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Biomedical subjects

X Moreau

Publications and source records attributed to X Moreau.

43 records · Page 3Linked to original sources
PubMed1983

Thymoma and lupus erythematosus. Report of 3 cases.

This paper reports three cases of lupus erythematosus (LE) associated with thymomas, all of which were discovered after the onset of LE. The diagnosis of LE was established by clinical and laboratory data. Histologically, the thymomas were of the three main types: epithelial, lympho-epithelial, and predominantly fusiform. In two cases, thymectomy did not modify the course of LE; in one vase, the absence of cytoplasmic secretory vesicles in the epithelial cells and the non-labelling of these cells by an antiserum thymic factor monoclonal antibody represented direct evidence of a functional thymus deficiency. Antikeratin antibodies were used to distinguish thymomas from lymphomas; epithelial thymomas exhibited the same keratin specificities as normal thymus, although the labelling pattern (net-like) was different. Labelling of epidermis with the same antiserum confirmed the theory of an epidermis-thymus relationship.

Aged↗
PubMedDate not supplied

[Pharmacokinetics of paracetamol in the cerebrospinal fluid in the elderly].

We investigated acetaminophen pharmacokinetics in CSF in twelve operated arteritics patients with continuous spinal anesthesia. Nine men and three women aged 77 +/- 7 years and weighing 66 +/- 15 kg entered in the study after expressing verbal informed consent. They received intravenously a single dose of acetominophen (equivalent to 1 g). Fifteen minutes to six hours after the intravenous injection, blood and CSF samples were withdrawn every thirty minutes, except during the second to the third hour were it was every fifteen minutes. Acetaminophen concentrations in blood and in CSF were assayed by HPLC. Acetaminophen was detected in the earliest samples (1.32 +/- 1.32 micrograms.ml-1) and then increased up to 8.16 +/- 3.04 micrograms.ml-1 at 186 +/- 56 minutes. From 135th to 345th minute, acetaminophen concentration in CSF stay at about 6 micrograms.ml-1, which is the duration of its maximal analgesic central effect.

Acetaminophen↗