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Chemistry, Clinical↗
Biomedical subjects
Wojciech Gernand
Publications and source records attributed to Wojciech Gernand.
[Analysis of early surgical complications after strumectomy].
UNLABELLED: The aim of the study was the analysis of early surgical complications after strumectomy. MATERIAL AND METHODS: The study involved 578 patients operated on in I Clinic of General Surgery and Transplant at the Medical Academy in Lublin in the years 1999-2002. The largest group of the operated patients was the one with a non-toxic (neutral) goitre (60.1%). Most of the patients in this group had multinodular neutral goitre. The amount of the surgically treated patients because of the hyperactive goitre prevailed in this group. RESULTS: Early postoperative complications were observe d in 35 cases, which comprise 6.05% of the operated patients. On the basis of the obtained results, we stated that there are evident differences in the frequency of occurrence of early complications depending on the type of the goitre. We concluded that statistically they were more frequent in patients operated on because of Graves-Basedov disease as well as in patients with Hashimoto goitre (chi2 test p < 0.001). The amount of the strumectomy operations conducted annually by a surgeon did not have direct influence on the occurrence of the early complications. CONCLUSIONS: Early postoperative complications after strumectomy are more frequent in patients operated on because of diseases of autoimmunological basis. Operations of the thyroid gland and trainings in the surgery of the thyroid gland should take place in centers where large amount of such operations are conducted.
Adult↗
Estimation of CA 125 concentration in patients with congestive heart failure.
Tumour marker CA 125 is used in the monitoring results of treatment woman with ovarian cancer. Its diagnostic effectiveness in selected groups of patients is defined by sensitivity estimated at approximately 75% and specifity at 95%. In practice diagnostic specificity of CA 125 concentration is lower as it is limited by the increase of concentration different tumour diseases (bladder cancer) and non-tumour diseases (pericardial inflammation). The aim of the paper was to estimate CA 125 concentration in patients with congestive heart failure as well as to define the range of changes taking place according to the advancement of the disease. The research included 39 patients: 20 women and 19 men aged 45-75 with diagnosed congestive heart failure graded II-IV in the NYHA classification. It has been found that CA 125 concentration in blood serum of the patiens with congestive heart failure was on average approximately 35.4 +/- 24.8 U/ml and was included in the range from 5.6 to 874 U/ml (limit value 21 U/ml). The concentration increase above the limit value was observed in 34% of patients. Significant statistic differences in CA 125 concentration rates were dependent on the disease advancement. The highest concentration rates were observed in patients classified in group IV NYHA. The results that have been obtained allow us to draw a conclusion that right interpretation of CA 125 concentration in clinical practice (screening examinations, establishment of the level of advancement, prognostication as well as monitoring the ovarian cancer treatment) brings the necessity of taking into consideration the degree of congestive heart failure.
Aged↗
Perception of emotions from faces and voices following unilateral brain damage.
The importance of the right hemisphere in emotion perception in general has been well documented but its precise role is disputed. We compared the performance of 30 right hemisphere damaged (RHD) patients, 30 left hemisphere damaged (LHD) patients, and 50 healthy controls on both facial and vocal affect perception tasks of specific emotions. Brain damaged subjects had a single episode cerebrovascular accident localised to one hemisphere. The results showed that right hemisphere patients were markedly impaired relative to left hemisphere and healthy controls on test performance: labelling and recognition of facial expressions and recognition of emotions conveyed by prosody. This pertained at the level of individual basic emotions, positive versus negative, and emotional expressions in general. The impairment remained highly significant despite covarying for the group's poorer accuracy on a neutral facial perception test and identification of neutral vocal expressions. The LHD group were only impaired relative to controls on facial emotion tasks when their performance was summed over all the emotion categories and before age and other cognitive factors were taken into account. However, on the prosody test the LHD patients showed significant impairment, performing mid-way between the right hemisphere patients and healthy comparison group. Recognition of positive emotional expressions was better than negative in all subjects, and was not relatively poorer in the LHD patients. Recognition of individual emotions in one modality correlated weakly with recognition in another, in all three groups. These data confirm the primacy of the right hemisphere in processing all emotional expressions across modalities--both positive and negative--but suggest that left hemisphere emotion processing is modality specific. It is possible that the left hemisphere has a particular role in the perception of emotion conveyed through meaningful speech.
Adult↗