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Biomedical subjects

X Huang

Publications and source records attributed to X Huang.

At least 667 records · Page 37Linked to original sources
PubMed1992

Effects of qingkailing on experimental allergic uveitis in rabbits.

Experimental allergic uveitis (EAU) in rabbits was induced by single intraocular injection of bovine serum albumin (BSA). The average of protein concentration in aqueous humor of untreated group of rabbits was 14.33 +/- 1.21 mg/ml and the count of tritiated thymidine (3H-TdR) incorporated into lymphocyte T was 3,987 +/- 1,156cpm/10(6). The specific antibody responses to BSA in the serum and the aqueous were 0.508 +/- 0.034 and 0.369 +/- 0.019 (OD) respectively. Meanwhile, the effect of Qingkailing on EAU was observed in comparison with dexamethasone as the positive control. The inflammatory reactions of rabbits treated with Qingkailing were remarkably diminished clinically and pathologically. The amount of protein concentration in aqueous of the treated rabbits was 5.79 +/- 2.19 mg/ml (P < 0.01) and the count of 3H-TdR incorporation was 2,455 +/- 981cpm/10(6) (P < 0.05). The responses of antibody in the serum and the aqueous were 0.414 +/- 0.059 and 0.253 +/- 0.041 (P < 0.01) respectively. Our observations indicate that Qingkailing has a positive therapeutic effect on EAU in the rabbits and sustain the suggestion that this drug is capable of suppressing immune and phlogistic reactions.

Animals↗
PubMed1992

[Identification of morphology and inorganic elements of Eucommia ulmoides Oliv. produced in Sichuan by applying scanning electron microscope with energy dispersive X-ray analysis].

A research on the identification of morphology and inorganic elements of Eucommia ulmoides produced in Sichuan has been made by applying scanning electron microscope; energy dispersive X-ray analysis. Qualitative and semi-quantitative analyses of the inorganic elements in the observed areas have been obtained.

Calcium↗
PubMed1992

[Hepatic segmentectomy using microwave tissue coagulator].

Hepatic segmentectomy using a microwave tissue coagulator guided by intraoperative ultrasonography is a new operative procedure, which our research unit was the first to start using from 1990. Up to now we have performed this kind of operation with success in 26 cases. Our results suggested that the new procedure simplified the original operation and greatly reduced the risk of hemorrhage and iatrogenic spread of the cancer cells during operation. Besides, this operation as a kind of definite anatomic hepatectomy can minimally resect the tumor bearing tissue in a radical fashion, while maximally preserve the tumor-free tissue of the liver.

Adult↗
PubMed1992

Mass treatment of filariasis using DEC-medicated salt.

Diethylcarbamazine (DEC)-medicated salt was used to control bancroftian filariasis in 20 endemic counties and cities of Fujian Province in China. The population was 5,189,126 and the microfilaria (mf) rates were between 1.56 and 11.81%. The total dose of DEC was 6-10.5 g per person over a period of 2-4 months. Six to 9 months after treatment the mf rate was reduced to 0-0.57% with a mean of 0.07% (621/823,796). In 184 villages sampled one year post treatment the mf rate was 0.22% (371/171,067) and in 29 villages 2-4 years after treatment the mf rate was 0.05% (31/56,459). In a region of endemic Malayan filariasis, with a population of 67,778 and mf rate of 3.82-4.36%, treatment with DEC-medicated salt to a dosage of 3.2 g DEC per person was administered for 2 months. Six months after treatment the mean mf rate was reduced from 4.08 to 0.26% (10/3841). Filariasis in all the villages controlled with DEC-medicated salt reached the basic criteria of elimination (mf rate below 1%).

Animals↗
PubMed1992

Xanthogranuloma of the stomach: a case report.

A case of xanthogranuloma of the stomach causing clinical signs and symptoms suggestive of gastric cancer is reported. The pathological findings and the malignant potential of this lesion are discussed.

Aged↗
PubMed1992

Functional influence of interlaminar connections in the hamster's superior colliculus.

The aim of this study was to determine the functional importance of intrinsic connections within the hamster's superior colliculus (SC) in the development of the visual responses of neurons in the deep layers of this nucleus. We used localized injections of lidocaine to block action potentials of fibers that passed through the superficial layers and injections of CoCl2 to block synaptic transmission in these layers. We also determined the morphology of a number of the deep layer cells recorded in these experiments by intracellular injection of HRP. Injection of lidocaine into the superficial layers completely abolished the visual- and/or optic chiasm-evoked responses of all 40 deep layer cells tested. Thus, fibers that either pass through or synapse in the superficial layers are necessary for the visual responses of deep layer neurons. Injections of CoCl2 restricted to the superficial layers significantly reduced the visual responsivity of 86% of 92 deep layer neurons tested and abolished the visual responses of 68% of these cells. Superficial layer injections of CoCl2 were equally effective in reducing the responses of neurons with dendrites that ascended into the superficial layers (all seven cells tested and recovered) and those of cells with dendrites restricted to the deep layers (six of seven cells tested and recovered). Injections of CoCl2 into the deep layers, in the region of the cell being recorded, significantly reduced the visual responses of 59% of 37 cells and abolished the visual responses of 40% of the neurons tested. Deep CoCl2 injections abolished the visual responses of three of four cells with dendrites restricted to the deep layers and only one of four cells with dendrites that ascended into the superficial layers. These results indicate that descending interlaminar axons from visually responsive superficial layer cells may be responsible for the visual responsivity of most neurons in the deep SC layers of hamster. Also, some deep layer neurons in this species may receive effective visual input through their dendrites that ascend into the superficial layers, where they are likely to be contacted by retinal axons or axon collaterals of superficial layer cells.

Animals↗
PubMed1991

A three-dimensional analysis of a bioprosthetic heart valve.

