Biomedical subjects

X Chen

Publications and source records attributed to X Chen.

At least 577 records · Page 32Linked to original sources

PubMed2000

[Event-related potentials and suicide behavior in patients with affective disorder].

OBJECTIVE: To investigate P300 and contingent negative variations (CNV) of patients with affective disorder and its clinical significance. METHODS: 39 depressives, 22 maniacs and 33 normal controls were included in this study. Both P300 and CNV were recorded in every subject, using a nicolet spirit instrument. RESULTS: Both depression and mania groups presented prolonged P300-P3b latency and decreased P300-P3 and CNV amplitudes compared with normal controls. Decreased P300 & CNV amplitudes were further related to the history of suicide behavior in the two patient groups. CONCLUSION: The clinical significance of event-related potentials was confirmed in this study, while the biological correlates of suicide behavior need further and intensive study.

Adult↗

PubMed2000

Hepatectomy for huge primary liver cancer: report of 171 patients.

OBJECTIVE: To discuss the safety and feasibility of hepatectomy for huge primary liver cancer (PLC). METHODS: The effect of resection of huge PLC was examined retrospectively. Some problems about resection of huge PLC were discussed. RESULTS: In 171 patients with huge PLC undergoing hepatectomy, 2 (1.2%) died in one month after operation. The 1-, 2-, 3-, 5- and 10-year survival rates of the patients were 66.1%, 42.1%, 32.7%, 12.2% and 2.3%, respectively. The effect of prolonging survival time was significant. CONCLUSION: Hepatectomy for huge PLC is safe, feasible, and effective.

Adolescent↗

PubMed2000

[Dynamic changes in dermal cell cycles, contents of hydroproline and ratios of collagen type I/III in the burned wound].

OBJECTIVE: To study the dynamic changes in the dermal cell cycles contents of hydroproline and ratios of collagen type I/III in the burned wound. METHODS: The dermal cell cycles, contents of hydroproline, ratios of collagen type I/III and pathologic changes were dynamically observed in 48 deep partial burn rats (TBSA 10%), attempting to investigate the process of deep partial burn wound healing. RESULTS: The percentage of S-phase reached the highest point on PBD 10. On PBD21, it was still significantly higher than that of normal group. OHP increased gradually after burn, and peaked on PBD14. On PBD21, the level of OHP was still significantly higher than that of normal group. The ratios of collagen type I/III decreased gradually and significantly lower than those of the normal group after burn. The strips of WBC infiltrating into wound were observed on PBD3, 7 and 10. On PBD 14, a large number of regenerative epidermal cells crept over wound surface. CONCLUSIONS: The inflammation is obvious from PBD3 to PBD10. The proliferation of dermal cell and the synthesis, deposition of new collagen are predominant from PBD10 to PBD14, and the repair of dermis is not complete on PBD21. The proliferation and migration of epidermal cells are major activities from PBD14 to PBD21.

Animals↗

PubMed2000

[Anterior corpectomy combined with cervical spine locking plate for treatment of multilevel cervical spondylotic myelopathy].

OBJECTIVE: To study the value of cervical spine locking plate (CSLP) combined with anterior corpectomy in treating multilevel cervical spondylotic myelopathy (CSM). METHODS: In 55 CSM patients, 36 were male and 19 female, aged on average 51.5 years. The duration of illness was 13 months on average. Pathological segments in 47 patients included two functional segments and in 8 three functional segments. All patients were treated with anterior corpectomy and self-iliac bone graft and CSLP fixation. RESULTS: 51 patients were followed up for 26 months on average. All grafting bones got solid fusion in 12 to 16 weeks postoperatively. Intervertebral spaces were restored after operation. The physiological curve of the cervical spine was good. The effective rate of operation was 94.1% (48/51) and the excellent rate 78.4% (40/51). The JOA score rose from 8.3 points before operation to 14.1 points after operation. CONCLUSIONS: Anterior corpectomy and osteosynthesis of multilevel cervical spondylotic myelopathy are indicated for CSLP fixation. CSLP in the treatment of cervical spine instability is prospective.

Aged↗

PubMed2000

[Expression and significance of AR in osteosarcoma].

