is of use in patients with advanced or moderately advanced bladder cancer.
Aged↗
[Radiotherapy combined with intervention treatment for patients with advanced cancer: a randomized study in 60 cases].
OBJECTIVE: To study methods of treatment for advanced cancers. METHODS: From January 1996 to March 1997, 60 patients with advanced cancers whose life expectancy was 3-6 months were randomly divided into two groups. The method of radiotherapy was the same in the two groups, with a dose of DT50Gy/25f/5wk for intra-abdomanal cancers while DT60Gy/30f/6wk for those in the other regions. In the combination treatment group, in addition to radiation, interventional therapy with chemotherapeutic drugs, biological response modifiers or Chinese medicinal herbs was employed. RESULTS: The response rate, mean remission period, median survival time and 1-year survival rate in the combination treatment group was 98.3%, 7.4 months, 11 months and 46.7%, respectively. All these were significantly different from those in the group of patients treated with radiation alone. (63.6%, 4.7 months, 6.5 months and 6.7%, respectively, P < 0.01). CONCLUSION: Radiotherapy combined with intervention treatment can prolong the survival time and improve quality of life in patients with advanced cancer.
Adult↗
Selective superior mesentery arteriography and guide wire as an intraoperative locating mark in small intestine resection for arteriovenous malformations.
OBJECTIVE: To investigate the effectiveness of selective superior mesentery arteriography and a guide wire as an intraoperative locating mark on diagnosing, locating the bleeding sites in the small intestines caused by arteriovenous malformations (AVMs). METHODS: The selective superior mesentery arteriography was done in seven patients with AVMs of the intestines, and a segment of guide wire was placed simultaneously as a locating mark. RESULTS: All the resected intestines were marked by sutures for pathological examination and confirmed as AVMs of the small intestines. The patients were followed up for an average of 25 months (17-35 months). During this period, all patients had no recurrence of hemorrhage. CONCLUSION: The selective superior mesentery arteriography and placement of a guide wire as an intraoperative locating mark in AVMs of the intestines can help surgeons successfully in finding and resecting the lesions without complications. It is a new method and has a perspective to be widely spread.
Adult↗
[Acute epiglottitis in adults with reports 67 cases].
To further understanding of acute epiglottitis in adults, clinical observation was made in 67 adult patients with acute epiglottitis, all of them have pharyngodynia, and 53 cases of them have dysphagia. The mucosa of their epiglottic-glossal surface have both congestion and edema in different degrees, so that there is airway obstruction and dyspnea. The main treatment is antiinfection and keeping tract respiratory free and through, or building up an artificial airway if necessary. In the case of complication--epiglottic abscess, incision and drainage must be made.
Acute Disease↗
[Clinical observation of seventeen cases of carcinoma of the external auditory canal and middle ear].
The clinical observation of 17 cases with carcinoma of the external auditory canal and middle ear revealed that no other factors can affect the prognosis greatly except the death caused by recurrence of primary focus. Because operations would destroy the local anatomic structure and in most cases it is difficult to excise widely aggressive tumors perfectly, the author suggests that the auditory canals should be excised or extended mastoidotympanectomy with radiotherapy after operation be performed for the tumors limited to external canal or middle ear. Radiotherapy before operation can be conducted before extended mastoidotympanectomy or subtotal temporal bone resection for the cases with tumors beyond the middle ear. For the cases with tumors largely beyond the middle ear mastoidotomy can be performed before thorough radiotherapy.
Adenocarcinoma↗
[Cloning of human papillomavirus type 16 E7 gene and expression in E. coli].
OBJECTIVE: To study the biological activity of the E7 gene of human papillomavirus 16 (HPV16). METHODS: E7 gene from the cervical carcinoma of Chinese women was amplified by the PCR. The E7 DNA was sequenced and compared with the prototype E7 gene of HPV 16. RESULTS: It showed no mutations. However when E7 gene was inserted into the prokaryotic expression vector pGEX-2T and the fused E7 protein was efficiently expressed in E. Coli (DH5 alpha). The E7 antibody could combine specifically with this fused protein by Western blot technique. CONCLUSIONS: The result might aid for epidemiological investigation and preparation of the vaccine.
