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Biomedical subjects

X Guo

Publications and source records attributed to X Guo.

At least 451 records · Page 25Linked to original sources
PubMed1992

Modern surgical treatment of congenital subluxated lenses.

Traditional surgical management of subluxated lenses is usually associated with a high incidence of operative and postoperative complication and a poor visual outcome. We treated a series of 14 patients (26 eyes) whose visual acuity could not be improved with optical correction (phakic or aphakic) with modern microsurgery and automated suction-cutting devices. Preoperative visual acuity ranged from 0.05 to 0.3. Improvement in post-operative visual acuity was documented in all operated eyes, ranging from 0.4 to 1.0 during a follow-up period ranging from 6 to 59 months (medium 43 months). The only complication was a small accidental cut in the pupillary border in three eyes. Other complication did not occur.

Adolescent↗
PubMed1992

Retinoma and phthisis bulbi of retinoblastoma. 1. Clinical and genetic analysis.

Retinoma and phthisis bulbi of retinoblastoma are rare entities found in retinoblastoma patients and their relatives. Eleven cases of phthisis bulbi of retinoblastoma and 9 cases of retinoma were identified from 1966 to 1991 in our center. The clinic data show that retinoma and phthisis bulbi are closely related to the retinoblastoma gene. Enucleation should be carried out as soon as possible without hesitation for the phthisis of eyes with retinoblastoma. Genetic counseling and frequent observation should be paid attention to retinoma patients and their offspring. The mechanism of retinoma developed is discussed. We propose that the diversity of second mutation might be the cause of retinoma.

Adult↗
PubMed1992

The value of hysteroscopy in the diagnosis of infertility and habitual abortion.

Ninety cases of infertility and habitual abortion were analyzed by hysteroscopy between April 1983 and July 1990 in PUMC hospital. Abnormal changes of the uterine cavity were seen in 74.4%. The result of hysterosalpingography corresponded with that of hysteroscopy in 62.5%, and the result of B-ultrasound corresponded to that of hysteroscopy in 52.5%. The diagnosis of adhesion and polyps of the uterine cavity was made accurately by hysteroscopy, and both could be operated under hysteroscopy. After operative removal of the adhesion, an IUD should be put into the uterine cavity for 3 months. In 60 cases operations were performed during or after hysteroscopy. Of the 45 patients followed, 19 achieved pregnancy. Five patients achieved pregnancy after operative removal of the adhesion. It is concluded that hysteroscopy is more important than B-ultrasound and hysterosalpingography in the examination and treatment of infertility.

Abortion, Habitual↗
PubMed1992

Effects of l-stepholidine on tyrosine hydroxylase activity in rat corpus striatum.

l-Stepholidine (SPD) 2.5 and haloperidol (Hal) 1.0 mg.kg-1 ip increased rat striatal L-3,4-dihydroxyphenylalanine (DOPA) and 3,4-dihydroxyphenylacetic acid (DOPAC) accumulation induced by NSD 1015 (50 mg.kg-1, ip), a decarboxylase inhibitor. SPD (2.5 mg.kg-1, ip) did not alter but apomorphine (2.0 mg.kg-1, ip) decreased the dopamine (DA) content elevated by gamma-butyrolactone (GBL, 750 mg.kg-1, ip) in the rat striatum. Ip injection of either SPD 5.0 or Hal 2.5 mg.kg-1 after NSD 1015 50 mg.kg-1 or NSD 1015 plus GBL 750 mg.kg-1 also augmented tyrosine hydroxylase (TH) activity in the rat striatum. These results suggest that SPD produces an antagonistic effect on presynaptic DA receptors.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1992

[Studies on second-degree atrioventricular block during atrial fibrillation].

The degree of AV block after cardioversion in 80 episodes of atrial fibrillation in 61 patients who suffered from atrial fibrillation associated with second-degree AV block was observed. Only in 34 of the 80 episodes the electrocardiogram showed first-degree AV block. The remaining 46 had normal AV conduction. No second-degree block was found. It demonstrates that second-degree AV block during atrial fibrillation is not identical with that in sinus rhythm.

Adult↗
PubMed1992

[Cytological observation on culture of embryo in vitro of Tripterygium hypoglaucum (level.) Hutch].

This paper for the first time reports the embryo culture in vitro of Tripterygium hypoglaucum. Callus, adventitious roots and adventitious protuberances were induced from the cultured embryos in vitro. Multi-buds at the excised embryo tip were also observed at the same time. Cytohistological examination showed (1) callus was histologically easy to be induced to form adventitious roots; (2) callus on the cotyledons was originated from the epidemical and subepidemical cells of the cotyledons, and the adventitious roots were originated from the disperse meristematic tissue or vascular tissue in the callus obtained from cultured excised embryos.

Culture Techniques↗
PubMed1992

Clinical evaluation of 99mTc-MIBI myocardial tomography for detecting coronary artery disease.

To evaluate the clinical efficacy of 99mTc-MIBI myocardial tomography for detecting coronary artery disease, 34 consecutive patients who underwent both 99mTc-MIBI study and coronary arteriography were included in the present study. Ten without and 24 with significant coronary artery disease were documented by coronary arteriography. The overall sensitivity and specificity of 99mTc-MIBI study for detecting coronary artery disease were 91.8% (22/24) and 80.0% (8/10), respectively. In subset studies, 16 of 17 (94.1%) patients with previous myocardial infarction and 6 of 7 (85.7%) patients with significant CAD but without MI were identified as abnormal. Reversible perfusion abnormalities were shown in 4 of 5 patients undergoing both exercise and rest studies. Rest perfusion abnormalities were shown in 2 patients with unstable angina pectoris who underwent only rest study. In conclusion, 99mTc-MIBI myocardial tomography provides a reliable method for detecting coronary artery disease. Rest study has high sensitivity for identifying patients with MI, and exercise/rest study can identify patients with significant CAD but without MI.

