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Biomedical subjects

X F Wang

Publications and source records attributed to X F Wang.

At least 145 records · Page 8Linked to original sources
PubMed1991

Expression cloning and characterization of the TGF-beta type III receptor.

The rat TGF-beta type III receptor cDNA has been cloned by overexpression in COS cells. The encoded receptor is an 853 amino acid protein with a large N-terminal extracellular domain containing at least one site for glycosaminoglycan addition, a single hydrophobic transmembrane domain, and a 41 amino acid cytoplasmic tail with no obvious signaling motif. Introduction of the cDNA into COS cells and L6 myoblasts induces expression of a heterogenously glycosylated 280-330 kd protein characteristic of the type III receptor that binds TGF-beta 1 specifically. In L6 myoblasts lacking the endogenous type III receptor, expression of the recombinant receptor leads to an increase in the amount of ligand bound and cross-linked to surface type II TGF-beta receptors. This indicates that the type III receptor may regulate the ligand-binding ability or surface expression of the type II receptor.

Amino Acid Sequence↗
PubMed1991

Biplane transesophageal echocardiography: imaging sections and anatomic segments.

In order to recognize correctly the images of transesophageal echocardiography (TEE), in 410 subjects TEE was performed with uniplane or biplane transducer, and in 7 corpses the cardiac anatomic segments were observed, at various levels and in different directions, 9 transverse and 6 longitudinal views were compared with the corresponding cardiac anatomic segments. Based on this study, the authors reported the levels of segments, insertion depth, anatomic structure identification, image characteristics and clinical application of TEE, and the advantages of biplane TEE are discussed.

Adolescent↗
PubMed1991

The dentate nucleus is a short-latency relay of a primary auditory transmission pathway.

Recordings of unit activity showing 4-6 ms latency responses to a click stimulus provided evidence that the dentate nucleus could function as a short-latency auditory relay. On the basis of these findings, plus fiber fillings from injections of phaseolus leucoagglutinin into the dentate, a new auditory pathway between dorsal and ventral cochlear nuclei, dentate nucleus, and rostral thalamus is proposed. The pathway could provide direct, short-latency transmissions to the motor cortex that bypass the classical auditory receptive cortex.

Acoustic Stimulation↗
PubMed1991

Hydrogen peroxide contrast hepatosonography.

Hydrogen peroxide contrast hepatosonography (HPCH), a new technique, was developed for liver examination. On examination, 5-10 ml of 2-3% hydrogen peroxide was injected into the rectum through a dual-channel rubber tube. When hydrogen peroxide passed through the mucosa into the portal vein, the fast flowing contrast echoes were seen, and the liver parenchyma was covered by enhanced echoes. A total of 297 subjects were examined by HPCH with a successful contrast rate of 95.6%. In normal subjects, dense contrast echoes were visible throughout the liver. But in patients with hepatoma, hemangioma, cyst and abscess, contrast echo defects were noted. We conclude that HPCE is of great value in the differentiation of space-occupying lesions and measurement of portal circulation time and blood flow velocity in spite of its untoward reactions.

Adolescent↗
PubMed1990

Preliminary study of quantification of regurgitant volume in mitral regurgitation by color Doppler echocardiography.

A method for quantification of regurgitant volume in mitral regurgitation (MR) was studied. 31 cases of MR were investigated with color Doppler. The reliability of measuring velocity by Doppler and the influence of pressure gradient on MR were assessed and confirmed by experimental device. The results suggested that the best method in quantification of the regurgitant volume was "calibrating method" (r = 0.99; P less than 0.01), the next to the best was "volume method" (r = 0.74; P less than 0.01), whereas the regurgitant volume evaluated by multiplication of area, velocity and time was far from the actual regurgitant volume (r = 0.47; P greater than 0.05). The velocity of blood flow measured by Doppler is closely correlated to results obtained from experiments (r = 0.69; P less than 0.05). We believe that the ratio of back flow area and average area of left atrium calculated by Helmcke's method reflects the severity of the disease to a certain degree, bu there are many problems unsolved, e.g. the determination of the velocity of blood flow by color Doppler is dependent on the degree of brightness of coloration; the brighter the color, the quicker the speed it represents, whereas the darker coloration speaks for slower speed.

Echocardiography, Doppler↗
PubMed1990

Diagnosis and treatment of retrocaval ureter.

34 cases of retrocaval ureter of our country, including 2 of our hospital, were studied. The embryologic pathology, diagnosis and treatment of the disorder are discussed. The choice of operative methods and 'vena cava supporter' are also described.

Adult↗
PubMed1990

[Effect of fluoroquinolones made in China in the treatment of acute bacillary dysentery. A report of 212 cases].

