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Biomedical subjects

X Pan

Publications and source records attributed to X Pan.

At least 181 records · Page 10Linked to original sources
PubMed1992

[Pharmacokinetics of sinomenine by HPLC].

Pharmacokinetics of sinomenine in rabbit was studied by reverse-phase HPLC method. After i.v. injection of 20 mg/kg of sinomenine to rabbits, the pharmacokinetic characteristics were found to fit a two-compartment open model.

Animals↗
PubMed1991

[Detection of steroid 21-hydroxylase gene variation among normal Chinese and patients with congenital adrenal hyperplasia].

Genomic DNA from 40 unrelated healthy individuals and 16 families affected with 21-hydroxylase deficiency were digested with restriction enzyme Taq I followed by Southern blot and hybridization using a 21-hydroxylase (21-OH) gene cDNA probe. In healthy individuals the number of copies of 21-OHB gene was constant while that of 21-OHA gene was variable including deletion and duplication. In addition, we found an extra 5.6 kb band in one normal person and in one CAH family. Among the 16 affected families, 19% of 21-OHB gene were deleted. No homologous deletion was found. The frequency of deletion is lower than that reported in the literature. There was variation in the copy-number of 21-OHA gene among patients with CAH, yet no difference was found between the patients and normal persons. The information on prenatal diagnosis of CAH is briefly discussed.

Adrenal Hyperplasia, Congenital↗
PubMed1991

[Evaluation of a logistic regression model in predicting the prognosis of Graves' disease treated by antithyroid drugs].

One hundred and twelve new cases of Graves' disease were treated by tapazole for 6 months and followed up for another 12 months. The initial dose was 30 mg/d. Clinical and biochemical euthyroidism was achieved within 1 to 3 months, then a maintenance was given until cessation of drugs at 6 months. One hundred and eleven cases completed the study. Remission and relapse were defined at the end of follow-up for 1 year according to the presence or absence of clinical manifestation of hyperthyroidism and the levels of T3 and T4. The results of the 12-month follow-up showed that 46 of 111 cases were in remission, and the remaining 65 cases suffered relapse. A logistic regression model with 4 variables was established, which included thyroid suppression rate and goitre size by palpation at the end of drug treatment, the level of T3 before therapy, and the patients' age. The model had 81.5% sensitivity, 84.8% specificity and 82.9% (92/111) accuracy in predicting the outcome of Graves' disease after withdrawal of drug for 1 year. The results were much better than any other univariate analysis in this study.

Adolescent↗
PubMed1990

[Investigation on the distribution and serotyping of V. parahaemolyticus isolated from marine products and environment in Zhoushan archipelago].

Isolation for V. parahaemolyticus from 1003 samples of marine products and environment was attempted in Zhoushan archipelago in 1986-1987. The results showed that V. parahaemolyticus could be detected from all kinds of marine products, the positive rate was between 40%-100%. The V. parahaemolyticus was detected in all samples from the environment. The main O groups were O2, O5, O1, O4, O3 and O12, the O9 groups was not detected. Although 103 serotypes have been detected, the main serotypes were O1K32, O5K17, O5K15, O2K28, O2K3 and O12K51(52), 17.9% of the strains could not be typed.

Animals↗
PubMed1989

Identification of aortic thrombus by magnetic resonance imaging.

The unique properties of magnetic resonance imaging result in the potential to differentiate various components of the diseased arterial wall. In this article four cases are presented in which magnetic resonance imaging showed mural aortic thrombus and its anatomic relationship to the visceral and renal arteries. Once thrombus is identified and localized specific operative strategies can be undertaken to prevent recurrent embolic events and/or avoid perioperative thromboembolic complications.

Aged↗