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Biomedical subjects

X Fu

Publications and source records attributed to X Fu.

At least 163 records · Page 9Linked to original sources
PubMed1994

Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors. This role was investigated in an orthotopic transplant model of human colon cancer in nude mice using the matrix metalloproteinase inhibitor BB-94 (batimastat). Fragments of human colon carcinoma (1-1.5 mm) were surgically implanted orthotopically on the colon in 40 athymic nu/nu mice. Administration of BB-94 or vehicle (phosphate buffered saline, pH 7.4, containing 0.01% Tween 80) commenced 7 days after tumor implantation (20 animals/group). Animals received 30 mg/kg BB-94 i.p. once daily for the first 60 days and then 3 times weekly. Treatment with BB-94 caused a reduction in the median weight of the primary tumor from 293 mg in the control group to 144 mg in the BB-94 treated group (P < 0.001). BB-94 treatment also reduced the incidence of local and regional invasion, from 12 of 18 mice in the control group (67%) to 7 of 20 mice in the treated group (35%). Six mice in the control group were also found to have metastases in the liver, lung, peritoneum, abdominal wall, or local lymph nodes. Only two mice in the BB-94 group had evidence of metastatic disease, in both cases confined to the abdominal wall. The reduction in tumor progression observed in the BB-94-treated group translated into an improvement in the survival of this group, from a median survival time of 110 days in the control group to a median survival time of 140 days in the treated group (P < 0.01). Treatment with BB-94 was not associated with any obvious toxic effect, and these results suggest that such agents may be effective as adjunctive cancer therapies.

Adenocarcinoma, Mucinous↗
PubMed1994

Nitrergic innervation of rat brain vasculature.

Nitric oxide synthase has been located in the brain, in several neuronal populations which appear in close contact either with the microvasculature or the external surface of extracerebral vessels. These data provide structural support to the pharmacological evidences of the nitric oxide participation in the regulation of vascular tone of brain blood vessels.

Animals↗
PubMed1994

[Repair of the traumata caused by partial laryngectomy].

At present, the wound caused by partial laryngectomy are repaired by using many kinds of tissues in order to avoid infection, granuloma and laryngeal stenosis. It is unclear whether the traumata has to be repaired by transplant tissues or non-repaired traumata will lead to laryngeal dysfunction. This article analyzed 162 patients who received partial laryngectomy from April 1980 to March 1992. These patients had been divided into two groups: repaired group (78 cases) and non-repaired group (84 cases). Repair material used included sternohyoideus fascia (57 cases), thyro-hyoideus fascia (9 cases), throat musculus flap (6 cases), stemocleido-mastoideus fascia (3 cases) and throat flap (3 cases). The result indicated that there were no significant differences in respiration swallow recovery time and so on. So we concluded that non-repaired group has similar curative effect to repaired group and repairing the traumata (especially minor traumata) with the fascia around the traumata is an effective method.

Adult↗
PubMed1994

Interaction of sex steroids and oxytocin on term human myometrial contractile activity in vitro.

OBJECTIVE: To investigate the interactions of progesterone, estradiol (E2), and oxytocin in regulating the contractile activity of term human myometrium in vitro. METHODS: Myometrial tissues from 12 term pregnant women were obtained from the lower uterine segment at elective cesarean and immediately immersed in Hepes buffer with and without progesterone and progesterone plus E2. Oxytocin was freshly dissolved in solutions when the superfusion was started. Muscle biopsies were dissected along the bundles of smooth muscle under a stereomicroscope, and the preparations were mounted in six tissue baths superfused with different hormonal solutions. The isometric tension was recorded during the experimental time. RESULTS: During the 2-hour contraction period, increased frequency (P < .01 for each) and decreased activity area (P < .01 for each) and duration of contractions (P < .01 for each) resulted from superfusion of muscle strips with progesterone plus oxytocin, progesterone plus E2, and a combination of progesterone, E2, and oxytocin, compared to that found with buffer alone. The higher concentration of progesterone (5 micrograms/mL) plus oxytocin and progesterone plus E2 elevated the tonus (P < .05 and P < .01), whereas progesterone in combination with E2 and oxytocin decreased it (P < .05). The lower concentration of progesterone (0.5 microgram/mL) plus E2, or both in conjunction with oxytocin, had no significant effect on tonus as compared with buffer. CONCLUSION: The results suggest that progesterone and E2 have a direct effect on uterine excitability and a regulating influence on the oxytocin sensitivity of term human myometrium.

Adult↗
PubMed1994

Optimal flow rates for retrograde warm cardioplegia.

Retrograde delivery of warm blood cardioplegia may improve nutrient cardioplegic flow beyond coronary obstructions, but may not adequately perfuse the right ventricle and the posterior left ventricle. To determine the optimal flow rate for warm retrograde cardioplegia, we assessed 62 patients undergoing elective coronary artery bypass in two studies. In the low flow study, administration of 50 ml/min (n = 9), 75 ml/min (n = 11), or 100 ml/min (n = 7) was associated with high lactate production and oxygen extraction during cardioplegic administration. At 50 minutes of cardioplegic arrest, the coronary venous effluent pH was low in all groups. In the high flow study, 30 patients all received flow rates of 100, 200, and 300 ml/min in randomized order during the crossclamp period. In addition, five patients received cardioplegia at a rate of 500 ml/min for the duration of the crossclamp period. Administration of 200 ml/min or higher minimized lactate production and maintained coronary venous pH within the physiologic range, but flows of 300 ml/min or higher did not increase oxygen use or reduce lactate or acid production. Patients in the low flow groups had significantly greater myocardial lactate release during cardioplegic infusion and after removal of the crossclamp than the high flow group. Warm retrograde cardioplegia should be delivered at flow rates of at least 200 ml/min during elective coronary artery bypass operations.

Adult↗