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Biomedical subjects

X T Li

Publications and source records attributed to X T Li.

42 records · Page 3Linked to original sources
PubMed1983

Effect of AT1727 on growth and metastasis of murine tumours.

AT1727 was tested on 5 different murine tumour systems. Compared with its analogue, razoxane, AT1727 was less effective at multiple low doses against sarcoma 180 and L1210 leukaemia. A single high-dose treatment with AT1727 was, however, more active than razoxane. AT1727 inhibited the growth of the Lewis lung primary tumour and significantly reduced the number of pulmonary metastases. Although AT1727 showed a slight inhibitory effect on the growth of the B16 primary, it had no effect on the metastases.

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PubMedDate not supplied

Effect of RA233 alone and combined with radiation on experimental tumour metastasis. Part 1.

The effect of the platelet aggregation inhibitor RA233 alone or in combination with radiation was investigated on the spontaneously metastasizing B16 melanoma and on the Lewis lung carcinoma. The effect of this, agent on intravenously injected cells from these tumours was also studied. When single viable 3LL or B16 melanoma cells were injected intravenously, RA233 significantly increased the number of 3LL lung colonies but decreased significantly the B16 lung colonies. RA233 alone did not influence the number of pulmonary metastases arising spontaneously from the B16 or 3LL tumours either with the primary in situ or following excision. When lungs were irradiated before implantation of the 3LL an increase in the number of metastases resulted. This increase was unaffected by RA233 administration. When the primary B16 was irradiated 14 days after implantation and excised 7 days later, a significant decrease in numbers and distribution of metastases resulted in animals treated with RA233. This was accompanied by a considerable increase in long-term survivors.

Animals↗
PubMedDate not supplied

Antitumor effect of RA233 alone and combined with radiotherapy.

The effect of RA233 alone or in combination with radiation was investigated in vivo on the S180 sarcoma, the B16 melanoma and the Lewis lung carcinoma. The combined treatment was a significant improvement over radiation alone for the B16 and S180 tumours. RA233 alone did not influence the growth of these tumours. When the primary 3LL was irradiated, tumour size was unaffected but the number of pulmonary metastases was reduced. They were further reduced by the combination of RA233 and radiation. The number, volume and cytokinetics of the B16 cells and the 3LL cells were affected to varying degrees by RA233. The significance of these changes relative to the effects of RA233 are discussed.

Animals↗