OBJECTIVES: To determine the relationship between AR and pathological characteristics of osteosarcoma and to investigate the potential role of AR in the pathogenesis of osteosarcoma. METHODS: AR in the samples of the paraffin embedded tissues from 65 cases of osteosarcoma was immunohistochemically detected by streptavidin/peroxidase (SP) method. The pathology of osteosarcoma was classified and graded according to Liu Zijun's Classification. RESULTS: The positive rate of AR was 50.8% (33/65). The positive particles were distributed in the cytoplasm and nucleus. The positive rate of AR in osteosarcoma with higher grade of cell differentiation was lower than that in the tumor with lower one. There was no significant difference in different pathological type of osteosarcoma. CONCLUSION: AR exists in osteosarcoma and its positive rate is related to the cell differentiation of osteosarcoma.

Bone Neoplasms↗

PubMed2000

[Anomalous junction of pancreaticobiliary duct in congenital bile-duct cystic and cylindrical dilatation].

OBJECTIVE: To study the relationship between anomalous junction of pancreaticobiliary duct (APBD) and congenital bile-duct cystic as well as cylindrical dilatation. METHOD: Cholangiography was performed in 51 patients with bile-duct dilatation. RESULTS: APBD was diagnosed in 43 patients. In 8 patients (72%), the bile duct was drained into the pancreatic duct (B-P) in the cystic group, whereas in 14 patients (78%), the pancreatic duct was drained into the bile duct (P-B) in cylindrical group. There were significant differences in the internal diameter of the distal bile duct (P < 0.01), the maximal diameter of the pancreatic duct (P < 0.05) and the average angle of pancreaticobiliary junction (P < 0.01) in cystic and cylindrical groups. CONCLUSIONS: Different types of APBD after lead to different pathological changes of the biliary tract. The narrowed distal bile duct joins the pancreatic duct at a right angle in most cystic cases and the pancreatic duct joins the bile duct at an acute angle in most cylindrical cases.

Bile Duct Diseases↗

PubMed2000

[Adjustable interatrial communication in management of severe congenital heart disease].

OBJECTIVE: To assess the use of adjustable interatrial communication in patient with severe congenital heart disease undergoing open heart surgery. METHODS: From February 1998 to June 1999, 13 patients with severe and complex congenital heart disease underwent open heart surgery. Seven patients underwent total cavopulmonary connection, five patients repair of Ebstein's anomaly, and one patient right atrial-pulmonary connection. Adjustable interatrial communication was made in all patients. Four patients had the communication closed at the time of operation, 4 patients had the communication opened at the time of operation, and 5 patients had the communication adjusted and closed postoperatively. RESULTS: All patients had a smooth postoperative process. There were no postoperative death and no severe postoperative complications. CONCLUSION: Adjustable interatrial communication for the patients undergoing modified Fontan procedure or correction of Ebstein's anomaly may be advantageous.

Adolescent↗

PubMed2000

[Craniovertebral decompression and posterior fossa reconstruction treatment of Chiari syringomyelia complex].

OBJECTIVE: To study the results of Chiari malformation/syringomyelia (CM-SM) complex treated by craniovertebral decompression and posterior fossa reconstruction (PFR). METHODS: 37 patients of CM-SM complex were treated surgically from 1994 to 1999. All patients underwent craniovertebral decompression and posterior fossa reconstruction. The procedure consisted of suboccipital craniectomy and laminectomy of C1 (when necessary C2), exploration and plugging of the obex, and resection of arachnoid adherence. A wide dural graft was used to reconstruct the cisterna magna artificially. Syrinx shunt was not performed. RESULTS: Follow-up for 0.5 to 4.5 years showed that 31 patients (83.8%) had their symptoms improved, 5 (13.5%) stabilized, but 1 (2.7%) deteriorated. Magnetic resonance was used to evaluate the morphological results. The shrinkage of the syrinx, upward migration of the hindbrain, the formation of an artificial cisterna magna were observed. CONCLUSIONS: Craniovertebral decompression and posterior fossa reconstruction in restoring the craniovertebral junction are recommended in the treatment of CM-SM complex.

Adolescent↗

PubMed2000

[CO2 laser-microscopy technique in treating tumors near the sella turcica].