Coronary Disease↗
PubMed1991

Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats.

The effects of lappaconitine (LA) and N-deacetyllappaconitine (DLA) on footshock-induced analgesia (FSIA) were studied by the rat tail flick test. Rats subjected to 90 s nonescaping footshock had a significant increase in tail flick latency. Naloxone (4 micrograms, i.c.v.) partially antagonized the FSIA. After 5 consecutive exposures to footshock, rats developed a complete tolerance to the FSIA. The rats tolerant to FSIA showed a cross-tolerance to morphine- but not LA- and DLA-induced analgesia. Administrations of subanalgesic doses of LA and DLA potentiated the FSIA in both intact and adrenalectomized rats.

Aconitine↗
PubMed1991

Studies on monoclonal antibody against recombinant human granulocyte colony-stimulating factor.

Three hybridoma cell lines producing monoclonal antibodies (McAb) against recombinant human granulocyte colony-stimulating factor (rhG-CSF) have been established by fusing mouse myeloma cell line SP2/0 cells with spleen cells from a BALB/c mouse immunized with rhG-CSF. Ascites was obtained from BALB/c mice by injecting the hybridoma cells intraperitoneally. Three McAbs were purified by the caprylic acid-ammonium sulfate method. For each, the IgG subclass, valence and activity, molecular weight, specificity and affinity were determined. The applications of McAbs against rhG-CSF in the clinic and laboratory are discussed.

Animals↗
PubMed1991

[Surgical treatment of advanced laryngeal cancers].

Twenty-seven cases of advanced recurrent laryngeal cancers were treated surgically with satisfactory postoperative 1, 2, 3 and 5 year surviving rates of 76.2%, 68.8%, 53.8% and 57.1% respectively. The surgical procedures and experiences were described. It is believed that surgical extirpation should be considered the best method and the first choice in the management of advanced laryngeal cancers in spite of its poor prognosis, operative difficulties and dangers.

Aged↗
PubMed1991

[A clinical study and analysis of congenital lenticular dislocation (35 cases)].

Thirty-five cases of congenital lenticular dislocation seen in our Center since 1985 have been studied and analyzed clinically. By the survey of pedigrees and examination of these patients, including ocular, systemic, skeletal X-ray, psychocardiogram, and urinary sodium-nitroprusside test, 21 cases were diagnosed as Marfan's syndrome, 6 cases as simple ectopia lentis, 3 cases as Weill-Marchesani's syndrome, 4 cases as aniridia and 1 case as homecys tinuria. We found that the most significant ocular manifestation of congenital lenticular dislocation was reduction in visual acuity. The severity of visual disturbance varied with the types of dislocation and the visual deficiency was closely related to the intermediate-grade (II) dislocation of the lens. Examination of ERG showed normal function in most of the patients. From this, we believe that the major cause of visual reduction in congenital lenticular dislocation is lenticular myopia and astigmatism. There fore, early diagnosis and effective correction of vision should be emphasized to prevent the occurrence of amblyopia.

Amblyopia↗
PubMed1990

Roles of periaqueductal gray and nucleus raphe magnus on analgesia induced by lappaconitine, N-deacetyllappaconitine and morphine.

In the rat tail flick test, ip LA 6 mg/kg, icv DLA 60 micrograms and icv or with morphine 5 micrograms exhibited significant analgesia. But with either LA 40 micrograms or DLA 60 micrograms was inactive. Naloxone (4 micrograms icv) which antagonized morphine analgesia failed to alter the analgesia induced by LA and DLA. Microinjection of DLA 20 micrograms or morphine 5 micrograms into the periaqueductal gray (PAG) or nucleus raphe magnus (NRM) produced markedly analgesic activity. The effects of electrolytic and kainic acid (0.8 micrograms) lesions of the PAG and NRM on the analgesia elicited in the rat from ip LA, icv DLA and morphine were also evaluated. No change in baseline tail flick latency was observed following lesions of the PAG and NRM. But lesions of the PAG and NRM significantly attenuated the analgesia mediated by LA, DLA and morphine. These results suggest that supraspinal sites, especially the PAG and NRM, are involved in the analgesic action induced by LA, DLA and morphine.

Aconitine↗
PubMed1990

[Primary study of iontophoresis of zinc ion in treatment of retinitis pigmentosa].

We report here the preliminary effects of zinc iontophoresis in treatment of 26 Rp patients who had decreased zinc serum level or abnormal ratio of serum copper to zinc. Through more than 20 to 30 times of therapy, the vision of 15.38% eyes increased more than "3 lines", 4% eyes increased more than 5 degrees in the visual field, 13.46% eyes improved in dark adaptation threshold (greater than 1.0), the visual functions of the rest eyes were slightly improved or unimproved. The fundus didn't change before & after treatment. There were no changes of ERG in 8 eyes of 4 cases. In addition, the advantages and disadvantages between Zn iontophoresis and Zn compound taken orally, the improvement of vision by direct electric current therapy, the relationship between the metabolism of Zn element and Vit A and influence of Zn over the mechanism of dark adaptation were also briefly discussed.

Adaptation, Ocular↗