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Biomedical subjects

X B Huang

Publications and source records attributed to X B Huang.

11 recordsLinked to original sources
PubMed1996

Antenatal assessment using the FECG obtained via abdominal electrodes.

During the past decade a variety of intrapartum fetal monitors have been constructed that process the entire fetal electrocardiogram (FECG), obtained via a scalp electrode. They therefore differ from conventional monitors in aiming to extract relevant timing and magnitude information from the morphology of the FECG rather than simply the RR interval and hence heart rate. An intrapartum monitor such as this has been successfully developed by ourselves. This paper describes the early results obtained whilst attempting to extend this form of monitoring forward into the antenatal period. In order to achieve this the FECG must be acquired via surface electrodes placed on the maternal abdomen, which yields a signal containing the FECG amidst a number of noise sources. Our investigations into the feasibility of "antenatal abdominal FECG analysis" have been on two fronts. The first has been to produce a bedside monitor similar in function to our intrapartum device, whilst the second has been to address the possibility of performing such monitoring in ambulant subjects. At present the antenatal bedside monitor has successfully extracted and processed the FECG in approximately 75% of the cases studied, with subjects ranging from 20 weeks through to term having been monitored. We also have demonstrated the feasibility of the long term monitoring of maternal and fetal heart rate using a portable instrument.

Abdomen↗
PubMed1995

Sequential recording of the abdominal fetal electrocardiogram and magnetocardiogram.

The aim of this study was to demonstrate the acquisition of both the fetal magnetocardiogram (FMCG) and fetal electrocardiogram (FECG) from the abdomen of the same subject. This contrasts with previous reported studies which have generally recorded one or other of these signals but not the two together. Both signals were successfully recorded and averaged to produce a typical complex, thus allowing their direct comparison.

Electrocardiography↗
PubMed1994

A windows application for real-time fetal ECG analysis.

Analysis of the fetal electrocardiogram (FECG) from abdominal recordings may be used as a noninvasive technique to assess fetal well being. Consequently, interest has arisen in the development of a real-time fetal ECG monitoring system. In this paper, we present a Windows user interface developed for our antenatal FECG analysis system. The program (FECGV1), written in C++, consists of three principal modules: System Setup, Real-Time FECG Analysis, and Result Review. By adopting the Windows' graphical user interface and object-oriented programming methodology, the system software accomplished the goals of visualization, easy use, extensibility, and user adaptability. Preliminary clinical application has shown that this approach provides a strong basis for a solution to real-time antenatal FECG analysis.

Computer Graphics↗
PubMed1994

[Role of several hosts in transmission of Schistosomiasis japonica in lake region].

From 1989 to 1990, an investigation was conducted in three villages in Junsan township, Hanyang County, Hubei Province. The results showed that the infection rates of local residents were 55.1%, 49.5% and 44.3%, respectively; the EPG were 5.6, 5.2 and 2.0, respectively; the relative transmission index (RTI) were 7.1%, being highest in the age group 30-39 years. The relative index of potential contamination (IPC) was 67.2% in the age group 20-49 years, this group was considered as the main transmission source in the population. In animal hosts buffaloes, pigs and dogs, the infection rates were 35.7%, 60.0% and 75.0%, respectively; MPG (miracidium per gram), 0.4, 0.4 and 80.4, respectively; RTI (relative transmission index), 38.6%, 7.7 and 46.6%, respectively. The infection rates of pigs and dogs were high in Huangshi village, while the infection rate of buffaloes was high in Chuangjiang village. These results coincided with the transmission of schistosomiasis in these villages. The results showed that dogs as the main transmission sources had important significance in the epidemiology of schistosomiasis and that buffaloes and pigs herd and fed in the snail-habitats could be heavily infected.

Adolescent↗
PubMed1992

Fast ECG data compression algorithms suitable for microprocessor systems.

ECG data compression techniques have received extensive attention in ECG analysis. Numerous data compression algorithms for ECG signals have been proposed during the last three decades. We describe two algorithms based on the scan-along polygonal approximation algorithm (SAPA) that are suitable for multichannel ECG data reduction on a microprocessor-based system. One represents a modification of SAPA (MSAPA) which adopts the method of integer division table searching to speed up data reduction; the other (CSAPA) combines MSAPA and TP, a turning-point algorithm, to preserve ST segment signals. Results show that our algorithms achieve a compression ratio of more than 5:1 and a percent rms difference (PRD) to the original signal of less than 3.5%. In addition, the maximum execution time of MSAPA for processing one data point is about 50 microseconds. Moreover, the CSAPA algorithm retains all of the details of the ST segment, which are important in ischaemia diagnosis, by employing the TP algorithm.

Algorithms↗
PubMed1989

Clinical significance of urine ferritin determination in urologic malignancies.

Urine and serum ferritin levels were measured by a double-antibody radio-immunoassay in 96 normal adults and 57 patients with urologic malignancies. In the 96 adults, the urine ferritin levels ranged from 0 to 28 ng/ml. Elevated urine ferritin levels were observed in all 7 patients with renal pelvic carcinoma, 4 of 13 patients with renal carcinoma, 1 of 13 patients with well-differentiated (Grade I) bladder carcinoma, 8 of 19 patients with median-differentiated (Grade II) bladder carcinoma, and all 5 patients with poorly-differentiated (Grades III, IV) bladder carcinoma. These results indicated that urine ferritin assay was helpful in discriminating well-differentiated bladder carcinoma from the poorly-differentiated (P less than 0.01) in addition to differentiating renal pelvic carcinoma from renal carcinoma (P less than 0.05).

Adolescent↗
PubMed1986

[Tumor of the penis--analysis of 300 cases].

300 cases of penile tumor are reported. The age peak was over 41 years (79.0%). Of these 300 cases, (66.7%) had redundant prepuce and 78 (26.0%) had phimosis which implies that penile tumors are closely related to those two conditions. Surgical treatment consisted of partial resection of penis in 182 (60.7%) patients, total resection in 66 (22.0%) and ilioinguinal lymphadenectomy after resection in 29 (9.7%). The pathological findings showed that in majority of cases, it was squamous cell carcinoma (270, 90.0%). Only 90 (30.0%) patients survived among the followed up patients. 20 patients have survived over 20 years and 32 over 15 years. It seems that the long term result of penile tumors after operation is better than that of other uro-genital neoplasms. Stricture of external meatus occurred in 22 patients and all were promptly relieved by dilation.

Adult↗
PubMedDate not supplied

Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats.

Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a Chinese herb Erigeron breviscapus (Vant.) Hand.-Mazz. The pharmacokinetics of scutellarin and its aglycone conjugated metabolites after intraperitoneal injection and oral administration of breviscapine was investigated in rats. The plasma concentration of scutellarin and scutellarein conjugates in serial samples was measured by validated high-performance liquid chromatography methods. The pharmacokinetic results indicated that scutellarin underwent rapid and extensive biotransformation in vivo. After intraperitoneal injection, scutellarin was absorbed rapidly. The profiles of scutellarin and scutellarein conjugates were fitted to a two-compartment open model. Scutellarin and scutellarein conjugates showed a similar time course. No significant difference in tmax, t0.5(alpha) and t0.5(beta) was observed between scutellarin and scutellarein conjugates (p>0.05). After oral administration, fluctuations were observed in the concentration-time profiles of both scutellarin and scutellarein conjugates and the pharmacokinetics could not be explained by classical compartment model. The relative bioavailability of oral administration was very low, 10.67 % +/- 4.78% for scutellarin and 7.92% +/- 1.90% for scutellarein conjugates.

Animals↗