OBJECTIVE: To assess the laser-microscopy technique in dealing with tumors near the sella turcica. METHODS: Sixteen patients with tumors near the sella turcica who had been treated surgically by laser-microscopy technique from October 1996 to June 1998 in Haikou municipal hospital were analyzed retrospectively. RESULTS: In these patients, 11 patients had tumors bodies excised totally, and 5 had tumors bodies excised partially. All of then were followed up for 4 to 30 months. The curative effects were satisfactory. In 9 patients with defect in vision before operation, 6 showed obvious improvement, 2 moderate improvement, and 1 unmarked improvement. In 6 patients with endocrinopathy before operation, 4 returned to normal, and 2 showed improvement. In 4 patients with intracranial hypertension before operation, symptoms were retrieved. Only one patient who had diabetes insipidus after operation, and recovered after medication. CONCLUSIONS: CO(2) laser-microscopy technique the treatment of tumors near the sella turcica is advantageous: few accidental injuries because of its high-accuracy; less harassment to the hypophysis and subthalamus; less complication; small exposure of operative field; less bleeding and clear operative field; no stimulation of metastasis of carcinoma;and no interference of bioelectric current.

Adult↗

PubMed2000

[Surgery for patients with primary liver cancer: report of 1,038 patients].

OBJECTIVE: To investigate methods for enhancing safety of and improving the survival in patients with primary liver cancer (PLC). METHODS: One thousand and thirty eight patients with PLC were treated in our hospital from January 1990 to December 1998. The early period group (from January 1990 to December 1996) consisted of 731 patients [312 patients (42.7%) receiving liver resection]; the late period group (from January 1997 to December 1998) included 307 patients [217 patients (70.7%) receiving liver resection]. RESULTS: The mortality within one month after hepatectomy was 2.24% in the early group and 0.74% in the late group. The 1-, 3- and 5-year survival rates were 73.1%, 54.2%, and 34.0% respectively in patients undergoing hepatectomy in the early group and 91.1%, 63.8% and 40.2% in the late group. CONCLUSIONS: Regular follow-up of high risk patients is helpful to discover small PLC. High proportion of small PLC, progress of perioperative management, and improvement of operative techniques including hepatopetal blood occlusion of half liver or in vitro-bypass through bio-pump during hepatectomy might be important approaches to enhance the safety of surgical treatment and improve the prognosis of patients with PLC.

Adolescent↗

PubMed2000

[Surgical treatment of left main stenosis in coronary artery disease].

OBJECTIVE: To study the efficacy of surgical treatment in the patients with left main stenosis of 50% or more. METHODS: Forty-two patients with left main stenosis (LMS) underwent coronary artery bypass grafting (CABG). Their mean age was 68.7 years. 16 patients had 50% to 75% LMS and 26 patients more than 75%. Twenty-nine patients had unstable angina. Seventeen patients with angina were in class III according to CCSS and 18 were in class IV. Preoperative left ventricular ejection fraction in 24 patients was beyond 50%. RESULTS: The mean preoperative hospital stay was 2.3 days. The mean number of grafts was 3.3 per patient. There was no operative death. The patients were all free from angina postoperatively. The mean follow up time was 42 (3 to approximately 78) months without death. CONCLUSIONS: Coronary artery bypass grafting is the first choice to treat left main stenosis. It is a safe and effective method. To determine properly the time of surgical intervention is helpful to reduce preoperative cardiac affairs and improve operative efficacy.

Aged↗

PubMed2000

[Perioperative changes of plasma ET-1 in patients undergoing coronary artery bypass grafting and the effect of nitroglycerin].

OBJECTIVE: To observe the dynamic changes of the plasma ET-1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery. METHODS: 40 patients with coronary artery bypass surgery were divided into group A and B. Group B received intravenous nitroglycerin 1 microg x kg(-1) x min(-1) perioperatively. We used RIA to assay the plasma ET-1 level. All the hemodynamic parameters were recorded by the Swan-Ganz catheter. RESULTS: The preoperative plasma ET-1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopulmonary bypass in these patients the plasma ET-1 level was increased significantly until 6 to 8 hours after operation. The increased plasma ET-1 level in group B was less than in group A. There was a positive correlation between the plasma ET-1 level and the mean pulmonary pressure in group A 2 and 8 hours after operation. CONCLUSION: In patients undergoing coronary artery bypass surgery, the increased plasma ET-1 level may be partly due to the influence of cardiopulmonary bypass. Low dose of nitroglycerin is beneficial to these patients.