212 cases of acute bacillary dysentery were treated with enoxacin and norfloxacin, another 15 cases were treated by chujunsheng. The cure rate in enoxacin group was 99.1%, in norfloxacin group 98.04% and in chujunsheng group 63.64%. The isolated pathogens were tested for susceptibility with disk diffusion and MIC determination. The results showed that both enoxacin and norfloxacin are better than gentamycin, ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole. Side effects of enoxacin group and norfloxacin were noted in are 2.7% and 3.0% of the patients respectively. This study suggests that enoxacin and norfloxacin are highly effective, quite convenient for use and have few adverse reactions. They are considered to be drugs of choice for the treatment of acute bacillary dysentery.

Acute Disease↗
PubMed1990

[Protective effect of 2-[p-(dimethylamino) styryl] pyridine methiodide (DSPM) on acute experimental myocardial ischemia].

ip DSPM 5 mg/kg 1 or 4 h before excision of the heart was found to prevent damage to the heart due to global myocardial ischemia. Compared with the controls, the heart rate, coronary resistance, contractile force and edema of the heart were all greatly improved during the 60 min reflow after 25 min of no-flow, especially the heart pretreated with DSPM 4 h prior to excision. In addition, DSPM 1.5, 6 mg/kg markedly reduced the myocardial Ca2+ content measured by isoproterenol in mice. DSPM at higher dosage also lowered the normal myocardial Ca2+ content. These results suggest that DSPM may have a protective effect on myocardial ischemia which might be associated with its calcium antagonistic action.

Animals↗
PubMed1990

Application of two-dimensional echocardiography in location of balloon of the Swan-Ganz catheter.

Two-dimensional echocardiography was used to guide and locate the balloon of Swan-Ganz catheter during catheterization in 43 patients. The echoes of balloon appeared as a series of strong light spots, with a rate of detection of 100%. Under monitoring of two-dimensional echocardiography, the site of balloon and its moving route could be determined. The coincidence of echographic findings and X-ray findings showed that it can be used instead of X-ray monitoring to lessen irradiation during catheterization. The depth of catheter inserted was measured. The differential points between the echoes of balloon and tubing, the terminology of the balloon site in echocardiography and fluoroscopy, its clinical value and limitation are discussed.

Adolescent↗
PubMed1990

Prognostic significance of general immune competence in acute leukemia.

The prognostic significance of lymphocyte transformation rate, E-RFC%, 29 degrees C E-RFC%, serum IgG, IgA, IgM and C3 levels were studied in 286 patients with acute leukemia. In acute lymphoblastic leukemia (ALL), the pretreatment immunological parameters were not related to whether the patients could achieve complete remission (CR), but the patients with E-RFC% greater than 30% before treatment or E-RFC% restored to normal after treatment had a significantly longer survival time. In acute nonlymphocytic leukemia (ANLL), pretreatment LTR and E-RFC% were significantly higher in patients who could achieve CR subsequently, the patients with higher pretreatment levels of LTR, E-RFC% or 29 degrees C E-RFC% survived significantly longer than patients with lower levels of these parameters, and the patients whose LTR could return to normal after treatment had a significantly higher CR rate and longer survival times. Except that the pretreatment IgM level was related to the survival of ANLL patients, serum levels of immunoglobulins and C3 had no prognostic value for both ALL and ANLL. In both ALL and ANLL, the immunological parameters changed significantly when relapse occurred.

Adolescent↗
PubMed1990

Measurement and study of the nose and face and their correlations in the young adult of Han nationality.

The measurement of 13 items in the face and nose of 220 young adults (110 males and 110 females) of the Han nationality between the ages of 18 and 21 years has been done in the Henan Province of China. The means and standard deviations have been obtained, and the significant differences in many items between males and females have been proved. Some items influencing outer nasal shape have been analyzed. The correlations between nose height, nose length, and morphologic facial height and physiognomic facial height have been discussed. The ratio and amount of nasal breadth to facial breadth and nasal breadth to interocular breadth have been compared and analyzed, and the differences among the different races and between the sexes have been explained.

Adolescent↗
PubMed1989

Color Doppler echocardiography, two-dimensional echocardiography and signs in diagnosis of aortic regurgitation.

To assess the diagnostic significance of color Doppler and two-dimensional echocardiography and signs in aortic regurgitation (AR), we studied 48 patients with AR confirmed by color Doppler. On color Doppler, an abnormal diastolic flow originating from the aortic valve was visualized in the left ventricular outflow tract in the 48 cases. The maximal regurgitant jet area was 0.8-23.3 cm2. On two-dimensional echocardiography, the appearance of cardiac chamber and valves did not offer a clue to the existence of AR in 12 patients (25%). On physical examination, diastolic murmur was inaudible in 18 of 45 patients. Peripheral signs of AR were not found in 20 of 45 patients. In slight AR, signs were usually not detected. From the above we are led to conclude that of the patients with AR confirmed by color Doppler echocardiography, only 75% could be detected by two-dimensional echocardiography and about 55% diagnosed by physical examination.

