Biomedical subjects
Publications and source records attributed to X Gosset.
The case reported is of Wegener's granulomatosis which responded only temporarily to immunodepressant treatment and complicated by pulmonary aspergillosis. This combination poses a diagnostic since the respiratory manifestation of the two conditions may be confused, and a therapeutic problem because of contradictions in the drugs indicated.
A patient underwent surgery for the first time at the age of ten years for a right-sided adrenal phaeochromocytoma. She underwent a second operation at the age of 27 years, for a contro-lateral localisation. Phaeochromocytomas are rare in the child. They are frequently bilateral, multiple and situated extra-adrenally. They fall within the context of Sipple's syndrome more rarely than in the adult. Treatment of these bilateral forms requires bilateral adrenalectomy in one or two stages, followed by substitute hormone therapy.
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This clinical trial of fenspiride (injectable and sustained-release 80 mg tablet) was carried out on patients selected because their bronchopathy was of a hypersecretory type. Interesting results were observed in 20 out of 37 cases, but they were often delayed. This group of patients included a high proportion of patients with major hypersecretion; the efficacy of fenspiride is often evident, (in 8 out of 11 cases) but it is unpredictable individually. It can be concluded from this trial that a long term treatment with fenspiride, well tolerated, can usefully be tried in patients with predominant signs of bronchial hyperexudation.