Coronary Artery Bypass↗

PubMed2000

[Telomerase activity and cellular apoptosis of bladder cancers].

OBJECTIVE: To explore the relationship between clinicobiological acting, telomerase activity and cellular apoptosis of bladder cancer. METHODS: The intensity of telomerase activity and cellular apoptosis of bladder cancer were detected by telomeric repeat amplification protocol (TRAP) and terminal deoxynucleotidyl-transferase mediated dUTP-biotin nick end labeling (TUNEL) assay respectively. RESULTS: The positive rate of telomerase activity of bladder cancer was 89.29% and the apoptosis index of bladder cancer was (45.16 +/- 14.43)%. The intensity of telomerase activity and apoptosis index of bladder cancer were not related to patient's age, sex, size or number of tumor (P > 0.05), but to the "grade", "stage" and prognosis of bladder cancer (P < 0.01). The higher the intensity of telomerase activity or less cellular apoptosis, the poor prognosis of differentiated or more advanced bladder cancer. The intensity of telomerase activity was negatively correlated with cellular apoptosis of bladder cancer (r = -0.69, P < 0.01). CONCLUSIONS: The intensity of telomerase activity and cellular apoptosis are correlated with the grade, stage and prognosis of bladder cancer. The detection of telomerase activity and cellular apoptosis are helpful in clinical analysis and evaluation of prognosis of bladder cancer.

Adult↗

PubMed2000

[Unsuccessful operative treatment of acute thoracic and thoracolumbar injuries with neurologic deficit].

OBJECTIVE: To analyze the main factors for unsuccessful operative treatment of acute thoracic and thoracolumbar injuries with neurologic deficit. METHODS: 82 patients with acute thoracic and thoracolumbar injuries with neurologic deficit who had had unsuccessful operations in other hospitals were reviewed. Clinical materials and radiographs including plane and functional films and CT scans were analyzed. RESULTS: In the 82 patients 30 had unsuccessful reduction or spinal deformity, and 31 canal encroachment. In 12 pedicle screws located out of the pedicle, 2 penetrated the canal and 3 pressed against the aorta. 41 patients who complained back pain, 16 had mechanical spinal instability, and 3 neurological instability. CONCLUSION: The main factors for unsuccessful operative management include inappropriate selection of surgical indications and inaccurate use of surgical technique.

Acute Disease↗

PubMed2000

[The modulating effect of panax pseudoginseng wall saponins on the DAG-PKC signal pathway and TNF secretion of macrophages].

OBJECTIVE: To explore the roles of panax pseudoginseng wall saponins on the DAG-PKC signal pathway and TNF secretion of macrophages. METHODS: The changes of the activities of postburn inositol lipid signal system factors such as PLC, DAG, cytomembrane PKC, cytoplasma PKC, and intracellular calcium concentration and the secretory amount of macrophage TNF were observed. RESULTS: Panax pseudoginseng wall saponins could reduce the increased PLC activity from 57.58 +/- 8.19 to 27.00 +/- 2.31 and the intracellular calcium concentration from 393.18 +/- 392.62 to 90.56 +/- 7.21. With the role of panax pseudoginseng wall saponins, DAG activity reduced from 488.10 +/- 40.20 to 288.30 +/- 30.00, cytomembrane PKC activity decreased from 3081.50 +/- 698.50 to 1699.50 +/- 218.50, and cytoplasmic PKC activity from 2 188.60 +/- 258.30 to 848.40 +/- 138.30. The secretory TNF amount of macrophage decreased by 55%. CONCLUSION: Panax pseudoginseng wall saponins might play an very important role in the modulating of the DAG-PKC signal pathway and decreased TNF secretion of macrophage.

Animals↗

PubMed2000

[Reversal of severe left ventricular dilatation after operation and its correlation with cardiac function].