Base Sequence↗
[Changes of the deformability of neutrophil and the influence of anisodamine on neutrophil deformability during endotoxin-induced acute lung injury in rats].
OBJECTIVE: To explore the mechanisms of change of deformability of polymorphonuclear leukocytes (PMN) and influence of anisodamine on deformability of PMN during endotoxin-induced acute lung injury (ALI) in rat. To explore the role of PMN in ALI. METHOD: The model of ALI in rat was reproduced by intravenous injection of E Coli endotoxin. The deformability of PMN was measured by micropipette aspiration technique. RESULT: The elastic modulus K1 of PMN at the 1st hour (33 +/- 12 Pa), 4th hours (37 +/- 12 Pa, 1 Pa = 0.0075 mmHg) and 6th hours (38 +/- 13 Pa) after injection of E Coli endotoxin are all significantly higher than that in the control group (26 +/- 9 Pa P < 0.01). The viscosity modulus (mu) of PMN at the 4th hours (5 +/- 3 Pa.s) and 6th hours (6 +/- 3 Pa.s) after injection of E Coli endotoxin are all significantly higher than the control group (3.1 +/- 2.6 Pa.s, P < 0.01). The elastic shear modulus (G) of PMN at the 4th hours (54 +/- 20 Pa) and the 6th hours (56 +/- 21 Pa) after injection of E Coli endotoxin are all significantly higher than the control group (47 +/- 17 Pa, P < 0.05). The K1(33 +/- 12 Pa) and mu(4 +/- 3 Pa.s) in anisodamine group are all significantly lower than endotoxin group in the same time phases (P < 0.05). CONCLUSION: The deformability of PMN decrease remarkably during ALI, which will enhance PMN sequestration in lungs, lead to ALI. It may be one of important pathogenic mechanism of ALI. The anisodamine can inhibit the decrease of deformability of PMN effectively and may have some therapeutic effect on ALI.
Animals↗
[Culture of mycobacterium tuberculosis of gastric juice collected through different ways in diagnosis of pulmonary tuberculosis in children].
OBJECTIVE: To explore the value of culture of Mycobacterium tuberculosis through gastric juice specimens in diagnosis of patients with pulmonary tuberculosis in children. METHOD: Sputum, early morning vomited gastric juice (MVG), the other time vomited gastric juice (OVG) and early morning gastric lavage (MGL) were collected from 46 children with suspected pulmonary tuberculosis. All the specimens were processed to culture for Mycobacterium tuberculosis using pyruvate media, and the results were compared. RESULT: Of the 46 cases, Mycobacterium tuberculosis was found in 4 sputum samples (9%), 15 MGL samples (33%), 12 MVG samples (26%) and 2 OVG samples (4%). CONCLUSION: Collecting gastric juice through different methods for culture of Mycobacterium tuberculosis is specific for diagnosis of paediatric pulmonary tuberculosis.
Adolescent↗
[Progress in the study of antineoplastic activity of suphora flarescens ait and its alkaloids].
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Alkaloids↗
[Enantioseparation of chlorpheniramine and EMD-56431 by micellar electrokinetic capillary chromatography using deoxycholate salt and beta-cyclodextrin].
Two chiral drugs of EMD-56431 and chlorpheniramine are separated by cyclodextrin-modified micellar electrokinetic capillary chromatography using beta-cyclodextrin(beta-CD) and sodium deoxycholate(SDC) as selector in the paper. All the electrolytes in experiments contain 0.1 mol/L borate. The length of capillary is 45.0 cm as total and 30.0 cm as effective. The running and loading voltages are all 7.8 kV. The effects of pH and concentrations of SDC and beta-CD are studied, in which the best chiral separation conditions for EMD-56431 are pH 10.4, [beta-CD] = 50 mmol/L, [SDC] = 150 mmol/L, and those for chlorpheniramine are pH 9.0, [beta-CD] = 50 mmol/L, [SDC] = 100 mmol/L. The mechanism of chiral separation for the buffer system is initially believed as: the micellar monomer exists almost all as inclusion body with beta-CD, some CD-SDC inclusion complex may exist in micellar because the SDC micellar's gather number is only 4 and the SDC molecular is so big that it can only partly enter beta-CD. Then, the good separation ability of the system is supplied while the ratio of concentration between SDC and beta-CD is in 4:1-4:3; but there will be a optimized total concentration for SDC and beta-CD. The complex interaction among sample, SDC and beta-CD makes intricate change for migration along with the selector's concentration, and the same complex results are also made in pH experiments because of electroosmosis and the acidity of SDC and components. The phenomenon of increasing beta-CD solubility is showed. The beta-CD's solubility with 100 mmol/L SDC can be increased above 150 mmol/L.