Adolescent↗
PubMed1989

Pulmonary venous flow evaluated by Doppler echocardiography.

In this paper, we report the results of experimental and clinical studies of the pulmonary vein with Doppler echocardiography in 188 cardiac patients and normal controls. 1. The diameter of the right superior pulmonary vein (RSPV): The diameter of the RSPV was 9.8 +/- 0.2 mm in normals and significantly dilated in the groups with passive or active pulmonary hypervolemia and decreased in the group with pulmonary hypovolemia (p less than 0.001). 2. Blood flow velocity of RSPV: The blood flow velocity of the RSPV measured in normal controls by Doppler echocardiography was 35.7 +/- 3.2 cm/s and significantly decreased in the groups with passive pulmonary hypervolemia and pulmonary hypovolemia (19.6 +/- 7.8 cm/s and 25.2 +/- 9.4 cm/s, respectively) and increased in the group with active pulmonary hypervolemia (49.6 +/- 19 cm/s, p less than 0.001). 3. Blood flow of RSPV: Blood flow of the RSPV was 2.3 +/- 1.5 L/m in normals, 3.4 +/- 2.4 L/m in the group with passive pulmonary hypervolemia, 6.2 +/- 2.9 L/m in the group with active pulmonary hypervolemia and 0.7 +/- 0.5 L/m in the group with pulmonary hypovolemia. Blood flow in the active pulmonary hypervolemic group was higher than that in the passive pulmonary hypervolemic group and the hypovolemic group. There was a high correlation between the pulmonary blood flow measured by Fick's method (Qp) and RSPV flow (RSPVF) measured by echocardiography (Qp = 1.96, RSPVF 0.92, r = 0.81, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Preliminary study on crystals of calcium oxalate in 57 Chinese medicines].

This paper reports the results of a study on 57 Chinese medicinal materials, including the distribution of crystals, types of crystal morphology, size or degree of distinctness. Based on the crystal morphology a checking-index diagram has been compiled as foundations for classifying medicinal plants and micro-identifying the tissue powder of medicinal materials.

Calcium Oxalate↗
PubMed1989

Progression to development of lymphoma in the thymus of AKR mice treated neonatally with SL 3-3 virus.

All AKR mice develop thymic lymphoma between 60 and 90 days of age after neonatal treatment with the oncogenic retrovirus SL 3-3. At 40-50 days of age, in the normal-sized thymus of virus-treated mice, cells appear that produce lymphoma when inoculated intrathymically but not when inoculated s.c. These cells are designated as thymus-dependent (TD) lymphoma cells. TD cells progress to cells that form tumors after both intrathymic and s.c. inoculation; these are designated as thymus-independent (TI) lymphoma cells. In this report, we show that the TD and TI cells can be distinguished as two distinct cell populations. Experiments show that the TD cells reside within the immature CD4- CD8- thymocyte population of the virus-treated mice. In addition, we also show that CD4- CD8- thymocytes from SL 3-3 virus-treated mice do not mature in fetal thymic stromal rudiments. Using three-color flow cytometry to trace maturation of CD4- CD8- thymocytes after intrathymic inoculation into irradiated syngeneic hosts, disregulated thymocyte maturation of this population from virus-treated mice is demonstrated. Thus, altered maturation of and the appearance of TD lymphoma cells in, the most immature population of thymocytes appears to be a first step in a multistep process of thymic lymphomagenesis caused by SL 3-3 virus.

Animals↗
PubMed1989

[Estimation of plasma protein C, protein S and antithrombin III in patients with chronic liver diseases and its clinical significance].

The paper reports the results of estimation of plasma protein C (PC), protein S (PS) and antithrombin III (AT III) in 39 normal controls and 70 patients with various chronic liver diseases and concludes that the plasma values of PC, PS and AT III decrease in patients with chronic liver diseases and the decrease seems to be related to the severity of liver diseases.

Adolescent↗
PubMed1989

[Coetsoidin A, a new diterpenoid from Rabdosia coetsoides C. Y. Wu].

From the leaves of Rabdosia coetsoides C. Y. Wu, a new diterpenoid, coetsoidin A (I) was isolated and its structure was established by spectroscopic and X-ray diffraction analysis. It is the first instance of a kaurene type diterpenoid possessing alpha,beta-unsaturated ketone functionality in ring B.

Chemical Phenomena↗