OBJECTIVE: To investigate the relationship between the reversal of left ventricular dilatation and postoperative cardiac function, and prognosis. METHODS: 16 patients with severely dilated left ventricle underwent echocardiographic examinations preoperatively and at discharge (7 - 10 days after operation). Left ventricular (LV) diameters were measured (LVEDD, LVESD) and matched to body surface area (LVEDDI, LVESDI) and fractional shortening (FS); left ventricular ejection fraction (EF) was calculated. RESULTS: Left ventricular dimensions significantly decreased at discharge after operation. Preoperative LVEDD was (78.54 +/- 6.30) mm and postoperative LVEDD (63.77 +/- 13.69) mm (P < 0.01). Preoperative LVESD (60.03 +/- 8.95) mm and postoperative LVESD (53.23 +/- 12.68) mm (P < 0.05). Preoperative LVEDDI was (44.10 +/- 5.24) mm/m(2) and postoperative LVEDDI (36.01 +/- 9.53) mm/m(2) (P < 0.01). Preoperative LVESDI was (34.78 +/- 6.22) mm/m(2) and postoperative LVESDI (30.90 +/- 9.19) mm/m(2) (P < 0.05). Left atrium (LA) dimension was shorter after operation than before operation. Left ventricular construction didn't improve postoperatively, even temporarily decreased at discharge. Preoperative EF was (48.00 +/- 11.71)% and postoperative EF (40.15 +/- 8.69)% (P < 0.01). Preoperative FS was (22.82 +/- 6.27)% and postoperative FS (19.63 +/- 3.42) (P > 0.05). The incidence of postoperative cardiac arrhythmia was 75%. No dimension changes were observed in 2 patients with severely dilated left ventricles after operation: one (LVEDDI 56 mm/m(2)) died, and the other had severe low cardiac output. Six of 14 who had reduced dilated left ventricle didn't reach normal limits, still in the range of severe dilated left ventricule (LVEDDI > 37 mm/m(2)). CONCLUSIONS: Most patients decreased the dimension of left ventricular size early after operation, but some had partial recovery from severe ventricular dilatation. Although left ventricular dimensions (LVEDD, LVESD, LVEDDI, LVESDI) significantly reduced, cardiac function didn't improve at once with the reversal of left ventricular dilatation, but temporarily decreased after operation and the incidence of cardiac arrhythmia was high.

Adult↗

PubMed2000

[An experimental study on F-heparin surface modified IOLs implanted into the Rhesus monkeys' eyes].

OBJECTIVE: To evaluate the biocompatibility of F-heparin surface modified IOLs. METHODS: 13 monkeys were divided into 3 groups, and implanted with different surface modified and non-modified IOLs into their eyes. All of the eyes were examined by slitlamp microscope and Schiötz tonometer at postoperative 15, 30, 60, 90 and 180 days. Postoperatively, at different periods the aqueous was aspirated from the anterior chamber to calculate cells. RESULTS: F-heparin surface modified IOLs induced milder inflammatory reaction and less dense posterior capsula opacification (PCO) than non-modified IOLs. CONCLUSION: F-heparin surface modified IOL has a better biocompatibility.

Animals↗

PubMed2000

[Immunohistochemical findings on liver tissue in patients with hepatitis C].

OBJECTIVE: To investigate the distributions and infer relations of HCV antigens in the liver tissues. METHODS: Immunohistochemical techniques as polyclonal antibody to HCV, monoclonal antibody to HCV - NS3 and monoclonal antibody to HCV - NS5 were used to detect HCV antigens in 107 patients with hepatitis C. RESULTS: HCV antigens in liver tissues were identified on these three kinds of antibodies. The positive rates were 38.3%, 28.0% and 52.3% respectively. The positive granules were located in the cytoplasma of liver cells. The distributions of positive cells were scattered, diffusive and clustered. No obvious anatomic association was observed between the expression of HCV - NS3 and inflammatory reaction. HCV - NS5 positive cells were more commonly seen around or in the flammatory focci. CONCLUSION: The expressions of various components of HCV were demonstrated in different concentrations. The expressions of HCV - NS5 might be related to the pathogenesis of hepatitis C.

Adult↗