A three-dimensional finite element model of the leaflets of a bicuspid bioprosthetic heart valve is presented. The model is based on a non-linear elastic representation of the tissue behaviour which closely simulates that found in experiments. The geometry of the model is based on measurements from a real valve. Shell elements which permit bending have been used in the analysis. The results indicate that bending stresses in the leaflets make a significant contribution to their deformation. This confirms earlier two-dimensional work which had suggested that analyses, where only membrane stresses were modelled, were likely to produce significant errors in the stress states. The analysis also predicts peak stresses close to, but not at, the attachment of the leaflet to the stent post.

Biomechanical Phenomena↗
PubMed1991

[Consecutive observation of the plasma MDA, XO and UA levels and erythrocyte SOD in 10 cases of cardiopulmonary bypass].

The plasma malonaldehyde (MDA), xanthine oxidase (XO) and uric acid (UA) levels and erythrocyte superoxide dismutase (SOD) were measured in 10 cases during cardiopulmonary bypass (CPB) operation. These examinations were taken at pre-aortic clamping, 15 min after aortic clamping, 30, 60, 120 and 180 min after reperfusion respectively. The results showed that MDA, XO and UA rise but SOD decreases after reperfusion. We believe that a lot of oxygen free radicals (OFR) release during peri-operative period and the XO may be an important pathway of OFR release.

Cardiopulmonary Bypass↗
PubMed1991

[Longitudinal changes of serum specific antibodies in Lewis rats immunized with IRBP].

The serum antibodies specific to either interphotoreceptor retinoid-binding protein (IRBP) or retinal S-antigen were longitudinally determined in Lewis rats immunized with 50 x 10(-6)g of IRBP emulsified with complete Freund's adjuvant. To our knowledge, it is the first time to purify IRBP and to address the experiment with IRBP in China. It was shown that the antibody specific to IRBP appeared on the 7th day, followed by a gradual increase, and reached its peak on the 26th day after immunization. No antibody specific to S-antigen was found. The relation between anti-IRBP antibody and experimental autoimmune uveoretinitis (EAU) which occurred in the increasing phase of the antibody suggests that the humoral immunity may be implicated in the pathogenesis of EAU.

Animals↗
PubMed1990

A two-dimensional finite element analysis of a bioprosthetic heart valve.

A finite element scheme has been developed using total Lagrangian techniques for the two-dimensional analysis of bioprosthetic heart valve leaflets undergoing large deformation. Two models of a leaflet, namely a radial and a circumferential slice, have been analysed. The attachment of the slice to the stent was simulated by progressive contact on a circular former and the coaptation of the leaflets in the centre of a heart valve by a straight line of contact. For the circumferential model, different initial configurations have been considered. The prolapse pressure under which the heart valve closes has been shown to be small in comparison with the normal pressure a heart valve sustains. The regions of the valve that are most heavily stressed are subjected to a strong component of bending. The amount is sensitive to the details of the boundary conditions and to the initial configuration of the valve. These observations are likely to be significant in the use of this kind of stress analysis to improve the design of this type of valve.

Bioprosthesis↗
PubMed1990

[Inhibition of growth and metastases of lung carcinoma in C57BL/6 mice by Corynebacterium parvum and its antitumor mechanism].

Cocrynebacterium parvum (CP) was injected around the tumor and tumor cells were inoculated subcutaneously with activated peritoneal macrophages. The effects on the growth and metastases of Lewis lung carcinoma in C57BL/6 mice were observed. Experimental results indicated that CP had significant inhibitory effect on the tumor growth and lung metastases. The cytotoxic effects of activated peritoneal macrophages in mice on target tumor cells (L5178Y) in vitro were studied with the technique of 3H-TdR assay. The proliferation of tumor cells was markedly inhibited by the activated peritoneal macrophages of CP. Experiments showed that the antitumor mechanism of CP was the mediation via activated cytotoxic macrophages. These results indicated that CP is an effective immunostimulant. These findings will provide a scientific basis for the clinical treatment of the primary and metastatic lung carcinoma.

Adjuvants, Immunologic↗
PubMed1990

[Characterization of the expression of LDH isozymes genes during non-hibernation Himalayan marmots].

The lactate dehydrogenase (LDH) isozymes from heart, liver, kidney and skeletal muscle in Himalayan marmots (Marmota himalayana robusta) in non-hibernation were investigated in the present experiment. The isozyme patterns were analyzed by means of disc electrophoresis and the ultraviolet enzymatic determination. The following conclusions were obtained: 1. It was found that two expression patterns of LDH genes presented in the skeletal muscle of Himalayan marmots. There was a LDH-B4 band only in one marmots and absent in others. The interindividual polymorphism of LDH isozyme patterns may be attribute to one or more regulator genes controlling synthesis of B-subunit of LDH. 2. LDH zymograms of various tissues of Himalayan marmots showed different subbands. This is presumably due to the existence of both symmetrical and asymmetrical conformers of this tetramer.

Animals↗
PubMed1990

[Serum antibodies to bovine retinal S antigen in the patients with uveitis and healthy subjects].

The antibodies to bovine S-Ag in sera were determined by ELISA in 43 patients with acute or chronic, anterior or panuveitis and in 32 healthy persons as controls. The results showed that the antibodies titers to bovine S-Ag in the patients with panuveitis were not different from those in the controls (P greater than 0.05). However the antibody titers to bovine S-Ag in the patients with anterior uveitis were significantly lower than those in the controls (0.01 less than P less than 0.05). It is suggested that there are naturally occurring antibodies to S-Ag in health persons. The relationship between antibodies to S-Ag and uveitis is discussed. It is indicated that natural antibodies to S-Ag may play a protective role in the healthy subjects.

Adolescent↗