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Biomedical subjects

X Mariette

Publications and source records attributed to X Mariette.

104 records · Page 6Linked to original sources
PubMed1989

Morphologic heterogeneity and plasmablastic transformation in advanced plasmacytic/plasmablastic myeloma: a study of 35 serial bone marrow biopsies in 9 patients.

Thirty-five bone marrow biopsies were performed in 9 patients with plasmacytic/plasmablastic myeloma stage IIIA of the Durie and Salmon classification. The cytologic and/or histologic transformation observed in the serial bone marrow biopsy specimens of 3 patients reflected an aggravation of the disease, and was expressed as an increase of bone marrow plasmablasts associated with a gradual decrease or even disappearance of the plasmacytic component. Beyond 50% of bone marrow plasmablasts, the plasmablastic myeloma represented a more aggressive phase in the course of the disease. In 2 patients this transformation was manifested by the development of extramedullary lesions. The possibility of chemotherapy influencing the progression of the plasmablastic clone by destroying the initial plasmacytic clone cannot be ruled out. These results are not devoid of therapeutic implications. They also emphasize the need for serial bone marrow biopsies for better detection of transformation into a less favorable cytologic and/or histologic type of myeloma.

Blast Crisis↗
PubMed1989

Rectus femoris sheath: a new localization of hip synovial cyst.

Iliopsoas bursitis is the classical manifestation of synovial cysts of the hip. We report the first observation of a new localization of these cysts: the sheath of rectus femoris muscle. The patient presented with a hip osteoarthritis and an important mass of the front of the thigh. Computed tomography was useful in establishing the diagnosis and hip arthrography confirmed the communication between the joint and the rectus femoris sheath.

Arthrography↗
PubMed1988

[Antibody activity of monoclonal immunoglobulins].

Monoclonal immunoglobulins present a normal structure and have an antibody activity. This activity may be directed against exo-antigens especially bacterial, but more frequently against auto-antigens. It may then be symptomatic and therefore explain unusual clinical or biological manifestations in the course of monoclonal dysglobulinemias; but, most of the time, the monoclonal auto-antibody activity is asymptomatic and polyspecific, as it is only the monoclonal expression of polyclonal natural auto-antibodies. A comprehensive review of the various antibody activities of monoclonal immunoglobulins is presented. With the presence, in large quantities, of monoclonal immunoglobulins and their antibody activity, the links between dysglobulinemia and autoimmune disease are discussed as well as the pathogenic role of auto-antibodies.

Agglutinins↗
PubMed1987

[Paralysis of the posterior branch of the radial nerve caused by a lipoma].

A case of compression of the posterior branch of the radial nerve by a lipoma is reported. This case is unusual because of the large size of the tumor (13 cm x 6 cm) and the interest of CT to exclude a liposarcoma. The risk of liposarcoma is greater with large size tumors. Reported 27 cases have been analyzed. The posterior branch of the radical nerve is particularly vulnerable because of the anatomic relationships. Thus benign extraneural sof-tissue tumors of the extremities may be responsible of nerves compressions.

Aged↗
PubMed1987

[Multicentric reticulohistiocytosis. A case with unusual clinical, radiologic and ultrastructural aspects].

We are reporting a case of multicentric reticulo-histiocytosis which is exceptional because of its gravity and the diversity of the clinical lesions: huge subcutaneous nodules, bone destruction in the spine responsible for spondylolisthesis, pulmonary fibrosis, acute pericarditis, laryngeal compression requiring a permanent tracheostomy. From ultrastructural observations, various hypotheses to explain the intra-macrophagic accumulation of membrane granules and lipids are discussed.

Arthritis↗
PubMedDate not supplied

Detection of the tax gene of HTLV-I in labial salivary glands from patients with Sjögren's syndrome and other diseases of the oral cavity.

OBJECTIVE: To confirm a possible association between Sjögren's syndrome (SS) and the tax gene of human T lymphotropic virus type I (HTLV-I). METHODS: We studied by PCR labial salivary glands (LSG) from 50 patients with definite SS and from 58 controls including 32 patients with LSG involved by other inflammatory processes and 26 normal LSG. Antibodies to HTLV-I and antibodies to the Tax protein were searched for in serum. RESULTS: We detected the tax gene of HTLV-I in LSG from 15/50 (30%) of patients with SS but also in specimens from 9/32 (28%) patients with LSG involved by other inflammatory processes (3/9 graft-versus-host disease, 5/19 extra-vasated cysts, 1/4 sarcoidosis) and from only 1/26 (4%) normal LSG. A 652 bp region, sequenced in 2 SS patients, was 98-98.5% homologous to the canonic sequence of tax HTLV-I. The HTLV-I gag, pol and env genes were never detected. The serum of the SS patients did not contain antibodies to HTLV-I. However, anti-Tax antibodies were detected in the serum of 18/25 (72%) SS patients, 10/10 (100%) patients positive for tax DNA in their LSG and 8/15 (53%) patients negative for tax DNA in their LSG. CONCLUSION: Our observations raise the possibility that a very low number of copies of the tax gene may be harbored innocuously in cells within the oral cavity in some healthy individuals, but that this gene may play a role as a co-factor in the development of SS or other diseases of oral cavity.

Adult↗