Benzopyrans↗
[Chemical constituents of essential oil from roots and rhizomes of Valeriana alernifolia Bunge].
OBJECTIVE: To study the chemical constituents of essential oil from the root and rhizome of Valeriana alternifolia. METHOD: The essential oil was extracted by steam distillation. The components were separated and identified by gas chromatography-mass spectrometry and elucidated on the standard mass spectral data and the percentages were determined by gas chromatographic area normalization method. RESULT: Twenty-eight constituents were identified, which make up 64.05% of the oil. CONCLUSION: Bornyl acetate is the main constituent, and other constituents include borneol, terpinyl acetate, alpha-curcumene, camphene, isovaleric acid, trans-beta-farnesene, beta-bisabolene, etc.
Camphanes↗
[Expression of heat shock proteins in laryngeal carcinoma].
OBJECTIVE: To determine the expression of HSPs(HSP90 alpha, HSP90 beta, HSP70, HSP27) in laryngeal carcinoma and normal laryngeal mucosa. METHODS: Total RNA were extracted from 21 laryngeal cancer tissue samples and the normal mucosa of the corresponding larynx. The expression of HSPs mRNA was examined by Slot blot analysis. RESULTS: 1. HSP90 alpha and HSP70 were selectively overexpressed 5 times more in laryngeal carcinoma than in normal mucosa of larynx. 2. HSP90 beta and HSP27 were constitutively expressed at low level in these two groups. There was no significant difference between the levels of expression of HSP90 beta and HSP27 in laryngeal carcinoma and normal controls. CONCLUSION: The results that HSP90 alpha and HSP 70 mRNA were selectively overexpressed in laryngeal carcinoma suggested that HSP90 alpha and HSP70 might play a specific role in the pathogenesis of laryngeal cancer. To clarify the mechanism of HSPs action could help to provide theorical basis for the biological therapy of laryngeal cancer.
Adult↗
[Treating early giant retinal tears altogether with perfluorodecalin and perfluoropropane].
OBJECTIVE: To study the method of lens-sparing (without lensectomy) and non-silicone oil tamponade for treating early giant retinal tears. METHOD: 13 early giant retinal tear cases were treated altogether with perfluoropropane and perfluorodecalin. RESULTS: The retinal reattachment rate was 92.3% and the visual acuity was obviously improved. CONCLUSION: The lens-sparing and non-silicone oil tamponade treatment of early retinal tears altogether with perfluorodecalin and perfluoropropane is helpful to improve the success rate of the retinal detachment surgery and the visual acuity outcomes.
Adult↗
[An immunohistochemical study of basic fibroblast growth factor in early acute myocardial ischemia].
With the use of immunohistochemistry, the expression of basic fibroblast growth factor (bFGF) in early acute myocardial ischemia of rats was studied. It was observed that there was an initial (30 min) rise in bFGF expression in limited ischemic myocardium areas and perimyocardial ischemia areas. The grade of expression of bFGF increased with the continuation of ischemia. The results of image analysis and statistical process suggested that the expression of bFGF reach a high level in ischemic myocardial areas after three hour's of ischemia, significantly higher than in control group and in group B1, but no significant difference in pericardial ischemia areas and normal areas of the same group. In summary, early acute myocardial ischemia is accompanied by rapid and prolonged increase in expression of bFGF with characteristic spatial and temporal kinetic. This finding suggests that the immunohistochemical staining of bFGF provide objective morphologic evidence for the diagnosis of early myocardial ischemia.
Animals↗